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Effects of dietary iron deficiency and tungsten supplementation on 59Fe absorption and gastricretention from 59Fe compounds in rats

Published online by Cambridge University Press:  09 March 2007

Gillian E. Shears ,
R. J. Neale  and
D. A. Ledward
Gillian E. Shears
Affiliation:
Department of Applied Biochemistry and Food Science, Nottingham University, School of Agriculture, Sutton Bonington, Loughborough LE12 5RD, Leics.
R. J. Neale
Affiliation:
Department of Applied Biochemistry and Food Science, Nottingham University, School of Agriculture, Sutton Bonington, Loughborough LE12 5RD, Leics.
D. A. Ledward
Affiliation:
Department of Applied Biochemistry and Food Science, Nottingham University, School of Agriculture, Sutton Bonington, Loughborough LE12 5RD, Leics.
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Abstract

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1. In vivo 59Fe absorption from intrinsically labelled Fe-containing fractions of liver and blood were measured in rats by intragastric dosing. All rats were fed on a low-Fe diet for 3 d before dosing in order to standardize the Fe status of the intestinal mucosal cells.

2. An increase in digestion time from 2 to 12 h increased 59Fe absorption (P < 0.01) from all fractions except ferritin.

3. Fe-deficient rats when compared with essentially Fe-replete rats showed decreased gastric retention for all fractions, but increased 59Fe absorption over 2 h only from ferritin. Ferritin showed several unusual absorption characteristics.

4. Dietary tungsten supplementation of Fe-deficient rats reduced the ferroxidase activity of intestinal mucosal xanthine oxidase. In addition, gastric retention and 59Fe absorption (P < 0.05) from all fractions were increased.

Type
Minerals
Information
British Journal of Nutrition , Volume 61 , Issue 3 , May 1989 , pp. 573 - 581
Copyright
Copyright © The Nutrition Society 1989

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