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Effects of dietary polychlorinated biphenyls on cholesterol catabolism in rats

Published online by Cambridge University Press:  09 March 2007

Satoshi Nagaoka ,
Hitoshi Miyazaki ,
Yoritaka Aoyama  and
Akira Yoshida
Satoshi Nagaoka
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Hitoshi Miyazaki
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Yoritaka Aoyama
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Akira Yoshida
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
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Abstract

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Dietary polychlorinated biphenyls (PCBs) caused hypercholesterolaemia in rats. The concentration and output of biliary cholesterol was significantly lower than that of the control group. Biliary output of total bile acids was significantly decreased in rats given the PCB-supplemented diet. Faecal excretion of total steroids (sum of neutral steroids and acidic steroids) was not significantly changed in rats given the PCB-supplemented diet. The present results indicate that dietary PCBs cause hypercholesterolaemia without modifying the faecal total steroids excretion. These results suggest that PCBs produce hyper-cholesterolaemia accompanied by changes in biliary or faecal excretion of bile acids and neutral steroids in addition to an increase in hepatic cholesterol synthesis.

Keywords

Bile acidsCholesterolPolychlorinated biphenylsRat
Type
Cholesterol Metabolism
Information
British Journal of Nutrition , Volume 64 , Issue 1 , July 1990 , pp. 161 - 169
Copyright
Copyright © The Nutrition Society 1990

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