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Effects of exogenous glucose on glucose metabolism in the lactating goat in vivo

Published online by Cambridge University Press:  09 March 2007

N. Chaiyabutr ,
Anne Faulkner  and
M. Peaker
N. Chaiyabutr
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, Scotland
Anne Faulkner
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, Scotland
M. Peaker
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, Scotland
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Abstract

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1. Glucose turnover in fed and 48 h-starved lactating goats was determined during a glucose load of 500 μmol/min using a continuous infusion of [U-14C]- and [3-3H]glucose.

2. Endogenous rates of irreversible glucose turnover (i.e. total rates of irreversible glucose turnover minus the rate of exogenous glucose supply) were depressed during glucose loading by 14 and 62% in the fed and starved animals respectively.

3. Plasma glucose concentrations increased significantly by 57 and 88% in the fed and starved goats respectively. Plasma insulin concentrations increased by 108 and 128% in the fed and starved animals respectively.

4. Milk yields increased significantly (41%) in the starved animals during glucose loading, but were unaffected in fed animals.

5. In both the fed and 48 h-starved goats, mammary glucose metabolism via glycolysis and the pentose phosphate pathway appeared to be stimulated by glucose loading.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 1 , January 1983 , pp. 159 - 165
Copyright
Copyright © The Nutrition Society 1983

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