Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-11T07:41:41.640Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers

Published online by Cambridge University Press:  08 March 2007

A. Gostner ,
V. Schäffer ,
S. Theis ,
T. Menzel ,
H. Lührs ,
R. Melcher ,
J. Schauber ,
T. Kudlich ,
G. Dusel  and
D. Dorbath
...Show all authors
A. Gostner*
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
V. Schäffer
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
S. Theis
Affiliation:
SUEDZUCKER AG, Wormser Strasse 11, D-67283 Obrigheim/Pfalz, Germany
T. Menzel
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
H. Lührs
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
R. Melcher
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
J. Schauber
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
T. Kudlich
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
G. Dusel
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
D. Dorbath
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
G. Kozianowski
Affiliation:
SUEDZUCKER AG, Wormser Strasse 11, D-67283 Obrigheim/Pfalz, Germany
W. Scheppach
Affiliation:
Department of Medicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany
*
*Corresponding author: Dr Andrea Gostner, fax +49 931 201 36 101, email gostner_a@klinik.uni-wuerzburg.de
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The polyol isomalt (Palatinit®) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined in a randomised, double-blind, cross-over trial with two 4-week test periods. Volunteers received 30 g isomalt or 30 g sucrose daily as part of a controlled diet. In addition to clinical standard diagnostics, biomarkers and parameters currently discussed as risk factors for CHD, diabetes or obesity were analysed. Urine and stool Ca and phosphate excretions were measured. In addition, mean transit time, defecation frequency, stool consistency and weight were determined. Consumption of test products was affirmed by the urinary excretion of mannitol. Blood lipids were comparable in both phases, especially in volunteers with hyperlipidaemia, apart from lower apo A-1 (P=0·03) for all subjects. Remnant-like particles, oxidised LDL, NEFA, fructosamine and leptin were comparable and not influenced by isomalt. Ca and phosphate homeostasis was not affected. Stool frequency was moderately increased in the isomalt phase (P=0·006) without changes in stool consistency and stool water. This suggests that isomalt is well tolerated and that consumption of isomalt does not impair metabolic function or induce hypercalciuria. In addition, the study data indicate that isomalt could be useful in improving bowel function.

Keywords

IsomaltMetabolic parametersStool parametersHealthy volunteers
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 4 , October 2005 , pp. 575 - 581
Copyright
Copyright © The Nutrition Society 2005

References

Alles, MS, Hautvast, JG, Nagengast, FM, Hartemink, R, Van Laere, KMJ & Jansen, JBMJ (1996) Fate of fructo-oligosaccharides in the human intestine. Br J Nutr 76, 211–221.CrossRefGoogle ScholarPubMed
Alles, MS, de Roos, NM, Bakx, JC, Van de Lisdonk, E, Zock, PL & Hautvast, GA (1999) Consumption of fructooligosacchrides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. Am J Clin Nutr 9, 64–69.CrossRefGoogle Scholar
Bär, A (1990) Factorial calculation model for the estimation of the physiological caloric value of polyols. In Proceedings of the International Symposium on Caloric Evaluation of Carbohydrates, 209–257 [Hosoxa, N, editor]. Tokyo: Research Foundation for Sugar Metabolism.Google Scholar
Brighenti, F, Casiraghi, MC, Canzi, E & Ferrari, A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy young male volunteers. Eur J Clin Nutr 53, 726–733.CrossRefGoogle Scholar
Burkitt, DP, Walker, ARP & Painter, NS (1972) Effect of dietary fibre on stools and transit times, and its role in the causation of disease. Lancet 2, 1408–1411.CrossRefGoogle ScholarPubMed
Burkitt, DP, Walker, AR & Painter, NS (1974) Dietary fiber and disease. JAMA 229, 1068–1074.CrossRefGoogle ScholarPubMed
Chen, HL, Lu, YH, Lin, JJ & Ko, LY (2001) Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men. J Am Coll Nutr 20, 44–49.CrossRefGoogle ScholarPubMed
Cummings, JH & Wiggins, HS (1976) Transit through the gut measured by analysis of a single stool. Gut 17, 219–223.CrossRefGoogle ScholarPubMed
Cummings, JH, Branch, WJ, Jenkins, DJA, Southgate, DAT, Houston, H & James, WPT (1978) Colonic response to dietary fibre from carrot, cabbage, apple, bran, and guar gum. Lancet 1, 5–9.CrossRefGoogle Scholar
Cummings, JH, Bingham, SA, Heaton, KW & Eastwood, MA (1992) Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology 103, 1783–1789.CrossRefGoogle ScholarPubMed
Dills, WL (1989) Sugar alcohols as bulk sweeteners. Annu Rev Nutr 9, 161–186.CrossRefGoogle ScholarPubMed
Gee, JM, Cooke, D, Gorick, S, Wortley, GM, Greenwood, RH, Zumbe, A & Johnson, IT (1991) Effects of conventional sucrose-based, fructose-based and isomalt-based chocolates on postprandial metabolism in non-insulin-dependent diabetics. Eur J Clin Nutr 45, 561–566.Google ScholarPubMed
Gehring, F & Karle, EJ (1981) [Sweetening agent, Palatinit under specific consideration as to microbiological and caries-prophylactic aspects]. Z Ernahrungswiss 20, 96–106.CrossRefGoogle ScholarPubMed
Hillman, L, Peters, S, Fisher, A & Pomare, EW (1983) Differing effects of pectin, cellulose and lignin on stool pH, transit time and weight. Br J Nutr 50, 189–195.CrossRefGoogle ScholarPubMed
Hütter, R, Böswart, F & Irsigler, K (1993) [Insulinverbrauch von Typ-I-Diabetikern nach oraler Gabe von Isomalt]. Akt Ernähr 18, 149–154.Google Scholar
Hylla, S, Gostner, A, Dusel, G, Anger, H, Bartram, HP, Christl, SU, Kasper, H & Scheppach, W (1998) Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention. Am J Clin Nutr 67, 136–142.CrossRefGoogle Scholar
Koutsou, GA, Storey, DM, Lee, A, Zumbe, A, Flourie, B, leBot, Y & Olivier, P (1996) Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate. Eur J Clin Nutr 50, 17–21.Google ScholarPubMed
Laker, MF, Bull, HJ & Menzies, IS (1982) Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur J Clin Invest 12, 485–491.CrossRefGoogle ScholarPubMed
Lee, A, Wils, D, Zumbe, A & Storey, DM (2002) The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC. Eur J Clin Nutr 56, 755–764.CrossRefGoogle ScholarPubMed
Life Science Research Office (1994) The Evaluation of the Energy of Certain Sugar Alcohols used as Food Ingredients. Bethesda, MD: Life Science Research Office, Federation of the American Society for Experimental Biology.Google Scholar
Livesey, G (2001) Tolerance of low-digestible carbohydrates: a general view. Br J Nutr 85, S7–S16.CrossRefGoogle ScholarPubMed
Livesey, G (2003) Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev 16, 163–191.CrossRefGoogle ScholarPubMed
Livesey, G, Buss, D, Coussement, P, Edwards, DG, Howlett, J, Jonas, DA, Kleiner, JE, Müller, D & Sentko, A (2000) Suitability of traditional energy values for novel foods and food ingredients. Food Control 11, 249–289.CrossRefGoogle Scholar
Marteau, P & Flourie, B (2001) Tolerance to low-digestible carbohydrates: symptomatology and methods. Br J Nutr 85, Suppl. 1, S17–S21.CrossRefGoogle ScholarPubMed
Petzoldt, R, Lauer, P, Spengler, M & Schoffling, K (1982) [Palatinite in type II diabetics. Effect on blood-glucose, serum-insulin, C-peptide and free fatty acids]. Dtsch Med Wochenschr 107, 1910–1913.CrossRefGoogle ScholarPubMed
Rendtorff, RC & Kashgarian, M (1967) Stool patterns of heathy adult males. Dis Colon Rectum 10, 222–228.CrossRefGoogle Scholar
Scheppach, W, Fabian, C, Ahrens, F, Spengler, M & Kasper, H (1988) Effect of starch malabsorption on colonic function and metabolism in humans. Gastroenterology 95, 1549–1555.CrossRefGoogle ScholarPubMed
Scheppach, W, Luehrs, H & Menzel, T (2001) Beneficial health effects of low-digestible carbohydrate consumption. Br J Nutr 85, Suppl. 1, S23–S30.CrossRefGoogle ScholarPubMed
Scholz, GH, Englaro, P, Thiele, I, Scholz, M, Klusmann, T, Kellner, K, Rascher, W & Blum, WF (1996) Dissociation of serum leptin concentration and body fat content during long term dietary intervention in obese individuals. Horm Metab Res 28, 718–723.CrossRefGoogle ScholarPubMed
Schreuder, PCNJ, Twickler, TB, Wang, T, Nakajima, K, Erkelens, DW & Dallinga-Thie, GM (2001) Isolation of remnant particles by immunoseparation: a new approach for investigation of postprandial lipoprotein metabolism in normolipidemic subjects. Atherosclerosis 157, 145–150.CrossRefGoogle ScholarPubMed
Spiller, GA, Chernof, MC, Hill, RA, Gates, JE, Nassar, JJ & Shipley, EA (1980) Effect of purified cellulose, pectin, and a low-residue diet on fecal volatile fatty acids, transit time, and fecal weight in humans. Am J Clin Nutr 33, 754–759.CrossRefGoogle Scholar
Storey, DM, Lee, A & Zumbe, A (2002) The comparative gastrointestinal response of young children to the ingestion of 25 g sweets containing sucrose or isomalt. Br J Nutr 87, 291–297.CrossRefGoogle ScholarPubMed
Zumbe, A & Brinkworth, RA (1992) Comparative studies of gastrointestinal tolerance and acceptability of milk chocolate containing either sucrose, isomalt or sorbitol in healthy consumers and type II diabetics. Z Ernahrungswiss 31, 40–48.CrossRefGoogle ScholarPubMed