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Effects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (fa/fa) Zucker rats

Published online by Cambridge University Press:  09 March 2007

G. Flo ,
S. Vermaut ,
V. M. Darras ,
M. Van Boven ,
E. Decuypere ,
R. Kühn ,
P. Daenens  and
M. Cokelaere
G. Flo
Affiliation:
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium
S. Vermaut
Affiliation:
Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium
V. M. Darras
Affiliation:
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium
M. Van Boven
Affiliation:
Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium
E. Decuypere
Affiliation:
Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium
R. Kühn
Affiliation:
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium
P. Daenens
Affiliation:
Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium
M. Cokelaere*
Affiliation:
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium
*
*Corresponding author: Professor M. Cokelaere, fax +32 56 246997, email Marnix.Cokelaere@kulak.ac.be
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Abstract

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Incorporation of 2·5 g/kg of the anorexigen, simmondsin, in the diet resulted in food intake reduction in both lean and obese Zucker rats; however, the obese rats were much more sensitive to the food intake-reducing activity of simmondsin. In both obese and lean simmondsin-treated Zucker rats, growth was slower than in control rats, but was the same as that in pair-fed animals. The 24 h heat production pattern showed a smaller diurnal variation and a lower mean in obese rats than in lean rats. Food intake reduction, as a result of either simmondsin treatment or pair feeding, caused a decrease in mean heat production. Simmondsin treatment, but not pair feeding, caused a decrease in the diurnal variation of heat production. Plasma total cholesterol levels were increased in both simmondsin-treated and pair-fed obese and lean Zucker rats compared with control animals; this increase was mainly due to an increase in HDL-cholesterol levels. Blood leptin levels in both obese and lean rats decreased with decreased food intake and decreased fat deposition, but in obese rats, simmondsin treatment resulted in an additional decrease in leptin levels. It is concluded that the food intake-reducing effect of simmondsin is more pronounced in obese Zucker rats than in their lean littermates, and except for the simmondsin-specific effects on leptin and total cholesterol values in obese littermates, the effects of simmondsin are related to food intake restriction in obese and lean Zucker rats.

Keywords

SimmondsinFood intakeHeat production
Type
Research Article
Information
British Journal of Nutrition , Volume 81 , Issue 2 , February 1999 , pp. 159 - 167
Copyright
Copyright © The Nutrition Society 1999

References

Alingh Prins, A, de Jong-Nagelsmit, A, Keijser, J & Strubbe, JH (1986) Daily rhythms of feeding in the genetically obese and lean Zucker rats. Physiology and Behavior 38, 423–426.CrossRefGoogle ScholarPubMed
Bach, A, Schirardin, H, Bayer, M & Schaeffer, A (1981) Age related changes in biological parameters in Zucker rats. Lipids 16, 841–848.CrossRefGoogle ScholarPubMed
Barrachina, MD, Martinez, V, Wang, L, Wei, JY & Tache, Y (1997) Synergistic interaction between leptin and cholecystokinin to reduce short term food intake in lean mice. Proceedings of the National Academy of Sciences USA 94, 10455–10460.CrossRefGoogle ScholarPubMed
Booth, A, Elliger, C & Waiss, A Jr (1974) Isolation of a toxic factor in jojoba meal. Life Science 15, 1115–1120.CrossRefGoogle ScholarPubMed
Buyse, J, Decuypere, E, Berghman, L, Kühn, E & Vandezande, F (1992) Effect of dietary protein content on episodic growth hormone secretion and on heat production of male broiler chickens. British Poultry Science 33, 1101–1109.CrossRefGoogle ScholarPubMed
Chua, SC, White, DW, Wu-Peng, S, Liu, S-M, Okada, N, Kershaw, EE, Chung, WK, Power-Kehoe, L, Chua, M, Tartaglia, LA & Leibel, RL (1996) Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45, 1141–1143.CrossRefGoogle ScholarPubMed
Cokelaere, M, Busselen, P, Flo, G, Daenens, P, Decuypere, E, Kühn, E & Van Boven, M (1995 a) Devazepide reverses the anorexic effect of simmondsin in the rat. Journal of Endocrinology 147, 473–477.CrossRefGoogle ScholarPubMed
Cokelaere, M, Dangreau, H, Daenens, P, Bruneel, N, Arnouts, S, Decuypere, E & Kühn, E (1992) Investigation of possible toxicological influences of simmondsin after subacute administration in rats. Journal of Agricultural and Food Chemistry 40, 2443–2445.CrossRefGoogle Scholar
Cokelaere, M, Flo, G, Daenens, P, Decuypere, E, Van Boven, M & Vermaut, S (1996) Food intake inhibitory activity of simmondsin and defatted jojoba meal: dose response curves in rats. In Progress in New Crops, pp. 377–382 [Janick, J, editor]. Alexandria, VA: ASHS Press.Google Scholar
Cokelaere, M, Flo, G, Decuypere, E, Vermaut, S, Daenens, P & Van Boven, M (1995 b) Evidences for a satiating effect of defatted jojoba meal. Industrial Crops and Products 4, 91–96.CrossRefGoogle Scholar
Elliger, C, Waiss, A Jr & Lundin, R (1973) Simmondsin an unusual 2-cyano-ethylenecyclohexyl glucoside from Simmondsia californica. Journal of the Chemical Society Perkin Transactions 19, 2209–2212.CrossRefGoogle Scholar
Flo, G, Daenens, P, Van Boven, M, Vermaut, S, Decuypere, E & Cokelaere, M (1997) Absorption and excretion of simmondsin after different administration routes in rats. Journal of Agricultural and Food Chemistry 45, 185–188.CrossRefGoogle Scholar
Flo, G, Vermaut, S, Van Boven, M, Daenens, P, Buyse, J, Decuypere, E, Kühn, E & Cokelaere, M (1998) Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food intake restricted rats. Hormone and Metabolic Research 30, 504–509.CrossRefGoogle ScholarPubMed
Fukagawa, K, Sakata, T, Yoshimatsu, H, Fujimoto, K & Shiraishi, T (1988) Disruption of light–dark cycle of feeding and drinking behaviour, and ambulatory activity induced by development of obesity in the Zucker rat. International Journal of Obesity 12, 481–490.Google ScholarPubMed
Halberg, F, Johnson, EA, Nelson, W, Runge, W & Sothern, P (1972) Autorhythmometry procedures for physiologic selfmeasurements and their analysis. Physiology Teacher 1, 1–11.Google Scholar
Hardy, LA, Rayner, VD, Holmes, S & Trayhurn, P (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not obese Zucker ( fa/fa) rats as measured by ELISA. Biochemical and Biophysical Research Communications 223, 660–665.CrossRefGoogle Scholar
Joyner, K, Smith, GP & Gibbs, J (1993) Abdominal vagotomy decreases the satiating potency of CCK-8 in sham and real feeding. American Journal of Physiology 264, R912–R916.Google ScholarPubMed
Lanza-Jacobi, S, Stevenson, N & Kaplan, M (1986) Circadian changes in serum and liver metabolites and liver lipogenic enzymes in ad libitum fed lean and obese Zucker rats. Journal of Nutrition 116, 1798–1809.CrossRefGoogle Scholar
McLaughlin, CL & Baile, CA (1980) Decreased sensitivity of Zucker obese rats to the putative satiety agent cholecystokinin. Physiology and Behavior 25, 543–548.CrossRefGoogle Scholar
McLaughlin, CL, Peikin, SR & Baile, CA (1982) Decreased pancreatic exocrine response to cholecystokinin in Zucker obese rats. American Journal of Physiology 242, G612–G619.Google ScholarPubMed
McLaughlin, CL, Peikin, SR & Baile, CA (1983 a) Food intake response to modulation of secretion of cholecystokinin in Zucker rats. American Journal of Physiology 244, R676–R685.Google ScholarPubMed
McLaughlin, CL, Peikin, SR & Baile, CA (1983 b) Trypsin inhibitor effects on food intake and weight gain in Zucker rats. Physiology and Behavior 31, 487–491.CrossRefGoogle ScholarPubMed
Maffei, M, Halaas, J, Ravussin, E, Pratley, RE, Lee, GH, Zhang, Y, Fei, H, Kim, S, Lallone, R, Ranganathan, S, Kern, PA & Friedman, JM (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight reduced subjects. Nature Medicine 1, 1155–1161.CrossRefGoogle Scholar
Matson, CA, Wiater, MF, Kuijper, JL & Weigle, DS (1997) Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 18, 1275–1278.CrossRefGoogle ScholarPubMed
Murakami, DM, Horwitz, BA & Fuller, CA (1995) Circadian rhythms of temperature and activity in obese and lean Zucker rats. American Journal of Physiology 269, R1038–R1043.Google ScholarPubMed
Murakami, T, Yamashita, T, Iida, M, Kuwajima, M & Shima, K (1997) A short form of leptin receptor performs signal transduction. Biochemical and Biophysical Research Communications 231, 26–29.CrossRefGoogle Scholar
Takaya, K, Ogawa, Y, Isse, N, Okazaki, T, Satoh, N, Masuzaki, H, Mori, K, Tamura, N, Hosoda, K & Nakao, K (1996) Molecular cloning of rat leptin receptor isoform complementary DNAs. Identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochemical and Biophysical Research Communications 225, 75–83.CrossRefGoogle ScholarPubMed
Van Boven, M, Blaton, N, Cokelaere, M & Daenens, P (1993) Isolation, purification and stereochemistry of simmondsin. Journal of Agricultural and Food Chemistry 41, 1605–1607.CrossRefGoogle Scholar
Wang, YH, Tache, Y, Sheibel, AB, Go, VL & Wei, JY (1997) Two types of leptin responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. American Journal of Physiology 273, R833–R837.Google Scholar
Westerterp, KR (1994) Energy expenditure. In Food Intake and Energy Expenditure, pp. 235–257 [Westerterp-Plantenga, MS, Fredrix, EWHM, Steffens, AB and Kissileff, HR, editors] Open University of The Netherlands: CRC Press.Google Scholar