Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-13T05:19:52.851Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of various soya protein hydrolysates on lipid profile, blood pressure and renal function in five-sixths nephrectomized rats

Published online by Cambridge University Press:  19 February 2008

Shu-Tzu Chen ,
Hsin-Yi Yang ,
Hui-Yu Huang ,
Sheng-Jeng Peng  and
Jiun-Rong Chen
Shu-Tzu Chen
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Hsin-Yi Yang
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Hui-Yu Huang
Affiliation:
Graduate Institute of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 104, Taiwan
Sheng-Jeng Peng
Affiliation:
Division of Nephrology, Cathay General Hospital, Taipei 106, Taiwan
Jiun-Rong Chen*
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
*
*Corresponding author: Dr Jiun-Rong Chen, fax +886 2 2737 3112, email syunei@tmu.edu.tw
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Studies have demonstrated that isolated soya protein (ISP) can slow the progression of renal injury, reduce blood pressure and improve the serum lipid profile in experimental animals and human subjects. The mechanisms and components of soya responsible have not been fully established. The present study was designed to evaluate the effects of the hydrophilic supernatant fraction (SF) and the hydrophobic precipitate fraction (PF) isolated from soya protein hydrolysate on renal function, lipid metabolism and blood pressure in five-sixths nephrectomized rats. Experimental animals were subjected to a nephrectomy and allocated to four groups (180g casei/g, 180g IS/g, 100g casei/g with 80g S/g, and 100g casei/g with 80g P/g). The SF group had the most significant decreases in blood pressure and total cholesterol, as well as a significantly retarded progression of the experimentally induced renal disease, compared with the other groups. The PF group exhibited a significantly increased faecal excretion of total steroids. The serum creatinine, level of proteinuria, total cholesterol and LDL-cholesterol concentrations, and blood pressure were significantly reduced, and HDL-cholesterol was significantly increased, in the ISP and PF groups compared with the casein group, but no significant differences were observed between the ISP and PF groups. These results suggest that both soya protein hydrolysate fractions favourably affected chronic renal failure induced by a five-sixths nephrectomy, and the hydrophilic fraction of soya protein hydrolysate had the most pronounced effect on attenuating hypertension and slowing the progression of renal disease.

Keywords

Soya protein hydrolysateRenal failureCholesterolBlood pressure
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 435 - 441
Copyright
Copyright © The Nutrition Society 2006

References

Anderson, JW, Johnstone, BM & Cook-Newell, ME (1995) Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333, 276–282.Google Scholar
Appel, G (1991) Lipid abnormalities in renal disease. Kidney Int 39, 169–183.CrossRefGoogle ScholarPubMed
Aukema, HM, Housini, I & Rawling, JM (1999) Dietary soy protein effects on inherited polycystic kidney disease are influenced by gender and protein level. J Am Soc Nephrol 10, 300–308.Google Scholar
Azadbakht, L, Shakerhosseini, R, Atabak, S, Jamshidian, M, Mehrabi, Y & Esmaill-Zadeh, A (2003) Beneficiary effect of dietary soy protein on lowering plasma levels of lipid and improving kidney function in type II diabetes with nephropathy. Eur J Clin Nutr 57, 1292–1294.CrossRefGoogle ScholarPubMed
Chen, JR, Chiou, SF, Suetsuna, K, Yang, HY & Yang, SC (2003) Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction. Nutrition 19, 676–680.CrossRefGoogle ScholarPubMed
Chen, JR, Okada, OT, Muramoto, K, Suetsuna, K & Yang, SC (2002) Identification of angiotensin I converting enzyme inhibitory peptides derived from the peptic digest of soybean protein. J Food Biochem 26, 543–544.CrossRefGoogle Scholar
Chen, ST, Peng, SJ & Chen, JR (2003) Effects of dietary protein on renal function and lipid metabolism in five-sixths nephrectomized rats. Br J Nutr 89, 491–497.Google Scholar
D'Amico, G, Gentile, MG, Manna, G, Fellin, G, Ciceri, R, Cofano, F, Petrini, C, Lavarda, F, Perolini, S & Porrini, M (1992) Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome. Lancet 339, 1131–1134.Google Scholar
Folch, J, Lees, M & Sloane-Stanley, GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497–509.CrossRefGoogle ScholarPubMed
Gatchalian-Yee, M, Arimura, Y, Ochiai, E, Yamada, K & Sugano, M (1997) Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. Nutrition 13, 633–639.Google Scholar
He, J, Gu, D, Wu, X, Chen, J, Duan, X & Whelton, PK (2005) Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med 143, 1–9.Google Scholar
Ikeda, K, Nara, Y & Yamori, Y (1991) Indirect systolic and mean blood pressure determination by a new tail cuff method in spontaneously hypertensive rats. Lab Anim 25, 26–29.Google Scholar
Klag, MJ, Whelton, PK, Randall, BL, Neaton, JD, Brancati, FL, Ford, CE, Shulman, NB & Stamler, J (1996) Blood pressure and end-stage renal disease in men. N Engl J Med 334, 13–18.CrossRefGoogle ScholarPubMed
Kramer, K & Remie, R (2004) Measuring blood pressure in small laboratory animals, Methods Mol Med 108, 51–62.Google Scholar
Maschio, G, Oldrizzi, L, Rugiu, C, De Biase, V & Loschiavo, C (1991) Effect of dietary manipulation on the lipid abnormalities in patients with chronic renal failure. Kidney Int Suppl 31, S70–S72.Google ScholarPubMed
National Research Council (1985) Guide for the Care and Use of Laboratory Animals, Bethesda, MD: NRC, National Institutes of Health.Google Scholar
Peterson, JC, Adler, S, Burkart, JM, Greene, T, Hebert, LA, Hunsicker, LG, King, AJ, Klahr, S, Massry, SG & Seifter, JL (1995) Blood pressure control, proteinuria, and the progression of renal disease. The modification of diet in renal disease study. Ann Intern Med 123, 754–762.Google Scholar
Potter, SM (1995) Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 125, 606S–611S.Google Scholar
Sugano, M, Goto, S, Yamada, Y, Yoshida, K, Hashimoto, Y, Matsuo, T & Kimoto, M (1990) Cholesterol-lowering activity of various undigested fractions of soybean protein in rats. J Nutr 120, 977–985.Google Scholar
Sugano, M, Yamada, Y, Yoshida, K, Hashimoto, Y, Matsuo, T & Kimoto, M (1988) The hypocholesterolemic action of the undigested fraction of soybean protein in rats. Atherosclerosis 72, 115–122.Google Scholar
Taal, MW & Brenner, BM (2001) Achieving maximal renal protection in nondiabetic chronic renal disease. Am J Kidney Dis 38, 1365–1371.Google Scholar
Teixeira, SR, Tappenden, KA, Carson, L, Jones, R, Prabhudesai, M, Marshall, WP & Erdman, JW Jr (2004) Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy. J Nutr 134, 1874–1880.CrossRefGoogle ScholarPubMed
Tomobe, K, Philbrick, DJ, Ogborn, MR, Takahashi, H & Holub, BJ (1998) Effect of dietary soy protein and genistein on disease progression in mice with polycystic kidney disease. Am J Kidney Dis 31, 55–61.CrossRefGoogle ScholarPubMed
Tovar, AR, Murguia, F, Cruz, C, Hernandez-Pando, R, Aguilar-Salinas, CA, Pedraza-Chaverri, J, Correa-Rotter, R & Torres, N (2002) A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome. J Nutr 132, 2562–2569.Google Scholar
Walser, M (1990) Progression of chronic renal failure in man. Kidney Int 37, 1195–1210.Google Scholar
Wright, JT Jr, Bakris, G, Greene, T, et al. (2002) Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study. JAMA 288, 2421–2431.Google Scholar
Yang, G, Shu, XO, Jin, F, Zhang, X, Li, HL, Li, Q, Gao, YT & Zheng, W (2005) Longitudinal study of soy food intake and blood pressure among middle-aged and elderly Chinese women. Am J Clin Nutr 81, 1012–1017.Google Scholar
Yang, HY, Yang, SC, Chen, JR, Tzeng, YH & Han, BC (2004) Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats. Br J Nutr 92, 507–512.CrossRefGoogle ScholarPubMed