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Efficacy of oral iodised oil is associated with anthropometric status in severely iodine-deficient schoolchildren in rural Malawi

Published online by Cambridge University Press:  09 March 2007

Carina A. Furnée ,
Clive E. West ,
Frits van der Haar  and
Joseph G. A. J. Hautvast
Clive E. West
Affiliation:
Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, PO Box 8129 6700 EV Wageningen, The Netherlands
Joseph G. A. J. Hautvast
Affiliation:
Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, PO Box 8129 6700 EV Wageningen, The Netherlands
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Abstract

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The effect of anthropometric status on the efficacy of an oral supplement of iodised oil (1 ml Lipiodol Ultrafluide, 490 mg I; Laboratoire Guerbet, Aulnay-sous-Bois, France) was examined in 8–10-year-old schoolchildren (n 197) of Ntcheu, a severely I-deficient district of Malawi. The study was a controlled trial using the I concentration of casual urine samples to monitor the I status. The median urinary I concentration increased from 0·15 μmol/l at baseline (51·3 % of children < 0·16 μmol/l, 89·7 % < 0·40 μmol/l, 95·7 % 0·79 μmol/l) to 0·32 μmol/l at 40 weeks (29·1 % of the children < 0·16 μmol/l, 71·0 % < 0·40 μmol/l, 96·1 % < 0·79 μmol/l) while the total goitre prevalence fell from 63 % to 21 %. Variables of efficacy were estimated from a hyperbolic function describing the longitudinal pattern of urinary I excretion after the dose. The I retention and I elimination rate, and the periods of protection from mild (< 0·79 μmol/l) or moderate (< 0·40 μmol/l) I deficiency were obtained for groups of children with differing anthropometric status at baseline. Initial height-for-age and mid upper-arm circumference were not significantly related to efficacy. However, both the I retention and I elimination rate were reduced in children with lower initial weight-for-height. Children with lower skinfold thickness at baseline also had reduced I retention, which resulted in shorter protection periods from recurrent moderate and mild I deficiency. The efficacy of the oral iodised-oil supplement was not related to changes in anthropometric status during follow-up, nor was it related to the consumption of a food supplement of 1610 kJ immediately before the iodised-oil dose. Very low (< 0·16 μmol/l) urinary I concentration, and the presence of goitre at baseline were both associated with higher I retention and elimination rate. Children with goitre at baseline were found to have a prolonged duration of protection against recurrent moderate I deficiency. We conclude that in apparently healthy schoolchildren in I-deficient areas, general anthropometric status has a little influence on the efficacy of oral iodised oil for correcting I deficiency.

Keywords

Iodine deficiencyOral iodised oilUrinary iodine excretion
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 3 , September 2000 , pp. 345 - 352
Copyright
Copyright © The Nutrition Society 2000

References

Bautista, A, Barker, PA, Dunn, JT, Sanchez, M and Kaiser, DL (1982) The effects of oral iodised oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goiter.American Journal of Clinical Nutrition 35, 127–134.CrossRefGoogle ScholarPubMed
Benmiloud, M, Chaouki, ML, Gutekeunst, R, Teichert, H-M, Wood, WG and Dunn, JT (1994) Oral iodised oil for correcting iodine deficiency: Optimal dosing and outcome indicator selection.Journal of Clinical Endocrinology and Metabolism 79, 20–24.Google ScholarPubMed
Benotti, J, Benotti, N, Pino, S and Gasdyna, H (1965) Determination of total iodine in urine, stool, diet, and tissue.Clinical Chemistry 11, 932–936.CrossRefGoogle ScholarPubMed
Delange, FBastani, SBenmiloud, MDeMaeyer, EIsayama, MGKoutras, DMuzzo, SNiepomniszcze, HPandav, CS & Riccabona, G (1986) Definitions of endemic goiter and cretinism, classification of goiter size and severity of endemias, and survey techniques. In Towards the Eradication of Endemic Goiter, Cretinism, and Iodine Deficiency. Scientific Publication 502, pp. 373–375 [Dunn, JT, Pretell, EA, Daza, CH and Viteri, FE, editors]. Washington, DC: Pan American Health Organization.Google Scholar
Dunn, JT (1987) Iodised oil in the treatment and prophylaxis of IDD. In The Prevention and Control of Iodine Deficiency Disorders pp. 127–134 [Hetzel, BS, Dunn, JT and Stanbury, JB, editors]. Amsterdam: Elsevier.Google Scholar
Elnagar, B, Eltom, M, Karlson, FA, Ermans, AM, Gebre-Medhin, M and Bourdoux, PP (1995) The effects of different doses of oral iodised oil on goiter size, urinary iodine, and thyroid-related hormones.Journal of Clinical Endocrinology and Metabolism 80, 891–897.Google ScholarPubMed
Eltom, M, Karlsson, FA, Kamal, AM, Boström, H and Dahlberg, PA (1985) The effectiveness of oral iodised oil in the treatment and prophylaxis of endemic goitre.Journal of Clinical Endocrinology and Metabolism 61, 1112–1117.CrossRefGoogle Scholar
Furné, CA, Pfann, GA, West, CE, Van der Haar, F, Van der Heide, D and Hautvast, JGAJ (1995) New model for describing urinary iodine excretion: its use for comparing different oral preparations of iodised oil.American Journal of Clinical Nutrition 61, 1257–1262.CrossRefGoogle Scholar
Furné, CA, Van der Haar, F, West, CE and Hautvast, JGAJ (1994) A critical appraisal of goiter assessment and the ratio of urinary iodine to creatinine for evaluating iodine status.American Journal of Clinical Nutrition 59, 1415–1417.CrossRefGoogle Scholar
Ingbar, SH (1989) Effects of iodine: Autoregulation of the thyroid. In The Thyroid, A Fundamental and Clinical Text 5th ed., pp. 205–215 [Werner, SC and Ingbar, SH, editors]. Washington, DC: Hagerstown.Google Scholar
Jelliffe, DB & Jelliffe, EFP (1989) Community Nutritional Assessment; With Special to Less Technically Developed Countries. Oxford: Oxford University Press.Google Scholar
Kleinbaum, DGKupper, LL & Muller, KE (1988) Applied Regression Analysis and Other Multivariate Methods. Boston, MA: PWS-Kent Publishing Company.Google Scholar
Koutras, DA (1986) Iodine: distribution, availability, and effects of deficiency on the thyroid. In Towards the Eradication of Endemic Goiter, Cretinism and Iodine Deficiency, Scientific Publication 502, pp. 15–27 [Dunn, JT, Pretell, EA, Daza, CH and Viteri, FE, editors]. Washington, DC: Pan American Health Organization.Google Scholar
Moxon, RED and Dixon, EJ (1980) Semi-automatic method for the determination of total iodine in food.Analyst 105, 344–352.CrossRefGoogle ScholarPubMed
Reichel, A and Seer, OR (1970) Zur enteralen Pasage iodierter oliger Kontrastmittel und ihre Darstellung im Ductus Thoracicus bei der Katze (A study of the gastrointestinal metabolism of iodine and its uptake by the thyroid gland of cats using X-ray photography).Radiologischer Diagnostik 1, 17.Google Scholar
Sandell, EB and Kolthoff, IM (1937) Microdetermination of iodine by catalytic method.Mikrochimica Acta 1, 9–25.CrossRefGoogle Scholar
Van der, Heiden, D, De Goeje, MJ and Van der Bent, C (1989) The effectiveness of orally administered iodised oils in rat and man.Annales d'Endocrinologie 50,(2) Astr no 63.Google Scholar
Watanabe, TMoran, DEl-Tamer, EStaneloni, LSalveneschi, JAltshuler, NDegrossi, OJ & Niepominiszcze, H (1974) Iodised oil in the prophylaxis of endemic goiter in Argentina. In Endemic Goiter and Cretinism: Continuing Threats to World Health. Scientific Publication 292, pp. 231–241 [Dunn, JT and Medeiros-Neto, GA, editors]. Washington, DC: Pan American Health Organization.Google Scholar
World Health Organization (1983) Measuring Change in Nutritional Status; Guidelines for Assessing the Nutritional Impact of Supplementary Feeding Programmes for Vulnerable Groups. Geneva: WHO.Google Scholar
World Health Organization/United Nations International Children's Emergency Fund/International Council for Control of Iodine Deficiency Disorders (1994) Indicators for Assessing Iodine Deficiency Disorders and their Control Through Salt Iodization, Document WHO/NUT/94.6. Geneva: WHO.Google Scholar