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Essential fatty acids in the nutrition of severely neurologically disabled children

Published online by Cambridge University Press:  09 March 2007

Jardar Hals*
Affiliation:
Department of Paediatrics, Buskerud Central Hospital, 3004 Drammen, Norway
K. S. Bjerve
Affiliation:
Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norway
H. Nilsen
Affiliation:
Department of Clinical Nutrition, Tromsø University Hospital, Tromsø, Norway
A. G. Svalastog
Affiliation:
Buskerud Central Hospital, 3004 Drammen, Norway
J. Ek
Affiliation:
Department of Paediatrics, Buskerud Central Hospital, 3004 Drammen, Norway
*
*Corresponding author: Dr Jardar Hals, fax +47 3280 3105, email Jardar.hals@bss.helse.buskerud-f.telemax.no
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Abstract

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Since the food habits of many elderly people are inadequate, the first experiment of the present study tested whether flavour amplification induces changes in preferences for and consumption of food and thus might result in a nutritional benefit. Two panels, one of 260 and one of 120 subjects, aged 19–98 years, took part in the study in which preferences for flavour-amplified yoghurt and Quorn® were measured. For both products, only a few of the young subjects (20 %) preferred the high flavour level; the percentage of subjects preferring the high flavour levels increased with age. These changes were highly significant. In a second experiment, participants received, under ad libitum conditions over 2 d in random order, a dish of yoghurt with either a high or a low flavour level. When adjusted for total consumption quantity, consumption of the highly flavoured yoghurt was not significantly correlated with age (r -0·03, P = 0·35). In a third experiment, odour perception was measured by determining the detection threshold for isoamylacetate. BMI values were obtained and the relationships between BMI and odour perception, age, preference and consumption were assessed in the age group 40–65 years. A significant correlation was observed between age and BMI (r 0·51, P < 0·0005). No significant correlation was observed between BMI and relative consumption of highly flavoured yoghurt (r -0·14, P = 0·14). A significant correlation was observed between BMI and preference for flavour-amplified yoghurt (r 0·35, P < 0·001). However, no significant correlation was observed between BMI and odour perception (r 0·07, P = 0·32). With increasing age, a combined influence of age, sex, BMI and odour perception on food preference is to be expected. According to our multiple regression analysis, BMI showed a significant partial regression coefficient (standardized β 0·36, P = 0·03). In conclusion, flavour amplification of food for older adults deserves attention, but specific approaches, which are tailored to the candidate food systems and older adult target groups, are needed.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2000

References

Agostoni, C, Trojan, S, Bellu, R, Riva, E and Giovannini, M (1995) Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long-chain polyunsaturated fatty acids. Pediatric Research 38, 262266.CrossRefGoogle ScholarPubMed
Aman, MG, Mitchell, EA and Turbott, SH (1987) The effects of essential fatty acid supplementation by Efamol in hyperactive children. Journal of Abnormal Child Psychology 15, 7590.CrossRefGoogle ScholarPubMed
Andersen, LF, Solvoll, K and Drevon, CA (1996) Very-long-chain. n-3 fatty acids as biomarkers for intake of fish and. n-3 fatty acid concentrates. American Journal of Clinical Nutrition 64, 305311.CrossRefGoogle ScholarPubMed
Berg, K (1973) Nutrition of children with reduced physical activity due to cerebral palsy. Bibliotheca Nutriteo et Dieta 19, 1220.Google Scholar
Bjerve, KS, Brubakk, AM, Fougner, KJ, Johnsen, H, Midthjell, K and Vik, T (1993) Omega-3 fatty acids: essential fatty acids with important biological effects, and serum phospholipid fatty acids as markers of dietary ω3-fatty acid intake American Journal of Clinical Nutrition 57 (Suppl.), 801S806S.Google Scholar
Bjerve, KS, Fischer, S and Alme, K (1987) Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. American Journal of Clinical Nutrition 46, 570576.CrossRefGoogle ScholarPubMed
Bjerve, KS, Fischer, S, Wammer, F and Egeland, T (1989) α-Linolenic acid and long-chain ω-3 fatty acid supplementation in three patients with ω-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. American Journal of Clinical Nutrition 49, 290300.CrossRefGoogle ScholarPubMed
Bjerve, KS, Thoresen, L and Børsting, S (1988) Linseed and cod liver oil induced rapid growth in a 7-year old girl with. n-3 fatty acid deficiency. Journal of Parenteral and Enteral Nutrition 12, 521525.CrossRefGoogle Scholar
Blaker, B & Rimestad, AH (1991) Food Composition Tables. Oslo: National Nutrition Council.Google Scholar
Bønaa, KH, Bjerve, KS and Nordøy, A (1992) Habitual fish consumption, plasma phospholipid fatty acids and serum lipids: the Tromsø study. American Journal of Clinical Nutrition 55, 11261134.CrossRefGoogle ScholarPubMed
Bønaa, KH, Bjerve, KS and Nordøy, A (1992) Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. Arteriosclerosis and Thrombosis 12, 675681.CrossRefGoogle ScholarPubMed
Carlson, SE, Werkman, SH, Rhodes, PG and Tolley, EA (1993) Visual-acuity development in healthy preterm infants: effect of marine oil supplementation. American Journal of Clinical Nutrition 58, 3542.CrossRefGoogle ScholarPubMed
Carlson, SE and Wilson, WW (1994) Docosahexaenoic acid supplementation of preterm infants: effect on the 12-month Bayley mental developmental index. Pediatric Research 35, 20A.Google Scholar
Connor, WE, DeFrancesco, CA and Connor, SL (1993). N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Annals of the New York Academy of Sciences 683, 1634.CrossRefGoogle ScholarPubMed
Crawford, MA, Costeloe, K, Doyle, W, Leighfield, MJ, Lennon, EA and Meadows, N (1990) Potential diagnostic value of the umbilical artery as a definition of neural fatty acid status of the fetus during its growth: the umbilical artery as a diagnostic tool. Biochemical Society Transactions 18, 761766.CrossRefGoogle ScholarPubMed
Crawford, MA, Doyle, W, Drury, P, Lennon, A, Costeloe, K and Leighfield, M (1989) n-6 and n-3 fatty acids during early human development. Journal of Internal Medicine 225 (Suppl. 1), 159169.CrossRefGoogle Scholar
Decsi, T and Koletzko, B (1994) Polyunsaturated fatty acids in infant nutrition. Acta Pædiatrica 395 (Suppl.), 3137.CrossRefGoogle Scholar
Decsi, T and Koletzko, B (1995) Growth, fatty acid composition of plasma lipid classes, and plasma retinol and α-tocopherol concentrations in full-term infants fed formula enriched with ω-6 and ω-3 long-chain polyunsaturated fatty acids. Acta Pædiatrica 84, 725732.CrossRefGoogle ScholarPubMed
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonnemann, G, van der Meer, JW, Canon, JG, Rogers, TS, Klempner, MS, Weber, PC, Schaefer, EJ, Sheldon, MW and Dinarello, CA (1989) The effect of dietary supplementation with. n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265271.CrossRefGoogle ScholarPubMed
Hagve, TA and Christophersen, BO (1984) Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. Biochimica et Biophysica Acta 796, 205217.CrossRefGoogle ScholarPubMed
Hals, J, Ek, J, Svalastog, AG and Nilsen, H (1996) Studies on nutrition in severely neurologically disabled children in an institution. Acta Pædiatrica 85, 14691475.CrossRefGoogle ScholarPubMed
Harris, WS (1989) Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. Journal of Lipid Research 30, 785807.CrossRefGoogle ScholarPubMed
Holman, RT (1978) How essential are essential fatty acids?. Journal of the American Oil Chemists' Society 55, 774A780A.CrossRefGoogle ScholarPubMed
Koletzko, B (1997). Trans-fatty acids. Dietary fats in infancy and childhood. Annales Nestlé 55, 6372.Google Scholar
Koletzko, B, Edenhofer, S, Lipowsky, G and Reinhardt, D (1995) Effects of a low birthweight infant formula containing human milk levels of docosahexaenoic and arachidonic acids. Journal of Pediatric Gastroenterology and Nutrition 21, 200208.Google ScholarPubMed
Makrides, M, Neumann, M, Simmer, K, Pater, R and Gibson, R (1995) Are long-chain polyunsaturated fatty acids essential nutrients in infancy?. Lancet 345, 14631468.CrossRefGoogle ScholarPubMed
Martinez, M (1991) Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. In Health Effects of Omega-3 Polyunsaturated Fatty Acids in Seafoods, pp. 87102 [Simopoulos, AP, Kifer, RR, Martin, RE and Barlow, SM, editors]. Basel: Karger.Google Scholar
Mead, JF and Slaton, WH (1955) Metabolism of essential fatty acids III. Isolation of 5,8,11-eicosatrienoic acid from fat-deficient rats. Journal of Biology and Chemistry 219, 705709.CrossRefGoogle Scholar
Mitchell, EA, Aman, MG, Turbott, SH and Manku, M (1987) Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clinical Pediatrics 26, 426431.CrossRefGoogle ScholarPubMed
National Research Council (1989) Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy of Sciences.Google Scholar
Neuringer, M, Connor, WE, Lin, DS, Barstad, L and Luck, S (1986) Biochemical and functional effects of prenatal and postnatal ω3 fatty acid deficiency on retina and brain in rhesus monkeys. Proceedings of the National Academy of Sciences USA 83, 40214025.CrossRefGoogle Scholar
Rivers, JPW and Frankel, TL (1981) Essential fatty acid deficiency. British Medical Bulletin 37, 5964.CrossRefGoogle ScholarPubMed
Robinson, DR (1987) Lipid mediators of inflammation. Rheumatic Diseases Clinics of North America 13, 385405.CrossRefGoogle ScholarPubMed
Sandstrøm, BM, Aro ABecker, W, Lyhne, N, Pedersen, JI & Tòrsdòttir, I (1996) Nordiska Näringsrekommendationer NORD 28, 1415.Google Scholar
Shrapnel, WS, Calvert, GD, Nestel, PJ and Truswell, AS (1992) Diet and coronary heart disease. Medical Journal of Australia 156 (Suppl.), 916.CrossRefGoogle ScholarPubMed
Statens livsmedelsverk (1993) Livsmedeltabell, Energi och Næringsemmen (Table of Food Energy and Nutrition). Uppsala: Statens livsmedelsverk.Google Scholar
Stevens, LJ, Zentall, SS, Deck, JL, Abate, ML, Watkins, BA, Lipp, SR and Burgess, JR (1995) Essential fatty acid metabolism in boys with attention deficit–hyperactivity disorder. American Journal of Clinical Nutrition 62, 761768.CrossRefGoogle ScholarPubMed
Svennerholm, L (1968) Distribution and fatty acid composition of phosphoglycerides in normal human brain. Journal of Lipid Research 9, 570579.CrossRefGoogle ScholarPubMed
Svensson, BG, Akesson, B, Nilsson, A and Skerfving, S (1993) Fatty acid composition of serum phosphatidylcholine in healthy subjects consuming varying amounts of fish. European Journal of Clinical Nutrition 47, 132140.Google ScholarPubMed
Uauy-Dagach, R, Mena, P and Hoffmann, DR (1994) Essential fatty acid metabolism and requirements for LBW infants. Acta Pædiatrica 405 (Suppl.), 7885.CrossRefGoogle ScholarPubMed
Willatts, P, Forsyth, JS, CiModugno, MK, Varma, S and Colvin, M (1998) Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at ten months of age. Lancet 352, 688691.CrossRefGoogle Scholar