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Formula-feeding reduces lactose digestive capacity in neonatal pigs

Published online by Cambridge University Press:  08 March 2007

Thomas Thymann ,
Douglas G. Burrin ,
Kelly A. Tappenden ,
Charlotte R. Bjornvad ,
Søren K. Jensen  and
Per T. Sangild
Thomas Thymann*
Affiliation:
Division of Human NutritionRoyal Veterinary and Agricultural UniversityRolighedsvej 30DK-1958 Frederiksberg CDenmark
Douglas G. Burrin
Affiliation:
US Department of Agriculture/Agricultural Research ServiceChildren's Nutrition Research CenterHoustonTX 77030USA
Kelly A. Tappenden
Affiliation:
Department of Food Science and Human Nutrition/Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA
Charlotte R. Bjornvad
Affiliation:
Division of Human NutritionRoyal Veterinary and Agricultural UniversityRolighedsvej 30DK-1958 Frederiksberg CDenmark
Søren K. Jensen
Affiliation:
Department of Animal HealthWelfare and NutritionDanish Institute of Agricultural SciencesTjeleDK-8830Denmark
Per T. Sangild
Affiliation:
Division of Human NutritionRoyal Veterinary and Agricultural UniversityRolighedsvej 30DK-1958 Frederiksberg CDenmark
*
*Corresponding author: Dr Thomas Thymann, fax +45 35283020, Email ttn@kvl.dk
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Abstract

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The intestine of newborn pigs develops rapidly during the first days postpartum. We investigated if feeding milk replacer (infant formula) as an alternative to colostrum has compromising effects on nutrient digestive function in the neonatal period. Nineteen piglets born at termwere assigned to one of four treatments: (1) newborn controls; (2) natural suckling for 24h; (3) tube-fed formula for 24h; (4) tube-fed porcine colostrum for 24h. All three fed groups showed significant increases in small-intestinal and colonic weights, villous heights and widths, maltase and aminopeptidase A activities, and decreases in dipeptidylpeptidase IV activity, relative to newborn pigs. Following oral boluses of mannitol, lactose or galactose, formula-fed pigs showed significantly reduced plasma levels of mannitol and galactose compared with colostrum-fed pigs. Activity of intestinal inducible NO synthase and plasma levels of cortisol were significantly increased, whereas intestinal constitutive NO synthase and α-tocopherol were decreased in formula-fed pigs compared with colostrum-fed pigs. Although formula-fed pigs only showed minor clinical signs of intestinal dysfunction and showed similar intestinal trophic responses just after birth, as those fed colostrum, lactose digestivecapacity was markedly reduced. We conclude that formula-feeding may exert detrimental effects on intestinal function in neonates. Formula-induced subclinical malfunction of the gut in pigsborn at term was associated with altered NO synthase activity and antioxidative capacity.

Keywords

Formula-feedingLactoseIntestineNeonatal pigs
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 6 , June 2006 , pp. 1075 - 1081
Copyright
Copyright © The Nutrition Society 2006

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