Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-28T03:22:28.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Gene–nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E ε4-carrying free-living individuals

Published online by Cambridge University Press:  09 March 2007

Alexandre Loktionov ,
Serena Scollen ,
Nicola McKeown  and
Sheila A. Bingham
Alexandre Loktionov*
Affiliation:
Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, UK
Serena Scollen
Affiliation:
Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, UK
Nicola McKeown
Affiliation:
Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, UK
Sheila A. Bingham
Affiliation:
Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, UK
*
*Corresponding author: Dr A. Loktionov, fax +44(0)1223 252765, email alex.loktionov@mrc-dunn.cam.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Apolipoprotein E (ApoE) genotype influence on the relationship between dietary risk factors for cardiovascular disease and blood serum lipid levels was investigated in 132 free-living individuals participating in the European Prospective Investigation of Cancer (EPIC) study. All subjects (age 40–69) were clinically healthy and provided information on their usual diet. ApoE genotype and serum lipid concentrations were determined in all subjects. Relationships of intake of dietary constituents with serum lipid levels were compared in different genotype groups. There was a significant correlation between total serum cholesterol and intake of energy derived from total fat (r 0·195; P 0·025) and saturated fat (r 0·174; P 0·046) in the cohort as a whole. However, individuals with the ApoE ε3/ε4 genotype displayed a much stronger positive correlation between LDL cholesterol level and the percentage of energy derived from intake of saturated fat (r 0·436; P 0·043). There were no significant associations in the groups with ε3/ε3 or ε2/ε2 & ε2/ε3 genotype. A significant positive correlation between alcohol consumption and HDL cholesterol level was present in individuals bearing ApoE ε2 allele. These findings support current public health recommendations that saturated fat consumption should be reduced in order to reduce coronary heart disease risk. Total cholesterol concentrations were positively related to saturated fat intake in the cohort as a whole, but elevated LDL cholesterol levels associated with high saturated fat intake can be expected particularly in those individuals who combine a ‘risky’ dietary behaviour with the presence of the ε4 variant of ApoE.

Keywords

GenotypeDietary fatSerum cholesterol
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 6 , December 2000 , pp. 885 - 890
Copyright
Copyright © The Nutrition Society 2000

References

Berger, K, Adjani, UA, Kase, C, Gaziano, JM, Buring, JE, Glynn, RJ & Hennekens, CH (1999) Light-to-moderate alcohol consumption and the risk of stroke among US male physicians. New England Journal of Medicine 341, 1557–1564.CrossRefGoogle ScholarPubMed
Bohnet, K, Regis-Bailly, A, Vincent-Viry, M, Schlenck, A, Gueguen, R, Siest, G & Visvikis, S (1996) Apolipoprotein E genotype ɛ4/ɛ2 in the STANISLAS cohort study – dominance of the ɛ2 allele?. Annals of Human Genetics 60, 509–516.CrossRefGoogle Scholar
Castelli, WP (1996) Lipids, risk factors and ischaemic heart disease. Atherosclerosis 124, Suppl., S1–S9.CrossRefGoogle ScholarPubMed
Castelli, WP, Garrison, RJ, Wilson, PWF, Abbott, RD, Kalousdian, S & Kannel, WB (1986) Incidence of coronary heart disease and lipoprotein cholesterol levels: the Framingham study. JAMA 256, 2835–2838.CrossRefGoogle ScholarPubMed
Choudhury, SR, Ueshima, H, Kita, Y, Kobayashi, KM, Okayama, A, Yamakawa, M, Hirao, Y, Ishikawa, M & Miyoshi, Y (1994) Alcohol intake and serum lipids in a Japanese population. International Journal of Epidemiology 23, 940–947.CrossRefGoogle Scholar
Clarke, R, Frost, C, Collins, R, Appleby, P & Peto, R (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. British Medical Journal 314, 112–117.CrossRefGoogle ScholarPubMed
Corbo, RM & Scacchi, R (1999) Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thirty' allele?. Annals of Human Genetics 63, 301–310.CrossRefGoogle Scholar
Day, NE, Oakes, S, Luben, R, Khaw, KT, Bingham, S, Welch, A & Wareham, N (1999) EPIC in Norfolk: Study Design and Characteristics of the Cohort. British Journal of Cancer 80, Suppl. 1, 95–103.Google ScholarPubMed
Dreon, DM, Fernstrom, HA, Miller, B & Krauss, RM (1995) Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet. Arteriosclerosis, Thrombosis and Vascular Biology 16, 105–111.CrossRefGoogle Scholar
Gylling, H & Miettinen, T (1992) Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotype. Journal of Lipid Research 33, 1361–1371.CrossRefGoogle Scholar
Hallman, DM, Boerwinkle, E, Saha, N, Sanholzer, C, Menzel, HJ, Csazar, A & Utermann, G (1991) The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. American Journal of Human Genetics 49, 338–349.Google ScholarPubMed
Harjai, KJ (1999) Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine, lipoprotein(a), triglycerides, oxidative stress, and fibrinogen. Annals of Internal Medicine 131, 376–386.CrossRefGoogle ScholarPubMed
LaRosa, JC, Hunninghake, D, Bush, D, Criqui, MH, Getz, GS, Gotto, AM, Grundy, SM, Rakita, L, Robertson, RM, Weisfeldt, ML & Cleeman, JI (1990) The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease: A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. Circulation 81, 1721–1733.CrossRefGoogle ScholarPubMed
Linn, S, Carroll, M, Johnson, C, Fulwood, R, Kalsbeek, W & Briefel, R (1993) High-density-lipoprotein cholesterol and alcohol consumption in United States white and black adults – Data from NHANES-II. Am J Publ Health 83, 811–816.CrossRefGoogle ScholarPubMed
Loktionov, A, Bingham, SA, Vorster, H, Jerling, JC, Runswick, SA & Cummings, JH (1998) Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot study. British Journal of Nutrition 79, 133–139.CrossRefGoogle ScholarPubMed
Loktionov, A, Vorster, H, O'Neill IK, Nell, T, Bingham, SA, Runswick, SA & Cummings, JH (1999) Apolipoprotein E and methylenetetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans. Atherosclerosis 145, 125–135.CrossRefGoogle ScholarPubMed
Mayer, EJ, Newman, B, Quesenberry, CP, Friedman, GD & Selby, JV (1993) Alcohol consumption and insulin concentrations – Role of insulin in associations of alcohol intake with high-density-lipoprotein cholesterol and triglycerides. Circulation 88, 2190–2197.CrossRefGoogle ScholarPubMed
McGill, HC (1979) The relationship of dietary cholesterol to serum cholesterol concentration and to atherosclerosis in man. American Journal of Clinical Nutrition 32, 2664–2702.CrossRefGoogle ScholarPubMed
Muntwyler, J, Hennekens, CH, Buring, JE & Gaziano, JM (1998) Mortality and light to moderate alcohol consumption after myocardial infarction. Lancet 352, 1882–1885.CrossRefGoogle ScholarPubMed
Pasagian-Macaulay, A, Aston, CE, Ferrell, RE, McAllister, AE, Wing, RR & Kuller, LH (1997) A dietary and behavioral intervention designed to lower coronary heart disease. Risk factors are unaffected by variation at the APOE gene locus. Atherosclerosis 132, 221–227.CrossRefGoogle ScholarPubMed
Patsch, JR (1993) Ishypertriglyceridemia atherogenic?. Atherosclerosis Reviews 25, 331–339.Google Scholar
Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy (COMA) (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects41, Department of Health. HMSO: London.Google Scholar
Report of the Cardiovascular Review Group of the Committee on Medical Aspects of Food Policy (COMA) (1994) Nutritional Aspects of Cardiovascular Disease. Report on Health and Social Subjects46, Department of Health. HMSO: London.Google Scholar
Ross, R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801–809.CrossRefGoogle ScholarPubMed
Sarkkinen, E, Korhonen, M, Erkkilä, Ebeling, T & Uusitupa, M (1998) Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. American Journal of Clinical Nutrition 68, 1215–1222.CrossRefGoogle Scholar
Savolainen, MJ, Rantala, M, Kervinen, K, Jarvi, L, Suvanto, K, Rantala, T & Kesaniemi, YA (1991) Magnitude of dietary effects on plasma cholesterol concentration: role of sex and apolipoprotein E phenotype. Atherosclerosis 86, 145–152.CrossRefGoogle ScholarPubMed
Thun, MJ, Peto, R, Lopez, AD, Monaco, JH, Henley, SJ, Heath, CW & Doll, R (1997) Alcohol consumption and mortality among middle-aged and elderly US adults. New England Journal of Medicine 337, 1705–1714.CrossRefGoogle Scholar
Tikkanen, MJ, Huttunen, JK, Ehnholm, C & Pietinen, P (1990) Apolipoprotein E4 homozygosity predisposes to serum cholesterol elevation during high fat diet. Arteriosclerosis 10, 285–288.CrossRefGoogle ScholarPubMed
Weisgraber, KH & Mahley, RW (1996) Human apolipoprotein E: The Alzheimer's disease connection. FASEB Journal 10, 1485–1494.CrossRefGoogle ScholarPubMed
Wilson, PF, Myers, RH, Larson, MH, Ordovas, JM, Wolf, PA & Schaefer, EJ (1994) Apolipoprotein E alleles, dyslipidemia and coronary heart disease. The Framingham Offspring Study. JAMA 272, 1666–1671.CrossRefGoogle ScholarPubMed
Wilson, PWF, Schaeffer, EJ, Larson, MG, Ordovas, JM, (1996) Apolipoprotein-e alleles and risk of coronary disease – a metaanalysis. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1250–1255.CrossRefGoogle ScholarPubMed