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Glutamine: essential for immune nutrition in the critically ill

Published online by Cambridge University Press:  09 March 2007

Francis J. Andrews  and
Richard D. Griffiths
Francis J. Andrews
Affiliation:
Intensive Care Research Group, Department of Medicine, Duncan Building, UCD, Daulby Street, University of Liverpool, L69 3GA, UK
Richard D. Griffiths*
Affiliation:
Intensive Care Research Group, Department of Medicine, Duncan Building, UCD, Daulby Street, University of Liverpool, L69 3GA, UK
*
*Corresponding author: Dr R. D. Griffths, fax +44 (0) 151 706 5802, email rdg@liverpool.ac.uk
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Abstract

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Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S1 , January 2002 , pp. S3 - S8
Copyright
Copyright © The Nutrition Society 2002

References

Ardawi, MSM (1988) Glutamine and glucose metabolism in peripheral blood lymphocytes. Metabolism 37, 99–103.CrossRefGoogle Scholar
Askanazi, J, Carpentier, YA, Michelsen, CB, Elwyn, DH, Furst, P, Kantrowitz, LR, Gump, FE & Kinney, JM (1980) Muscle and plasma amino acids following injury. Annals of Surgery 192, 78–85.CrossRefGoogle ScholarPubMed
Biolo, G, Fleming, RYD, Maggi, SP, Nguyen, TT, Herndon, DN & Wolfe, RR (2000) Inhibition of muscle glutamine formation in hypercatabolic patients. Clinical Science 99, 189–194.CrossRefGoogle ScholarPubMed
Bone, RC (1996) Sir Isaac Newton, Sepsis, SIRS, and CARS. Critical Care Medicine 24, 1125–1127.CrossRefGoogle Scholar
Chang, WK, Yang, KD & Shaio, MF (1999a) Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clinical Immunology 93, 294–301.CrossRefGoogle ScholarPubMed
Chang, WK, Yang, KD & Shaio, MF (1999b) Lymphocyte proliferation modulated by glutamine: involved in the endogenous redox reaction. Clinical and Experimental Immunology 117, 482–488.CrossRefGoogle ScholarPubMed
Ditschkowski, M, Kreuzfelder, E, Regmann, V, Ferencik, S, Majestschak, M, Schmid, EN, Obertacke, U, Hirche, H, Schade, UF & Grosse-Wide, H (1999) HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Annals of Surgery 229, 246–254.CrossRefGoogle ScholarPubMed
Ferguson, NR, Galley, HF & Webster, NR (1999) T-helper cell subset ratios in patients with severe sepsis. Intensive Care Medicine 25, 106–109.CrossRefGoogle ScholarPubMed
Fujishima, S & Aikawa, N (1995) Neutrophil-mediated tissue injury and its modulation. Intensive Care Medicine 21, 277–285.CrossRefGoogle ScholarPubMed
Furukawa, S, Saito, H, Fukatsu, K, Hashiguchi, Y, Inaba, T, Lin, MT, Inoue, T, Han, I, Matsuda, T & Muto, T (1997) Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition 13, 863–869.CrossRefGoogle ScholarPubMed
Furukawa, S, Saito, H, Inoue, T, Matsuda, T, Fukatsu, K, Han, I, Ikeda, S & Hidemura, A (2000) Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition 16, 323–329.CrossRefGoogle ScholarPubMed
Giannoudis, PV, Smith, RM, Perry, SL, Windsor, AJ, Dickson, RA & Bellamy, MB (2000) Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intensive Care Medicine 26, 1076–1081.CrossRefGoogle ScholarPubMed
Giannoudis, PV, Smith, RM, Windsor, AC, Bellamy, MC & Gillou, PJ (1999) Monocyte Human Leucocyte antigen-DR expression correlates with intrapulmonary shunting after major trauma. American Journal of Surgery 177, 455–459.CrossRefGoogle ScholarPubMed
Griffiths, RD, Allen, KD & Jones, C (2000) Glutamine TPN and intensive care acquired infections. Clinical Nutrition 19, 42 (abstract 172).Google Scholar
Griffiths, RD, Jones, C & Palmer, TEA (1997) Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 4, 296–302.Google Scholar
Hammarqvist, F, Wernerman, J, Custom, A, Von der Deacon, A & Vines, E (1989) Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Annals of Surgery 209, 455–461.CrossRefGoogle ScholarPubMed
Hershman, MJ, Cheadle, WG, Wellhausen, SR, Davidson, PF & Polk, HC (1990) Monocyte HLA-DR antigen expression characterises clinical outcome in the trauma patient. British Journal of Surgery 77, 204–207.CrossRefGoogle ScholarPubMed
Houdijk, APJ, Nijveldt, RJ & van Leeuwen, PAM (1999) Glutamine-enriched enteral feeding in trauma patients: reduced infectious morbidity is not related to changes in endocrine and metabolic responses. Journal of Parenteral and Enteral Nutrition 23, S52–S58.CrossRefGoogle Scholar
Houdijk, APJ, Rijnsburger, ER, Jansen, J, Wesdorp, RIC, Weis, JK, McCamish, MA, Teerlink, T, Meuwissen, SG, Haarman, Hj, Thijs, LG & van Leeuwen, PA (1998) Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 352, 772–776.CrossRefGoogle ScholarPubMed
Kew, S, Wells, S, Yaqoob, P, Wallace, FA, Miles, EA & Calder, PC (1999) Dietary glutamine enhances murine T-lymphocyte responsiveness. Journal of Nutrition 129, 1524–1531.CrossRefGoogle ScholarPubMed
Kox, WJ, Volk, T, Kox, SN & Volk, HD (2000) Immunomodulatory therapies in sepsis. Intensive Care Medicine 26:S103–S110.CrossRefGoogle ScholarPubMed
Lacey, JM & Wilmore, DW (1990) Is glutamine a conditionally essential amino acid?. Nutrition Reviews 48, 297–309.CrossRefGoogle ScholarPubMed
Levy, EM, Alharbi, SA, Grindlinger, G & Black, PH (1984) Changes in mitogen responsiveness lymphocyte subsets after traumatic injury: relation to development of sepsis. Clinical Immunology and Immunopathology 32, 224–233.CrossRefGoogle ScholarPubMed
Lin, RY, Astir, ME, Saxon, JC & Rack, EC (1993) Altered leucocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14 and IL-2R expression. Chest 104, 847–853.CrossRefGoogle ScholarPubMed
Marie, C, Muret, J, Fitting, C, Losser, MR, Payen, D & Cavaillon, JM (1998) Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome. Blood 91, 3439–3446.CrossRefGoogle ScholarPubMed
McKeehan, WL (1982) Glycolysis, glutaminolysis and cell proliferation. Cell Biology International Reports 6, 635–647.CrossRefGoogle ScholarPubMed
Mittendorfer, B, Gore, DC, Herndon, DN & Wolfe, RR (1999) Accelerated glutamine synthesis in critically ill patients cannot maintain normal intra muscular free glutamine concentration. Journal of Parenteral and Enteral Nutrition 23, 243–250.CrossRefGoogle Scholar
Morlion, BJ, Stehle, P, Wachter, P, Siedhoff, HP, Köller, M, König, W, Fürst, P & Puchstein, C (1998) Total parenteral nutrition with glutamine dipeptide after major abdominal surgery. Annals of Surgery 227, 302–308.CrossRefGoogle ScholarPubMed
Mossmann, TR & Coffman, RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7, 145–173.CrossRefGoogle Scholar
Muller Kobold, AC, Tulleken, JE, Zijlstra, JG, Sluiter, W, Hermans, J, Kallenberg, CG & Cohen Tervaert, JW (2000) Leucocyte activation in sepsis; correlations with disease state and mortality. Intensive Care Medicine 26, 883–892.CrossRefGoogle ScholarPubMed
Neidhardt, R, Keel, M, Steckholzer, U, Safret, A, Ungethuem, U, Tentz, O & Ertel, W (1997) Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. Journal of Trauma 42, 863–870.CrossRefGoogle ScholarPubMed
Neu, J, Roig, JC, Meetze, WH, Veerman, M, Carter, C, Millsaps, M, Bowling, D, Dallas, MJ, Sleasman, J, Knight, T & Auestad, N (1997) Enteral glutamine supplementation for very low birthweight infants decreases morbidity. Journal of Pediatrics 131, 691–699.CrossRefGoogle ScholarPubMed
Newsholme, EA, Crabtree, B & Ardawi, MSM (1985) The role of high rates of glycolysis and glutamine utilisation in rapidly dividing cells. Bioscience Reports 5, 393–400.CrossRefGoogle ScholarPubMed
Newsholme, EA, Crabtree, B & Ardawi, MSM (1987) Rates of utilisation and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochemical Journal 242, 631–636.CrossRefGoogle ScholarPubMed
Newsholme, P, Curi, R, Pithon Curi, TC, Murphy, CJ, Garcia, C & Pires de Melo, M (1999) Glutamine metabolism by lymphocytes, macrophages and neutrophils: its importance in health and disease. Journal of Nutritional Biochemistry 10, 316–324.CrossRefGoogle ScholarPubMed
Ogle, CK, Ogle, JD, Mao, JX, Simon, J, Noel, JG, Li, BG & Alexander, JW (1994) Effect of glutamine on phagocytosis and bacterial killing by normal and paediatric burn patient neutrophils. Journal of Parenteral and Enteral Nutrition 18, 128–133.CrossRefGoogle ScholarPubMed
O’Riordain, MG, Fearon, KCH, Ross, JA, Rogers, P, Falconer, JS, Bartolo, DCC, Garden, OJ & Carter, DC (1994) Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Annals of Surgery 220, 212–221.CrossRefGoogle ScholarPubMed
O’Sullivan, ST, Lederer, JA, Horgan, AF, Chin, DH, Mannick, JA & Rodrick, ML (1995) Major injury leads to predominance of the T-helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Annals of Surgery 222, 482–490.CrossRefGoogle ScholarPubMed
Parry-Billings, M, Evans, J, Calder, P & Newsholme, EA (1990) Does glutamine contribute to immunosuppression after major burns?. Lancet 336, 523–525.CrossRefGoogle ScholarPubMed
Peters, M, Petros, A, Dixon, G, Inwald, D & Klein, N (1999) Acquired immunoparalysis in paediatric intensive care: prospective observational study. British Medical Journal 319, 609–610.CrossRefGoogle ScholarPubMed
Pithon Curi, TC, Pires de Melo, M, De Azevedo, R, Zorn, TMT & Curi, R (1997) Glutamine utilization by rat neutrophils: Presence of phosphate-dependent glutaminase. American Journal of Physiology 273, C1124–C1129.CrossRefGoogle Scholar
Sherry, RM, Cue, JI, Goddard, JK, Parramore, JB & DiPiro, JT (1996) Interleukin-10 is associated with the development of sepsis in trauma patients. Journal of Trauma 40, 613–616.CrossRefGoogle ScholarPubMed
Simms, HH & D’Amico, R (1997) Posttraumatic auto-oxidative polymorphonuclear neutrophil receptor injury predicts the development of nosocomial infection. Archives of Surgery 132, 171–177.CrossRefGoogle ScholarPubMed
Spittler, A, Winkler, S, Gotzinger, P, Oehler, R, Willheim, M, Tempfer, C, Weigel, G, Fugger, R, Boltz-Nitulescu, G & Roth, E (1995) Influence of glutamine on the phenotype and function of human monocytes. Blood 86, 1564–1569.CrossRefGoogle ScholarPubMed
Stinnett, JD, Alexander, JW, Watanabe, C, MacMillan, BG, Fischer, JE, Morris, MJ, Trocki, O, Miskell, P, Edwards, L & James, H (1982) Plasma and skeletal muscle aminoacids following severe burn injury in patients and experimental animals. Annals of Surgery 195, 75–89.CrossRefGoogle ScholarPubMed
Tschaikowsky, K, Sittl, R, Braun, GG, Hering, W & Rügheimer, E (1993) Increased fMet-leu-phe receptor expression and altered superoxide of neutrophil granulocytes in septic and posttraumatic patients. Clinical Investigation 72, 18–25.Google ScholarPubMed
Van Acker, BAC, von Meyenfeldt, MF, van der Hulst, RRWJ, Hulsewé, KWE, Wagenmakers, AJM, Deutz, NEP, de Blaauw, I, Dejong, CHC, van Kreel, BK & Soeters, PB (1999) Glutamine: the pivot of our nitrogen economy?. Journal of Parenteral and Enteral Nutrition 23, S45–S48.CrossRefGoogle ScholarPubMed
Vlessis, AA, Goldman, RK & Trunkey, DD (1995) New concepts in the pathophysiology of oxygen metabolism during sepsis. British Journal of Surgery 82, 870–876.CrossRefGoogle ScholarPubMed
Wakefield, CH, Carey, PD, Foulds, S, Monson, JRT, Gillou, PJ (1993) Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. British Journal of Surgery 77, 204–207.Google Scholar
Wallace, C & Keast, D (1992) Glutamine and macrophage function. Metabolism 41, 1016–1020.CrossRefGoogle ScholarPubMed
Weingartmann, G, Oehler, R, Derkits, S, Oismüller, C, Függer, R, Roth, E (1999) HSP70 expression in granulocytes and lymphocytes of patients with polytrauma: comparison with plasma glutamine. Clinical Nutrition 18, 121–124.CrossRefGoogle ScholarPubMed
Wernerman, J, Hammarqvist, F (1999) Glutamine: a necessary nutrient for the intensive care patient. International Journal of Colorectal Disease 14, 137–142.CrossRefGoogle ScholarPubMed
Ziegler, TR, Young, LS, Benfell, K, Scheltinga, M, Hortos, K, Bye, R, Morrow, FD, Jacobs, DO, Smith, RJ, Antin, JH & Wilmore, DW (1992) Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. Annals of Internal Medicine 116, 821–828.CrossRefGoogle ScholarPubMed