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Immunohistochemical detection of changes in growth hormone cells in rat pituitaries in protein deficiency

Published online by Cambridge University Press:  25 March 2008

Therese Drummond
Therese Drummond
Affiliation:
Instituto de Nutrição, Universidade Federal de Pernarnbuco, Recife, Pernambuco, Brazil
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Abstract

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1. An immunohistochemical method was used to study the effect of a low-protein diet on growth hormone (GH) cells in the pituitaries of developing rats. The deficient diet (80 g protein/kg) was administered during gestation and lactation, or during the time after weaning until 90 d of age, or during both periods.

2. GH-cell changes were much more striking in males than in females.

3. In males, GH-producing cells were usually reduced in size and number in all treatments. The effect was most intense when protein deprivation occurred throughout gestation and sucking, and continued until 90 d of age, but it was also evident in animals given the low protein diet only after weaning. Recuperation appeared to be almost complete when offspring of deprived dams were fed on a normal diet after weaning.

4. It is concluded that a low-protein diet reduces the amount of GH in the rat pituitary in a way similar to that with a protein-free diet.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 33 , Issue 1 , January 1975 , pp. 11 - 15
Copyright
Copyright © The Nutrition Society 1975

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