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Impaired T lymphocyte immune response in vitamin A depleted rats and chicks

Published online by Cambridge University Press:  09 March 2007

Aharon Friedman  and
David Sklan
Aharon Friedman
Affiliation:
Department of Animal Science, Faculty of Agriculture, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
David Sklan
Affiliation:
Department of Animal Science, Faculty of Agriculture, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
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Abstract

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Vitamin A deficiency results in decreased immune responses; the objective of the present study was to investigate the involvement of T lymphocytes in the depression of immune responses resulting from vitamin A depletion. This objective was achieved by evaluating antigen-specific T lymphocyte proliferative responses in vitro as vitamin A depletion developed. The evaluation was performed in both rat and chick to examine the generality of immune effects due to vitamin A depletion. Our findings show that vitamin A depletion led to severe impairment of T lymphocyte activity in both animal models, and that this was directly related to the vitamin A status in both species. Immune response impairment was found to precede other manifestations of vitamin A deficiency, and was rapidly corrected by feeding retinyl acetate boluses. This implied a possible regulatory, rather than constitutive, role of vitamin A in immune responsiveness.

Keywords

Immune responseRatChickT lymphocytesRetinol
Type
Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 2 , September 1989 , pp. 439 - 449
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Athanassiades, T.J. (1981). Adjuvant effect of vitamin A palmitate and analogs on cell mediated immunity. Journal of the National Cancer Institute 67, 1153–1156.Google Scholar
Bang, B.G., Bang, F.B. & Foard, M.A. (1972). Lymphocyte depression induced in chickens on diets deficient in vitamin A and other components. American Journal of Pathology 68, 147–162.Google ScholarPubMed
Bang, B.G., Foard, M.A. & Bang, F.B. (1973). The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in the chicken. Proceedings of the Society for Experimental Biology and Medicine 143, 1140–1146.Google Scholar
Barnett, J.B. (1983). Immunomodulating effects of 13-cis-retinoic acid on the IgG and IgM response of BALB/c mice. International Archives of Allergy and Applied Immunology 72, 227–233.Google Scholar
Barnett, J.B. & Bryant, R.L. (1980). Adjuvant and immunosuppressive effects of retinol and Tween 80 on IgG production in mice. International Archives of Allergy and Applied Immunology 63, 145–152.CrossRefGoogle ScholarPubMed
Bartlett, A., Bidwell, D.E. & Voller, A. (1976). Practical methods for the detection of antigens by ELISA. In Protides of the Biological Fluids, vol. 24, pp. 767–770 [Peeters, H., editor]. Oxford: Pergamon Press.Google Scholar
Cohen, B.E. & Cohen, I.K. (1973). Vitamin A: adjuvant and steroid antagonist in the immune response. Journal of Immunology 111, 1376–1380.Google Scholar
Colizzi, V. & Malkovsky, M. (1985). Augmentation of interleukin-2 production and delayed hypersensitivity in mice infected with Mycobacterium bovis and fed a diet supplemented with vitamin A acetate. Infection and Immunity 48, 581–583.Google Scholar
Davis, C.Y. & Sell, J.L. (1983). Effect of all trans retinol and retinoic acid on the immune system of chicks. Journal of Nutrition 113, 1914–1919.Google Scholar
Dennert, C., Crowley, C., Kouba, J. & Lotan, R. (1979). Retinoic acid stimulation of the induction of mouse killer T-cells in allogeneic and syngeneic systems. Journal of the National Cancer Institute 62, 89–94.Google Scholar
Dennert, G. (1984). Retinoids and the immune system: immunostimulation by vitamin A. In The Retinoids, vol. 2, pp. 373–390 [Sporn, M.B., Roberts, A.B. and Goodman, D.S., editors]. London: Academic Press.Google Scholar
Friedman, A. & Cohen, I.R. (1983). Molecular events in the processing of avidin by antigen presenting cells. I. The immune response of T lymphocytes to avidin is regulated by H-2 linked Ir genes. Immunogenetics 18, 267–276.Google Scholar
Friedman, A., Zerubavel, R., Gitler, C. & Cohen, I.R, (1983). Molecular events in the processing of avidin by antigen presenting cells. III. Activation of T lymphocyte lines and H-2 restriction are mediated by processed antigen associated with I-region gene products. Immunogenetics 18, 291–302.Google Scholar
Goldman, R. (1984). Effect of retinoic acid on the proliferation and phagocytic capability of murine macrophage-like cell lines. Journal of Cellular Physiology 120, 91–102.Google Scholar
Goldman, R. (1985). Enhancement of colony stimulating factor-dependent clonal growth of murine macrophage progenitors and their phagocytic activity by retinoic acid. Journal of Cellular Physiology 123, 288–296.Google Scholar
Harmon, B.G., Miller, E.R., Hoefer, J.A., Ullrey, D.E. & Luecke, R.W. (1963). Relationship of specific nutrient deficiencies to antibody production in swine. I. Vitamin A. Journal of Nutrition 79, 263–268.Google Scholar
Leutskaya, Z.K. & Fais, D. (1977). Antibody synthesis stimulation by vitamin A in chickens. Biochimica et Biophysica Acta 475, 207–216.Google Scholar
Lotan, R. & Dennert, G. (1979). Stimulatory effects of vitamin A analogs on the induction of cell mediated cytotoxicity in-vivo. Cancer Research 39, 55–58.Google ScholarPubMed
Malkovsky, M., Edwards, A.J., Hunt, R., Palmer, L. & Medawar, P.B. (1983). T-cell-mediated enhancement of host-versus-graft reactivity in mice fed a diet enriched in vitamin A acetate. Nature 302, 338–340.Google Scholar
Maron, R., Zerubavel, R., Friedman, A. & Cohen, I.R. (1983). T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. Journal of Immunology 131, 2316–2322.Google Scholar
Moore, W.T., Murtaugh, M.P. & Davies, P.J.A. (1984). Retinoic-acid induced expression of tissue transglutaminase in mouse peritoneal macrophages. Journal of Biological Chemistry 259, 12794–12802.Google Scholar
Nauss, K.M., Mark, D.A. & Suskind, R.M. (1979). The effect of vitamin A deficiency on the in-vitro cellular response of rats. Journal of Nutrition 109, 1815–1823.Google Scholar
Nauss, K.M. & Newberne, P.M. (1985). Local and regional immune function of vitamin A deficient rats with occular herpes simplex virus (HSV) infections. Journal of Nutrition 115, 1316–1324.Google Scholar
Nauss, K.M., Phua, C.-C., Ambrogi, L. & Newberne, P.M. (1985). Immunological changes during progressive stages of vitamin A deficiency in the rat. Journal of Nutrition 115, 909–918.Google Scholar
Panda, B. & Combs, G.F. (1986). Impaired antibody production in chicks fed with diets low in vitamin A, pantothenic acid or riboflavin. Proceedings of the Society for Experimental Biology and Medicine 113, 530–534.CrossRefGoogle Scholar
Shapiro, P.E. & Edelson, R.L. (1985). Effects of retinoids on the immune system. In Retinoids: New Trends in Research and Therapy. Retinoid Symposium, Geneva, pp. 225–235 [Saurat, A.H., editor]. Basel: KargerGoogle Scholar
Sharon, N. (1983). Lectin receptors as lymphocyte surface markers. Advances in Immunology 34, 213–298.Google Scholar
Sirisinha, S., Darip, M.D., Moongkarndi, P., Ongsakul, M. & Lamb, A.J. (1980). Impaired local immune response in vitamin A deficient rats. Clinical and Experimental Immunology 40, 127–135.Google Scholar
Sklan, D. (1987). Vitamin A in human nutrition. Progress in Food and Nutrition Science 11, 39–55.Google Scholar
Sklan, D. & Halevy, O. (1984). Vitamin A metabolism in chick liver: some properties of the cytosolic lipid-protein aggregate. British Journal of Nutrition 52, 107–114.Google Scholar
Sklan, D., Halevy, O. & Donoghue, S. (1987). The effect of different dietary levels of vitamin A on metabolism of copper, iron and zinc in the chick. International Journal of Vitamin and Nutrition Research 57, 11–18.Google Scholar
Smith, S.M. & Hayes, C.E. (1987). Contrasting impairments in IgM and IgG responses of vitamin A deficient mice. Proceedings of the National Academy of Sciences, USA 84, 5878–5882.Google Scholar
Smith, S.M., Levy, N.S. & Hayes, C.E. (1987). Impaired immunity in vitamin A deficient mice. Journal of Nutrition 117, 857–865.Google Scholar
Uhr, J.W., Weissmann, G. & Thomas, L. (1963). Acute hypervitaminosis A in guinea pigs. II. Effect on delayed type hypersensitivity. Proceedings of the Society for Experimental Biology and Medicine 112, 287–291.Google Scholar
Wirth, J.J. & Kierszenbaum, F. (1986). Stimulatory effects of retinoic acid on macrophage interaction with blood forms of Trypanosoma cruzi: involvement of transglutaminase activity. Journal of Immunology 137, 3326–3331.Google Scholar
Wolf, G. (1984). Multiple functions of vitamin A. Physiological Reviews 64, 873–937.Google Scholar