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Importance of folate in human nutrition

Published online by Cambridge University Press:  09 March 2007

Kamala Krishnaswamy  and
K. Madhavan Nair
Kamala Krishnaswamy*
Affiliation:
National Institute of Nutrition, Jamai-Osmania, Hyderabad-500007, India
K. Madhavan Nair
Affiliation:
National Institute of Nutrition, Jamai-Osmania, Hyderabad-500007, India
*
*Corresponding author: Dr Kamala Krishnaswamy, fax +91 40 7019074, email icmrnin@ren.nic.in, nin@ap.ap.nic.in
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Abstract

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From a public health perspective, some of the new insights into folic acid nutrition are of significance. Folate intake recommendations vary under different conditions. Intake of 350 μg is required to maintain plasma homocysteine levels, 650 μg for those with elevated plasma homocysteine, about 400 μg for women planning to become pregnant and 4000 μg for those with history of neural tube defect affected pregnancy. This raises the question whether the folate intake is adequate for the general population, particularly in the vulnerable groups or whether there is a need for scientists to take a fresh view of the requirements, recommended dietary intakes, and consider intervention measures which will have impact on the folate nutritional status. The recommendations should provide a margin of safety to allow for decreased intake, increased requirements, individual variability and bioavailability of natural food folates. The folate intake and nutriture in relation to India and other developing countries needs careful consideration to reduce anemia, neural tube defects and possibly impact on the high incidence of cardiovascular diseases.

Keywords

FolateHomocysteineHealth and diseaseRDAIndia
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue S2 , May 2001 , pp. S115 - S124
Copyright
Copyright © The Nutrition Society 2001

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