Hostname: page-component-745bb68f8f-lrblm Total loading time: 0 Render date: 2025-01-27T22:13:50.816Z Has data issue: false hasContentIssue false
  • English
  • Français

In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence

Published online by Cambridge University Press:  09 March 2007

Antonius C. M. van Hooijdonk ,
K. D. Kussendrager  and
J. M. Steijns
Antonius C. M. van Hooijdonk*
Affiliation:
DMV International, R&D Center, PO Box 13, 5460 BA Veghel, The Netherlands
K. D. Kussendrager
Affiliation:
DMV International, R&D Center, PO Box 13, 5460 BA Veghel, The Netherlands
J. M. Steijns
Affiliation:
DMV International, Center of Expertise for Nutrition, PO Box 14, 6700 AA Wageningen, The Netherlands
*
*Corresponding author: A. C. M. van Hooijdonk, email hooydonk@dmv-international.com
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The in vivo evidence of the antimicrobial and antiviral activity of bovine milk and colostrum derived components are reviewed with special emphasis on lactoferrin and lactoperoxidase. Their mode of action and the rationale for their application in efficacy trials with rodents, farm animals, fish and humans, to give protection against infectious agents, are described. A distinction is made between efficacy obtained by oral and non-oral administration of these non-specific defence factors which can be commercially applied in large quantities due to major achievements in dairy technology. From the in vivo studies one can infer that lactoferrin and lactoperoxidase are very promising, naturally occurring antimicrobials for use in fish farming, husbandry, oral hygiene and functional foods. Other promising milk-derived compounds include lipids, from which anti-infective degradation products are generated during digestion, and antimicrobial peptides hidden in the casein molecules.

Keywords

BovineMilkColostrumAntimicrobialAntiviralLactoferrinLactoperoxidaseLipids
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue S1 , November 2000 , pp. 127 - 134
Copyright
Copyright © The Nutrition Society 2000

References

Arnold, RR, Brewer, R & Gauthier, JJ (1980) Bactericidal activity of human lactoferrin: sensitivity of a variety of micro-organisms. Infection and Immunity 28, 893–898.CrossRefGoogle Scholar
Boxer, LA, Coates, TD, Haak, RA, Wolach, JB, Hoffstein, S & Baehner, RL (1982) Lactoferrin deficiency associated with altered granulocyte function. New England Journal of Medicine 307, 404–410.Google Scholar
Breton-Gorius, J, Mason, DY, Buriot, D, Vilde, J-L & Griscelli, C (1980) Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. American Journal of Pathology 99, 413–419.Google Scholar
Bullen, JJ (1987) Iron and the antibacterial function of polymorphonuclear leucocytes Iron and Infection, pp. 211–241, [Bullen, JJ and riffiths, EG, editors]. New York: John Wiley.Google Scholar
Bullen, JJ, Rogers, HJ & Leigh, L (1972) Iron-binding proteins in milk and resistance to Escherichia coli infection in infants. British Medical Journal i, 69–75.Google Scholar
Courtois, P, VanBeers, D, DeFloor, M, Mandelbaum, IM & Pourtois, M (1990) Abolition of herpes simplex cytopathic effect after treatment with peroxidase generated hypothiocyanate. Journal de Biologie Buccale 18, 71–74.Google Scholar
Dahlberg, PA, Bergmark, A, Björck, L, Bruce, A, Hambraeus, L & Claesson, O (1984) Intake of thiocyanate by way of milk and its possible effect of thyroid function. American Journal of Clinical Nutrion 39, 416.Google ScholarPubMed
Debbabi, H, Dubarry, M, Rautureau, M, Tomé, D (1998) Bovine lactoferrin induces both mucosal and systemic immune response in mice. Journal of Dairy Research 65, 283–293.Google Scholar
De Wit, JN, Van Hooydonk, ACM (1996) Structure, functions and applications of lactoperoxidase in natural antimicrobial systems. Netherlands Milk and Dairy Journal 50, 227–244.Google Scholar
Edwards, CA, Parrett, AM, Balmer, SE & Wharton, BA (1994) Faecal short chain fatty acids in breast-fed and formula-fed babies. Acta Pædiatrica 83, 459–462.CrossRefGoogle ScholarPubMed
Gaunt, PN & Seal, DV (1984) Mechanisms of host defense against respiratory infection. International Anesthesiology Clinics 22, 113–129.CrossRefGoogle ScholarPubMed
Hoogendoorn, H (1985) Activation of the salivary peroxidase antimicrobial system: clinical studies The Lactoperoxidase System, pp. 217–227 [Pruitt, KM and Tenovuo, JO, editors] New York: Marcel Dekker.Google Scholar
Isaacs, CE, Litov, RE & Thormar, H (1995) Antimicrobial activity of lipids added to human milk, infant formula and bovine milk. Journal of Nutritional Biochemistry 6, 362–366.Google Scholar
Kakuta, I (1998) Reduction of stress response in carp, Cyprinus carpio L., held under deteriorating environmental conditions, by oral administration of bovine lactoferrin. Journal of Fish Diseases 21, 161–167.Google Scholar
Kivinen, A, Tarpila, S, Salminen, S & Vapaatalo, H (1992) Gastroprotection with milk phospholipids: a first human study. Milchwissenschaft 47, 694–696.Google Scholar
Klebanoff, SJ (1970) Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes. Science 169, 1095–1097.CrossRefGoogle Scholar
Lee, WL, Farmer, JL, Hilty, M & Kim, YB (1998) The protective effects of lactoferrin feeding against endotoxin lethal shock in germfree piglets. Infection and Immunity 66, 1421–1426.Google Scholar
Leriander-Lumikari, M, Tenovuo, J & Mikola, H (1993) Effects of lactoperoxidase system containing toothpaste on levels of hypothiocyanite and mutans Streptococci in saliva. Caries Research 27, 285–291.CrossRefGoogle Scholar
Levay, PF & Viljoen, M (1995) Lactoferrin: a general review. Haematologica 80, 252–267.Google ScholarPubMed
Li, YM, Tan, AX & Vlassara, H (1995) Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation-modified proteins to a conserved motif. Nature Medicine 1, 1057–1061.CrossRefGoogle ScholarPubMed
Lönnerdal, B (1996) Breast feeding and formulas: the role of lactoferrin? Iron Nutrition in Health and Disease. Proceedings of the 20th International symposium of the Swedish Nutrition Foundation, pp. 313–323 [Hallberg, L and Asp, N-G, editors]. London: John Libbey & Company.Google Scholar
Lönnerdal, B & Iyer, S (1995) Lactoferrin: molecular structure and biological function. Annual Review of Nutrition 15, 93–110.Google Scholar
Lu, L, Hangoc, G, Oliff, A, Chen, LT, Shen, R-N & Broxmeyer, HE (1987) Protective influence of lactoferrin on mice infected with the polycythemia-inducing strain of Friend virus complex. Cancer Research 47, 4184–4188.Google ScholarPubMed
Machnicki, M, Zimecki, M & Zagulski, T (1993) Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo. International Journal of Experimental Pathology 74, 433–439.Google ScholarPubMed
Naidu, AS & Arnold, RR (1997) Influence of lactoferrin on host-microbe interactions Lactoferrin: Interactions and Biological Functions, pp. 259–275 , [Hutchens, TW and Lönnerdal, B, editors] New Jersey: Humana Press.Google Scholar
Ohtaki, S, Nakagawa, H & Yamazaki, I (1980) Reaction of detergent-stabilized thyroid peroxidase with hydrogen peroxide. FEBS Letters 109, 71–74.Google Scholar
Pruitt, KM & Reiter, B (1985) Biochemistry of peroxidase system: antimicrobial effects The Lactoperoxidase System, pp. 143–178 , [Pruitt, KM and Tenovuo, JO, editors]. New York: Marcel Dekker.Google Scholar
Reiter, B (1985) The biological significance of the non-immunoglobulin protective proteins in milk: lysozyme, lactoferrin, lactoperoxidase. Development in Dairy Chemistry 3, 281–336.Google Scholar
Reiter, B & Bramley, AJ (1975) Document 85 Seminar on Mastisis Control, pp. 210–215 [Dodd, FH, Griffin, TKKingwill, RG, editors].Reading: IDF.Google Scholar
Reiter, B, Fulford, RJ, Marshall, VM, Yarrow, N, Ducker, MJ & Knutsson, M (1981) An evaluation of the growth promoting effect of the lactoperoxidase system in newborn calves. Animal Production and Health Newsletter 32, 297.Google Scholar
Reiter, B & Oram, JD (1967) Bacterial inhibitors in milk and other biological fluids. Nature 216, 328–330.Google Scholar
Reiter, B & Perraudin, J-P (1991) Lactoperoxidase: biological functions Peroxidases in Chemistry and Biology, pp. Vol. 1, 143–180 [Everse, J, Everse, KE and Grisham, MB, editors]. Boca Raton: CRC Press.Google Scholar
Renner, E, Schaafsma, G & Scott, KJ (1989) Micronutrients in milk Micronutrients in Milk and Milk-based Food Products, pp. 1–70 [Renner, E, editors] New York: Elsevier Applied Science.Google Scholar
Roberts, AK, Chierici, R, Sawatzki, G, Hill, MJ, Volpato, S & Vigi, V (1992) Supplementation of an adapted formula with bovine lactoferrin: 1. Effect on the infant faecal flora. Acta Pædiatrica 81, 119–124.Google Scholar
Rudloff, S & Kunz, C (1997) Protein and nonprotein nitrogen components in human milk, bovine milk and infant formula: quantitative and qualitative aspects in infant nutrition. Journal of Pediatric Gastroenterology and Nutrition 24, 328–344.Google ScholarPubMed
Rudney, JD, Ji, Z, Larson, CJ, Liljemark, WF & Hickey, KL (1995) Saliva protein binding to layers of oral Streptococci in vitro and in vivo. Journal of Dental Research 74, 1280–1288.CrossRefGoogle ScholarPubMed
Rytomaa, T & Teir, H (1961) Relation between tissue eosinophils and peroxidase activity. Nature 192, 271–272.Google Scholar
Sakai, M, Kobayashi, M & Yoshida, T (1995) Activation of rainbow trout, Oncorhynchus mykiss, phagocytic cells by administration of bovine lactoferrin. Comparative Biochemistry and Physiology 110, 755–759.Google Scholar
Sakai, M, Otubo, T, Atsuta, S & Kobayashi, M (1993) Enhancement of resistance to bacterial infection in rainbow trout, Oncorhynchus mykiss (Walbaum), by oral administration of bovine lactoferrin. Journal of Fish Diseases 16, 239–247.Google Scholar
Sánchez, L, Calvo, M & Brock, JH (1992) Biological role of lactoferrin. Archives of Disease in Childhood 67, 657–661.Google Scholar
Schanbacher, FL, Talhouk, RS & Murray, FA (1997) Biology and origin of bioactive peptides in milk. Livestock Production Science 50, 105–123.CrossRefGoogle Scholar
Shimizu, K, Matsuzawa, H, Okada, K, Tazume, S, Dosako, S, Kawasaki, Y, Hashimoto, K & Koga, Y (1996) Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity. Archives of Virology 141, 1875–1889.CrossRefGoogle ScholarPubMed
Spitznagel, JK, Cooper, MR, McCall, AE, Dechatelet, LR & Welsh, IRH (1972) Selective deficiency of granules with lysozyme and lactoferrin in human polymorphs (PMN) with reduced microbicidal capacity. European Journal of Clinical Investigation 51, 93a.Google Scholar
Sprong, C, Hulstein, M & VanderMeer, R (1998) Phospholipid-rich butter milk decreases the gastro-intestinal survival and translocation of Listeria in rats. Gastroenterology 114, A10090.Google Scholar
Stanislawski, M, Rousseau, V, Goavec, M & Ito, HO (1989) Immunotoxins containing glucose oxidase and lactoperoxidase with tumoricidal properties: in vitro killing effectiveness in a mouse plasmacytoma cell model. Cancer Research 49, 5497–5504.Google Scholar
Still, J, Delahaut, P, Coppe, P, Kaeckenbeeck, A & Perraudin, JP (1989) Onderzoek naar het effect van het lactoperoxidase-systeem en lactoferrine op geïnduceerde enterotoxigene colibacillose (diarrhee) bij kalveren Dier en Arts Dec., 302–307.Google Scholar
Teraguchi, S, Shin, K, Ozawa, K, Nakamura, S, Fukuwatari, Y, Tsuyuki, S, Namihira, H & Shimamura, S (1995) Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of clostridium species in the gut of mice fed bovine milk. Applied and Environmental Microbiology 61, 501–506.Google Scholar
Teraguchi, S, Shin, K, Ogata, T, Kingaku, M, Kaino, A, Miyauchi, H, Fukuwatari, Y & Shimamura, S (1995) Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk. Applied and Environmental Microbiology 61, 4131–4134.Google Scholar
Tomita, M (1994) Active peptides of lactoferrin. In Proceedings of the IDF seminar: Indigenous antimicrobial agents of milk – Recent Developments, 7–13Brussels: International Dairy Federation.Google Scholar
Trümpler, U, Straub, PW & Rosenmund, A (1989) Antibacterial prophylaxis with lactoferrin in neutropenic patients. European Journal of Clinical Microbiology Infectectious Diseases 8, 310–313.Google Scholar
Van Leeuwen, P, Huisman, J, Kerkhof, HM & Kussendrager, K (1998) Small intestinal microbiological and morphological observations in young calves fed milk replacers enriched with a combination of lactoperoxidase system and lactoferrin. Journal of Animal Feed Sciences 7, 223–228.Google Scholar
VanSteenberghe, D, VandenEynde, E, Jacobs, R & Quiryen, M (1994) Effect of a lactoperoxidase containing toothpaste in radiation-induced xerostomia. International Dental Journal 44, 133–138.Google Scholar
Waterhouse, A & Mullan, WMA (1980) Re-inclusion of an active lactoperoxidase system in milk-substitute diet for calves. Animal Production and Health Newsletter 30, 458.Google Scholar
Waterhouse, A & Mullan, WMA (1980) Addition of an active lactoperoxidase system to a milk substitute diet for calves. Irish Journal of Food Science and Technology 4, 69.Google Scholar
Wolfson, LM & Sumner, SS (1993) Antibacterial activity of the lactoperoxidase system: a review. Journal of Food Protection 56, 887–892.Google Scholar
Zagulski, T, Lipinski, P, Zagulska, A, Broniek, S & Jarzabek, Z (1989) Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. British Journal of Experimental Pathology 70, 697–704.Google ScholarPubMed
Zagulski, T, Lipinski, P, Zagulska, A & Jarzabek, Z (1998) Antibacterial system generated by lactoferrin in mice in vivo is primarily a killing system. International Journal of Experimental Pathology 79, 117–123.Google Scholar
Zagulski, T, Zagulska, A, Jedra, M & Jarzabek, Z (1985) Rabbit plasma iron level after in-vivo administration of lactoferrin. Prace i Materialy Zootechniczne. 36, 95–105.Google Scholar
Zucht, H-D, Raida, M, Aderman, K, Maegert, H-J, Forssman, W-G (1995) Casocidin-I: a casein-αs2 derived peptide exhibits antibacterial activity. FEBS Letters 372, 185–188.Google Scholar