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Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats

Published online by Cambridge University Press:  10 October 2007

Shiguang Yu ,
Clive E. West  and
Anton C. Beynen
Shiguang Yu
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine. Utrecht University, PO Box 80.157. 3508 TD Utrecht, The Netherlands
Clive E. West
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands
Anton C. Beynen
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine. Utrecht University, PO Box 80.157. 3508 TD Utrecht, The Netherlands
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Abstract

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High intakes of Fe may impair Cu status, but the underlying mechanism is not known. Male rats, aged 7 weeks, were given purified diets adequate in Cu (8 mg Cu/kg) and containing either 7, 40 or 389 mg Fe/kg. After 6 weeks the concentrations of Fe in liver and spleen were positively related with dietary Fe level and those of Cu were negatively related with dietary Fe level. Increasing Fe intakes reduced apparent absorption and biliary excretion of Cu in a dose-dependent fashion. In individual rats, biliary Cu excretion showed a significant, positive correlation with Liver Cu concentration. It is concluded that increased Fe intakes depress Cu absorption which produces a decrease in plasma and organ Cu concentrations. As a result, biliary Cu excretion is lowered which contributes to achieving Cu balance at high Fe intakes. Because the concentrations of Cu in plasma and bile, and also plasma ceruloplasmin (EC 1.16.3.1) activities, showed much greater percentage reductions with increasing Fe intake than did the concentrations of Cu in organs, it is possible that increased Fe status interferes with the mobilization of Cu stores.

Keywords

CopperAbsorptionBiliary excretion
Type
Effects of iron intake on copper status
Information
British Journal of Nutrition , Volume 71 , Issue 6 , June 1994 , pp. 887 - 895
Copyright
Copyright © The Nutrition Society 1994

References

Ashworth, A. & March, Y. (1973). Iron fortification of dried skim milk and maize-soya-bean-milk mixture (CSM): availability of iron in Jamaican infants. British Journal of Nutrition 30, 577–584.CrossRefGoogle Scholar
Bremner, I. & Price, J. (1985). Effects of dietary iron supplements on copper metabolism in rats. Truce Elements in Man and Animals 5, 374376.Google Scholar
Bremner, I. & Young, B. J. (1981). Effect of variation in dietary iron concentration on copper metabolism in rats. Proceedings of the Nutrition Society 40, 69A.Google Scholar
Bremner, I., Young, B. W. & Mills, C. F. (1982). The effects of iron and sulphide on copper metabolism in rats. Proceedings of the Nutrition Society 41, 82A.Google Scholar
Brouwer, I. A., Lemmens, A. G. & Beynen, A. C. (1993). Dietary fructose IJ. glucose lowers ferrous-iron absorption in rats. British Journal of Nutrition 70, 171–178.CrossRefGoogle Scholar
Dhur, A., Galan, P. & Hercberg, S. (1989). Effects of doses and duration of iron supplement on iron deficiency in rats. Journal of Clinical Biochemistry trnd Nutrition 7, 193–200.CrossRefGoogle Scholar
Fleck, C. & Barth, A. (1990). Influence of xenobiotics on bile flow and bile composition in rats - methodological approach. Experiniental Pathologv 39, 175–185.Google ScholarPubMed
Guthrie, B. E. & Robinson, M. F. (1977). Daily intakes of manganese, copper, zinc and cadmium by New Zealand women. British Journal of Nutrition 38, 55–63.CrossRefGoogle Scholar
Holden, J. M., Wolf, W. R. & Mertz, W. (1979). Zinc and copper in self-selected diets. Journul of the American Dietetic Association 75, 23–28.CrossRefGoogle ScholarPubMed
Humphries, W. R., Phillippo, M., Young, B. W. & Bremner, I. (1983). The influence of dietary iron and molybdenum on copper metabolism in calves. British Journal of Nutrition 49, 77–86.CrossRefGoogle ScholarPubMed
Johnson, M. A. & Hove, S. S. (1986). Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose. Journal of Nutrition 116, 1225–1238.CrossRefGoogle ScholarPubMed
Johnson, M. A. & Murphy, C. L. (1988). Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats. American Journal of Clinical Nutrition 47, 96–109.CrossRefGoogle ScholarPubMed
Kreuzer, M. & Kirchgessner, M. (1991). Iron retention in tissues and carcass of rats during growth and under different oral and parenteral supply of iron as Fe(III)-hydroxide-polymaltose. Journal of Animal Physiology and Animal Nutrition 65, 96–109.CrossRefGoogle Scholar
Li, T., Wang, W. M. & Yeung, D. L. (1988). Efficacy of iron fortified infant cereals in the prevention of iron deficiency in infants in China. Nutrition Reports International 37, 695–701.Google Scholar
McCance, R. A. & Widdowson, E. M. (1937). Absorption and excretion of iron. Lancet ii, 680–684.CrossRefGoogle Scholar
National Research Council (1978). Nutrient Requirements of Laboratory Animals. Washington, DC: National Academy of Sciences.Google Scholar
Reichlmayer-Lais, A. M. & Kirchgessner, M. (1992). Effekte einer steigenden alimentaren Fe-Zufuhr auf die scheinbare Verdaulichkeit von Fe, Cu, Zn und Mn sowie auf die Gehalte dieser Elemente in Leber und Ganzkorper (Effects of an increasing dietary Fe-supply on the apparent digestibility of Fe, Cu, Zn and Mn, and on the amounts of these elements in liver and whole body). Journal of Aninial Physiologjx and Animal Nutrition 67, 67–73.CrossRefGoogle Scholar
Rios, E., Hunter, R. E., Cook, J. D., Smith, N. J. & Finch, C. A. (1975). The absorption of iron as supplements in infant formulas. Paediutrics 55, 686–693.Google ScholarPubMed
Smith, C. H. & Bidlack, W. R. (1980). Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron and copper in female guinea pigs. Journal of Nutrition 110, 1398–1408.CrossRefGoogle ScholarPubMed
Scrrensen, E. W. (1965). Studies on iron absorption. II. Experiments with iron-deficient and non-deficient rats. Acta Medica Scanditiavicu 178, 385–392.CrossRefGoogle Scholar
SPSS Inc. (1988). Statistical Package,for the Social Sciences, 3rd ed. Chicago: SPSS.Google Scholar
Standish, J. F., Ammerman, C. B.. Simpson, C. F., Neal, F. C. & Palmer, A. Z. (1969). Influence of graded levels of dietary iron, as ferrous sulphate, on performance and tissue mineral composition of steers. Journal of Animal Science 29, 496–503.CrossRefGoogle ScholarPubMed
Sunderman, F. W. & Nomoto, S. (1970). Measurement of human serum ceruloplasmin by itsp-phenylenediamine oxidase activity. Clinical Chemistry 116, 903–910.CrossRefGoogle Scholar
Van den Berg, G. J. & Beynen, A. C. (1992). Influence of ascorbic acid supplementation on copper metabolism in rats. British Journal of Nutrition 68, 701–715.CrossRefGoogle ScholarPubMed