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The influence of dietary folate supplementation on the incidence of teratogenesis in zinc-deficient rats

Published online by Cambridge University Press:  09 March 2007

Patricia B. Quinn ,
F. M. Cremin ,
V. R. O'sullivan ,
F. M. Hewedi  and
R.J. Bond
Patricia B. Quinn
Affiliation:
Department of Nutrition, University College, Cork, Republic of Ireland
F. M. Cremin
Affiliation:
Department of Nutrition, University College, Cork, Republic of Ireland
V. R. O'sullivan
Affiliation:
Department of Anatomy, University College, Cork, Republic of Ireland
F. M. Hewedi
Affiliation:
Faculty of Agriculture, Cairo University, Egypt
R.J. Bond
Affiliation:
Biological Services Unit, University College, Cork, Republic of Ireland
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Abstract

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Two studies were conducted to investigate the possibility that pteroylmonoglutamic acid supplementation would alleviate teratogenesis in zinc-deficient rats. Pregnant rats of the Wistar strain were fed on Zn-deficient (< 0.5 mg Zn/kg) or Zn-supplemented (75 or 95 mg Zn/kg) diets from mating until day 18.5 of gestation. The basal level of pteroylmonoglutamic acid added to all diets (0.56 mg/kg) was supplemented with 30–200 mg/kg in selected diets. Dietary Zn deprivation resulted in fetal resorption, fetal growth retardation and reduced concentrations of Zn in fetuses and maternal plasma and tibia. Low maternal body-weight at conception emerged as an important determinant of risk of resorption in Zn-deficient rats. Dietary Zn deficiency resulted in reduced maternal plasma folate concentrations and these values were inversely correlated with litter size or weight in Zn-deficient rats. Pteroylmonoglutamic acid supplementation increased maternal plasma folate concentrations, but did not reduce the high incidence of teratogenesis which occurred in Zn-deficient rats. Supplementation of Zn-deficient rats with pteroylmonoglutamic acid significantly increased the incidence of clubbed foot and tended to increase the incidence of brain or meningeal abnormalities, or both, and cleft palate, but did not reduce maternal or fetal Zn status. Pteroylmonoglutamic acid supplementation also increased the weights of Zn-supplemented control fetuses.

Keywords

Zinc deficiencyFolate supplementationTeratogenesisRat
Type
Micronutrients
Information
British Journal of Nutrition , Volume 64 , Issue 1 , July 1990 , pp. 233 - 243
Copyright
Copyright © The Nutrition Society 1990

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