Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-26T06:17:28.720Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of magnesium deficiency on horse foal tissue concentrations of Mg, calcium and phosphorus*

Published online by Cambridge University Press:  09 March 2007

D. D. Harrington
D. D. Harrington
Affiliation:
Department of Veterinary Science, Kentucky Agricultural Experimental Station, University of Kentucky, Lexington, Kentucky 40506, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effects of feeding with a purified magnesium-deficient diet (−Mg, 7–8 mg Mg/kg) on horse foal blood serum and tissue concentrations of Mg, calcium and phosphorus were studied, and the results compared with histopathological findings.

2. Serum concentrations of Ca and P were unaffected by feeding with the −Mg diet, whereas serum Mg concentrations decreased from a mean initial (day 0) concentration of 0.78 mmol/l to 0.53 mmol/l 7 d after foals were placed on the −Mg diet, and then continued to decrease at a slower rate.

3. Aorta concentrations of Ca and P, but not Mg, were positively correlated with the period of time foals were given the −Mg diet, verifying histopathological findings. Results for both aorta Ca and P analyses and histopathological studies indicated that mineralization of the aorta began approximately 30–35 d after foals were placed on the −Mg diet.

4. Feeding with the −Mg diet had no significant, analytically detectable effect on brain, liver, kidney, lung, spleen, skeletal or cardiac muscle concentrations of Ca, P or Mg, although microscopic evidence of mineralization was seen in some of these tissues from foals given the −Mg diet for 71–180 d.

5. A significant negative correlation was found between bone ash concentrations of Mg (rib, metacarpus and metatarsus) and the length of time foals were fed on the −Mg diet. Bone ash concentrations of Ca and P were, however, unchanged.

6. Low serum Mg values and negative correlations between the bone ash concentration of Mg and the period of time foals were fed on the −Mg diet supplemented with 390 mg Mg as MgO/kg were interpreted as suggesting that either this level of Mg supplementation is marginal for the growing foal, or that the Mg in MgO is not readily available to the growing foal.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 1 , July 1975 , pp. 45 - 57
Copyright
Copyright © The Nutrition Society 1975

References

Aikawa, J. K., Reardon, J. Z. & Harms, D. R. (1962). J. Nutr. 76, 90.CrossRefGoogle Scholar
Blaxter, K. L., Rook, J. A. F. & MacDonald, A. M. (1954). J. comp. Path. Ther. 64, 157.CrossRefGoogle Scholar
Bradbury, M. W. B., Kleeman, C. R., Bagdoyan, H. & Berberian, A. (1968). J. Lab. clin. Med. 71, 884.Google Scholar
Breibart, S., Lee, J. S., McCoord, A. & Forbes, G. B. (1960). Proc. Soc. exp. Biol. Med. 105, 361.CrossRefGoogle Scholar
Britton, W. M. & Stokstad, E. L. R. (1970). J. Nutr. 100, 1501.CrossRefGoogle Scholar
Bunce, G. E., Chiemchaisri, Y. & Phillips, P. H. (1962). J. Nutr. 76, 23.CrossRefGoogle Scholar
Bunce, G. E., Jenkins, K. J. & Phillips, P. H. (1962). J. Nutr. 76, 17.CrossRefGoogle Scholar
Duckworth, J. & Godden, W. (1941). Biochem. J. 35, 816.CrossRefGoogle Scholar
Fiske, C. H. & Subbarow, Y. (1925). J. biol. Chem. 66, 375.CrossRefGoogle Scholar
Gerken, H. J. & Fontenot, J. P. (1967). J. Anim. Sci. 26, 1404.CrossRefGoogle Scholar
Grace, N. D. & O'Dell, B. L. (1970). J. Nutr. 100, 37.CrossRefGoogle Scholar
Green, H. H., Allcroft, W. M. & Montgomerie, R. F. (1935). J. comp. Path. Ther. 48, 74.CrossRefGoogle Scholar
Hamuro, Y., Shino, A. & Suzuoki, Z. (1970). J. Nutr. 100, 404.CrossRefGoogle Scholar
Harrington, D. D. (1974). Am. J. vet. Res. 35, 503.Google Scholar
Harrington, D. D., Walsh, J. J., Marroquin, C. R. & White, V. (1973). J. Anim. Sci. 37, 280.Google Scholar
Heggtveit, H. A. (1969). Ann. N. Y. Acad. Sci. 162, 758.CrossRefGoogle Scholar
Hill, J. B. (1962). Ann. N. Y. Acad. Sci. 102, 108.CrossRefGoogle Scholar
Hunt, C. E. & Harrington, D. D. (1974). Biology of the Laboratory Rabbit, ch. 16 p. 403. New York: Academic Press Inc.CrossRefGoogle Scholar
Jacob, M. & Forbes, R. M. (1970). J. Nutr. 100, 228.CrossRefGoogle Scholar
Johnson, L. C. (1966). Birth Defects: Structural Organization of the Skeleton Symposium, vol. 2, p. 66.Google Scholar
Kessler, G. & Wolfman, M. (1964). Clin. Chem. 10, 686.CrossRefGoogle Scholar
Kunkel, H. O. & Pearson, P. B. (1948 a). Archs Biochem. 18, 461.Google Scholar
Kunkel, H. O. & Pearson, P. B. (1948 b). J. Nutr. 36, 657.CrossRefGoogle Scholar
Lansing, A. I., Alex, M. & Rosenthal, T. B. (1950). J. Geront. 5, 112.CrossRefGoogle Scholar
Leblond, C. P., Wilkinson, G. W., Belanger, L. F. & Robichon, J. (1950). Am.J. Anat. 86, 289.CrossRefGoogle Scholar
Looker, T. & Berry, C. L. (1972). J. Anat. 113, 17.Google Scholar
Martin, G. R., Schiffman, E., Bladen, H. A. & Nylen, M. (1963). J. Cell Biol. 16, 243.CrossRefGoogle Scholar
Merker, H. J. & Günther, T. (1970). Z. klin. Chem. 8, 71.Google Scholar
Montgomerie, R. F., Savage, W. H. & Dodd, E. C. (1929). Vet. Rec. 9, 319.Google Scholar
Moore, L. A., Hallman, E. T. & Sholl, L. B. (1938). Archs Path. 26, 820.Google Scholar
National Research Council (1966). Publs natn. Res. Coun., Wash. no. 1194, p. 4.Google Scholar
National Research Council (1968). Publs natn. Res. Coun., Wash. no. 1599, p. 10.Google Scholar
National Research Council (1972). Publs natn. Res. Coun., Wash. no. 2028, pp. 11, 71.Google Scholar
National Research Council (1973). Publs natn. Res. Coun., Wash. no. 2045, p. 8.Google Scholar
Schiffmann, E., Martin, G. R. & Corcoran, B. A. (1964). Archs Biochem. Biophys. 107, 284.CrossRefGoogle Scholar
Smith, B. S. W. & Field, A. C. (1963). Br. J. Nutr. 17, 591.CrossRefGoogle Scholar
Smith, R. H. (1959). Biochem.J. 71, 609.CrossRefGoogle Scholar
Stowe, H. D. (1969). J. Nutr. 98, 330.CrossRefGoogle Scholar
Vaughan, J. M. (1970). The Physiology of Bone, ch. 8, p. 112. Oxford: Clarendon Press.Google Scholar
Vitale, J. J., Hellerstein, E. E., Nakamura, M. & Lown, B. (1961). Circulation Res. 9, 387.CrossRefGoogle Scholar
Walford, R. L., Carter, P. K. & Schneider, R. B. (1964). Archs Path. 78, 43.Google Scholar
Walser, M. (1967). Ergebn. Physiol. 59, 185.CrossRefGoogle Scholar
Walsh, J. J. (1974). Availability of magnesium to the equine. MSc Thesis, University of Kentucky, Lexington.Google Scholar
Walsh, J. J. & Harrington, D. D. (1973). J. Anim. Sci. 35, 206.Google Scholar
Woodward, D. L. & Reed, D. J. (1969). Am. J. Physiol. 217, 1477.CrossRefGoogle Scholar
Yu, S. Y. & Blumenthal, H. T. (1963). J. Geront. 18, 119.CrossRefGoogle Scholar