Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-27T12:39:52.408Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of ß2-adrenoceptor gene polymorphisms on diet-induced thermogenesis

Published online by Cambridge University Press:  08 March 2007

J. M. Oomen ,
P. M. C. M. Waijers ,
C. van Rossum ,
B. Hoebee ,
W. H. M. Saris  and
M. A. van Baak
J. M. Oomen*
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
P. M. C. M. Waijers
Affiliation:
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
C. van Rossum
Affiliation:
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
B. Hoebee
Affiliation:
Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
W. H. M. Saris
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
M. A. van Baak
Affiliation:
Department of Human Biology/NUTRIM, Maastricht University, Maastricht, The Netherlands
*
*Corresponding author: Dr J. M. Oomen, fax +31 (0)43 367 9776, email j.oomen@hb.unimaas.nl
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The sympathetic nervous system is involved in the control of energy metabolism and expenditure. Diet-induced thermogenesis is mediated partly by the ß-adrenergic component of this system. The aim of the present study was to investigate the role of genetic variation in the ß2-adrenoceptor in diet-induced thermogenesis. Data from twenty-four subjects (fourteen men and ten women; BMI 26·7(sem 0·8) kg/m2; age 45·2(sem1·4) years) with different polymorphisms of the ß2-adrenoceptor at codon 16 (Gly16Gly, Gly16Arg or Arg16Arg) were recruited for this study. Subjects were given a high-carbohydrate liquid meal, and the energy expenditure, respiratory exchange ratio, and plasma concentrations of NEFA, glycerol, glucose, insulin and catecholamines were measured before and over 4 h after the meal. The AUC of energy expenditure (diet-induced thermogenesis) was not significantly different between polymorphism groups, nor was the response of any of the other measured variables to the meal. In a multiple regression model, the only variable that explained a significant proportion (32 %) of the variation in diet-induced thermogenesis was the increase in plasma adrenaline in response to the meal (P<0·05). The ß2-adrenoceptor codon16 polymorphisms did not contribute significantly. In conclusion, an independent contribution of the codon 16 polymorphism of the ß2-adrenoceptor gene to the variation in thermogenic response to a high-carbohydrate meal could not be demonstrated. The interindividual variation in thermogenic response to the meal was correlated with variations in the plasma adrenaline response to the meal.

Keywords

ß2-Adrenoceptor polymorphismsDiet-induced thermogenesisCatecholamines
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 647 - 654
Copyright
Copyright © The Nutrition Society 2005

References

Alberts, G, Boomsma, F, Man in't Veld, AJ & Schalekamp, MA (1992) Simultaneous determination of catecholamines and dobutamine in human plasma and urine by high-performance liquid chromatography with fluorimetric detection. J Chromatogr 583, 236–240.CrossRefGoogle ScholarPubMed
Astrup, A, Andersen, T, Henriksen, O, Christensen, NJ, Bulow, J, Madsen, J & Quaade, F (1987) Impaired glucose-induced thermogenesis in skeletal muscle in obesity. The role of the sympathoadrenal system. Int J Obes 11, 51–66.Google ScholarPubMed
Astrup, A, Bulow, J, Christensen, NJ, Madsen, J & Quaade, F (1986) Facultative thermogenesis induced by carbohydrate: a skeletal muscle component mediated by epinephrine. Am J Physiol 250, E226–E229.Google ScholarPubMed
Astrup, A, Simonsen, L, Bulow, J, Madsen, J & Christensen, NJ (1989) Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle. Am J Physiol 257, E340–E345.Google ScholarPubMed
Bessard, T, Schutz, Y & Jequier, E (1983) Energy expenditure and postprandial thermogenesis in obese women before and after weight loss. Am J Clin Nutr 38, 680–693.CrossRefGoogle ScholarPubMed
Camastra, S, Bonora, E, Del Prato, S, Rett, K, Weck, M & Ferrannini, E (1999) Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man. EGIR (European Group for the Study of Insulin Resistance). Int J Obes Relat Metab Disord 23, 1307–1313.CrossRefGoogle ScholarPubMed
Chagnon, YC, Rankinen, T, Snyder, EE, Weisnagel, SJ, Perusse, L & Bouchard, C (2003) The human obesity gene map: the 2002 update. Obes Res 11, 313–367.CrossRefGoogle ScholarPubMed
de Jonge, L & Bray, GA (1997) The thermic effect of food and obesity: a critical review. Obes Res 5, 622–631.CrossRefGoogle ScholarPubMed
de Jonge, L & Bray, GA (2002) The thermic effect of food is reduced in obesity. Nutr Rev 60, pp. 295–297 author reply 299–300.CrossRefGoogle ScholarPubMed
Dishy, V, Sofowora, GG, Xie, HG, Kim, RB, Byrne, DW, Stein, CM & Wood, AJ (2001) The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 345, 1030–1035.CrossRefGoogle ScholarPubMed
Donahoo, WT, Levine, JA & Melanson, EL (2004) Variability in energy expenditure and its components. Curr Opin Clin Nutr Metab Care 7, 599–605.CrossRefGoogle ScholarPubMed
Echwald, SM, Sorensen, TI, Tybjaerg-Hansen, A, Andersen, T & Pedersen, O (1998) Gln27Glu variant of the human beta2-adrenoreceptor gene is not associated with early-onset obesity in Danish men. Diabetes 47, 1657–1658.CrossRefGoogle Scholar
Eriksson, P, Dahlman, I, Ryden, M, Hoffstedt, J & Arner, P (2004) Relationship between beta-2 adrenoceptor gene haplotypes and adipocyte lipolysis in women. Int J Obes Relat Metab Disord 28, 185–190.CrossRefGoogle ScholarPubMed
Garenc, C, Perusse, L & Chagnon, YC (2003) Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes Res 11, 612–618.CrossRefGoogle ScholarPubMed
Gonzalez, Sanchez JL, Proenza, AM, Martinez, Larrad MT, Ramis, JM, Fernandez, Perez C, Palou, A & Serrano, Rios M (2003) The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain. Clin Endocrinol (Oxf) 59, 476–481.CrossRefGoogle Scholar
Granata, GP & Brandon, LJ (2002) The thermic effect of food and obesity: discrepant results and methodological variations. Nutr Rev 60, 223–233.CrossRefGoogle ScholarPubMed
Harris, J & Benedict, F (1919) A Biometric Study of Basal Metabolism in Man. Washington: Carnegie Institute.Google Scholar
Hayakawa, T, Nagai, Y, Kahara, T, Yamashita, H, Takamura, T, Abe, T, Nomura, G & Kobayashi, K (2000) Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men. Metabolism 49, 1215–1218.CrossRefGoogle Scholar
Hellstrom, L, Large, V, Reynisdottir, S, Wahrenberg, H & Arner, P (1999) The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females. J Intern Med 245, 253–259.CrossRefGoogle ScholarPubMed
Hoffmann, C, Leitz, MR, Oberdorf-Maass, S, Lohse, MJ & Klotz, KN (2004) Comparative pharmacology of human beta-adrenergic receptor subtypes – characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 369, 151–159.CrossRefGoogle ScholarPubMed
Ishiyama-Shigemoto, S, Yamada, K, Yuan, X, Ichikawa, F & Nonaka, K (1999) Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia 42, 98–101.CrossRefGoogle ScholarPubMed
Kortner, B, Wolf, A, Wendt, D, Beisiegel, U & Evans, D (1999) Lack of association between a human beta-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity. Int J Obes Relat Metab Disord 23, 1099–1100.CrossRefGoogle ScholarPubMed
Large, V, Hellstrom, L, Reynisdottir, S, Lonnqvist, F, Eriksson, P, Lannfelt, L & Arner, P (1997) Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associated with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 100, 3005–3013.CrossRefGoogle ScholarPubMed
Liggett, SB (1997) Polymorphisms of the beta2-adrenergic receptor and asthma. Am J Respir Crit Care Med 156, S156–S162.CrossRefGoogle ScholarPubMed
Lowell, BB & Bachman, ES (2003) Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem 278, 29385–29388.CrossRefGoogle ScholarPubMed
Lukaski, HC, Bolonchuk, WW, Hall, CB & Siders, WA (1986) Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 60, 1327–1332.CrossRefGoogle ScholarPubMed
Matthews, DR, Hosker, JP, Rudenski, AS, Naylor, BA, Treacher, DF & Turner, RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.CrossRefGoogle ScholarPubMed
Meirhaeghe, A, Helbecque, N, Cottel, D & Amouyel, P (1999) Beta2-adrenoceptor gene polymorphism, body weight, and physical activity. Lancet 353, 896.CrossRefGoogle ScholarPubMed
Nagase, I, Yoshida, T & Saito, M (2001) Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes. FEBS Lett 494, 175–180.CrossRefGoogle ScholarPubMed
Oomen, JM, Van Rossum, CT, Hoebee, B, Saris, WH & Van Baak, MA (2005) $$$β$$$2-Adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure. J Clin Endocrinol Metab 90, 2301–230.CrossRefGoogle ScholarPubMed
Schoffelen, PF, Westerterp, KR, Saris, WH, Ten Hoor, F (1997) A dual-respiration chamber system with automated calibration. J Appl Physiol 83, 2064–2072.CrossRefGoogle ScholarPubMed
Schutz, Y, Golay, A, Felber, JP & Jequier, E (1984) Decreased glucose-induced thermogenesis after weight loss in obese subjects: apredisposing factor for relapse of obesity? Am J Clin Nutr 39, 380–387.Google ScholarPubMed
Schwartz, MW, Baskin, DG, Kaiyala, KJ & Woods, SC (1999) Model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr 69, 584–596.CrossRefGoogle ScholarPubMed
Tappy, L (1996) Thermic effect of food and sympathetic nervous system activity in humans. Reprod Nutr Dev 36, 391–397.CrossRefGoogle ScholarPubMed
Tappy, L (2004) Metabolic consequences of overfeeding in humans. Curr Opin Clin Nutr Metab Care 7, 623–628.CrossRefGoogle ScholarPubMed
Ukkola, O, Tremblay, A & Bouchard, C (2001) Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding. Int J Obes Relat Metab Disord 25, 1604–1608.CrossRefGoogle ScholarPubMed
Valensi, P, Lormeau, B, Dabbech, M, Miossec, P, Paries, J, Dauchy, F & Attali, JR (1998) Glucose-induced thermogenesis, inhibition of lipid oxidation rate and autonomic dysfunction in non-diabetic obese women. Int J Obes Relat Metab Disord 22, 494–499.CrossRefGoogle ScholarPubMed
van Marken Lichtenbelt, WD, Westerterp, KR, Wouters, L & Luijendijk, SC (1994) Validation of bioelectrical-impedance measurements as a method to estimate body-water compartments. Am J Clin Nutr 60, 159–166.CrossRefGoogle ScholarPubMed
Van Rossum, CT, Hoebee, B, Seidell, JC, Bouchard, C, Van Baak, MA, de Groot, CP, Chagnon, M, de Graaf, C & Saris, WH (2002) Genetic factors as predictors of weight gain in young adult Dutch men and women. Int J Obes Relat Metab Disord 26, 517–528.CrossRefGoogle ScholarPubMed
Weir, JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. Journal of Physiology 109, 1–9.CrossRefGoogle ScholarPubMed
Welle, S & Campbell, RG (1983a) Stimulation of thermogenesis by carbohydrate overfeeding. Evidence against sympathetic nervous system mediation. J Clin Invest 71, 916–925.CrossRefGoogle ScholarPubMed
Welle, SL & Campbell, RG (1983b) Normal thermic effect of glucose in obese women. Am J Clin Nutr 37, 87–92.CrossRefGoogle ScholarPubMed