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Intestinal absorption of sorbitol and effects of its acute administration on glucose homeostasis in normal rats

Published online by Cambridge University Press:  09 March 2007

A.-M. Lauwers ,
C. Daumerie  and
J. C. Henquin
A.-M. Lauwers
Affiliation:
Unité de Diabétologie et Nutrition, Université de Louvain, Faculté de Médecine, UCL 54.74, B–1200 Brussels, Belgium
C. Daumerie
Affiliation:
Unité de Diabétologie et Nutrition, Université de Louvain, Faculté de Médecine, UCL 54.74, B–1200 Brussels, Belgium
J. C. Henquin
Affiliation:
Unité de Diabétologie et Nutrition, Université de Louvain, Faculté de Médecine, UCL 54.74, B–1200 Brussels, Belgium
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Abstract

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1. Intestinal absorption of sorbitol was studied in a duodeno-jejunal loop of anaesthetized rats. The acute effects of exogenous sorbitol on glucose homeostasis were also evaluated in male and female rats.

2. In the presence of lumen concentrations of sorbitol ranging from l μM to 200mM, a fairly constant low percentage (about 12%) of the loop's contents was absorbed after 30 min. This amount increased only slightly with time, but this was not due to sorbitol accumulation in the mucosal layer of the loop.

3. 3-O-methylglucose was absorbed much more quickly than sorbitol, but did not interfere with sorbitol absorption. The latter was not impaired by omission of lumen sodium ions nor by phloridzin, both of which inhibited 3-O-methylglucose absorption.

4. Gastric administration of sorbitol did not affect plasma glucose or insulin levels. Glucose or sucrose administration caused a similar rise in plasma glucose, but the increase in plasma insulin levels was larger after glucose than after sucrose administration.

5. Intravenous administration of sorbitol slightly increased plasma glucose and insulin levels. These changes were, however, considerably smaller than those occurring after glucose administration.

6. In the normal rat, intestinal absorption of sorbitol is passive and proceeds at a low rate. Acute oral administration of sorbitol does not affect glucose homeostasis, which is only slightly disturbed by a large intravenous load of sorbitol.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 53 - 62
Copyright
Copyright © The Nutrition Society 1985

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