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Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects

Published online by Cambridge University Press:  09 March 2007

N. M. Delzenne ,
C. Daubioul ,
A. Neyrinck ,
M. Lasa  and
H. S. Taper
N. M. Delzenne*
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT-7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B-1200 Brussels, Belgium
C. Daubioul
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT-7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B-1200 Brussels, Belgium
A. Neyrinck
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT-7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B-1200 Brussels, Belgium
M. Lasa
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT-7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B-1200 Brussels, Belgium
H. S. Taper
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT-7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B-1200 Brussels, Belgium
*
*Corresponding author: Dr N. Delzenne, tel +32 2 764 7369, fax +32 2 764 7359, email Delzenne@pmnt.ucl.ac.be
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Abstract

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Inulin and oligofructose, besides their effect on the gastro-intestinal tract, are also able to exert ‘systemic’ effect, namely by modifying the hepatic metabolism of lipids in several animal models. Feeding male Wistar rats on a carbohydrate-rich diet containing 10 % inulin or oligofructose significantly lowers serum triacylglycerol (TAG) and phospholipid concentrations. A lower hepatic lipogenesis, through a coordinate reduction of the activity and mRNA of lipogenic enzymes is a key event in the reduction of very low-density lipoprotein-TAG secretion by oligofructose. Oligofructose is also able to counteract triglyceride metabolism disorder occurring through dietary manipulation in animals, and sometimes independently on lipogenesis modulation: oligofructose reduces post-prandial triglyceridemia by 50 % and avoids the increase in serum free cholesterol level occurring in rats fed a Western-type high fat diet. Oligofructose protects rats against liver TAG accumulation (steatosis) induced by fructose, or occurring in obese Zucker fa/fa rats. The protective effect of dietary inulin and oligofructose on steatosis in animals, would be interesting, if confirmed in humans, since steatosis is one of the most frequent liver disorders, occurring together with the plurimetabolic syndrome, in overweight people. The panel of putative mediators of the systemic effects of inulin and oligofructose consists in either modifications in glucose/insulin homeostasis, the end-products of their colonic fermentation (i.e. propionate) reaching the liver by the portal vein, incretins and/or the availability of other nutrients. The identification of the key mediators of the systemic effects of inulin and oligofructose is the key to identify target function(s) (or dysfunction(s)), and finally individuals who would take an advantage of increasing their dietary intake.

Keywords

FructansTriacylglycerolSteatosisRatShort-chain fatty acids
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S255 - S259
Copyright
Copyright © The Nutrition Society 2002

References

Brichard, S (1997) Influence de mesures nutritionnelles sur l'homéostasie glucidique du rat diabétique. Effets bénéfiques des fructo-oligosaccharides et du vanadium. PhD Thesis. Université Catholique de Louvain. Belgium.Google Scholar
Christophe, J (1998) Is there appetite after GLP-1 and PACAP? Annals of the New York Academy of Sciences 865, 323–335.CrossRefGoogle ScholarPubMed
Cortez-Pinto, H, Camilo, ME, Baptista, A, De Oliveira, AG & De Moura, MC (1999) Non-alcoholic fatty liver: another feature of the metabolic syndrome? Clinical Nutrition 18, 353–358.CrossRefGoogle ScholarPubMed
Daubioul, C, De Wispelaere, L, Taper, H & Delzenne, N (2000) Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats. Journal of Nutrition 130, 1314–1319.CrossRefGoogle Scholar
Delzenne, N & Kok, N (1998) Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism. Biochemical Society Transactions 26, 228–230.CrossRefGoogle ScholarPubMed
Delzenne, N & Kok, N (1999) Biochemical basis of oligofructose-induced hypolipidemia in animal models. Journal of Nutrition 129, 1467S–1470S.CrossRefGoogle ScholarPubMed
Delzenne, N & Williams, C (1999) Actions of non-digestible carbohydrates on blood lipids in humans and animals. In Colonic Microbiota, Nutrition and Health, pp. 213–232 [Gibson, G and Roberfroid, M, editors]. The Netherlands: Kluwer Academic Publishers.CrossRefGoogle Scholar
Delzenne, N, Kok, N, Deloyer, P & Dandrifosse, G (2000) Polyamines as mediators of physiological effects of dietary oligofructose in rats. Journal of Nutrition 130, 2456–2460.Google Scholar
Demigné, C, Morand, C, Levrat, MA, Besson, C, Moundras, C & Rémésy, C (1995) Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes. British Journal of Nutrition 74, 209–219.CrossRefGoogle ScholarPubMed
Demigné, C, Remesy, C & Morand, C (1999) Short chain fatty acids. In Colonic Microbiota, Nutrition and Health, pp. 55–70 [Gibson, G and Roberfroid, M, editors]. The Netherlands: Kluwer Academic Publishers.CrossRefGoogle Scholar
Drucker, D, Lovshin, J, Baggio, L, Nian, M, Adatia, F, Boushey, R, Liu, Y, Saleh, J, Yusta, B & Srocchi, L (2000) New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. Annals of the New York Academy of Sciences 921, 226–232.CrossRefGoogle ScholarPubMed
Fiordaliso, M-F, Kok, N, Desager, J-P, Goethals, F, Deboyser, D, Roberfroid, M & Delzenne, N (1995) Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167.CrossRefGoogle ScholarPubMed
Girard, J, Ferré, P & Foufelle, F (1997) Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annual Review of Nutrition 17, 325–352.CrossRefGoogle ScholarPubMed
Grundy, SM (2000) Metabolic complications of obesity. Endocrine 13, 155–165.CrossRefGoogle ScholarPubMed
Kok, N, Roberfroid, M, Robert, A & Delzenne, N (1996 a) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition 76, 881–890.CrossRefGoogle ScholarPubMed
Kok, N, Roberfroid, M & Delzenne, N (1996 b) Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism 45, 1547–1550.CrossRefGoogle ScholarPubMed
Kok, N, Taper, H & Delzenne, N (1998 a) Oligofructose modulates lipid metabolism alterations induced by a fat-rich diet in rats. Journal of Applied Toxicology 18, 47–53.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Kok, N, Morgan, L, Williams, C, Roberfroid, M, Thissen, JP & Delzenne, N (1998 b) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. Journal of Nutrition 128, 1099–1103.CrossRefGoogle ScholarPubMed
Koyama, K, Chen, G, Lee, Y & Unger, RH (1997) Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. American Journal of Physiology 273E, 708–713.Google Scholar
Lin, Y, Vonk, RJ & Sloof, MJ (1995) Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. British Journal of Nutrition 74, 197–207.CrossRefGoogle ScholarPubMed
Loftus, TM, Jaworsky, D, Frehywot, G, Townsend, C, Ronnett, G, Lane, M & Kuhajda, F (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379–2381.CrossRefGoogle ScholarPubMed
Luyckx, F, Lefebvre, P & Scheen, A (2000) Non alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes Metabolism 26, 98–106.Google ScholarPubMed
Manco, M, Mingrone, G, Greco, A, Capristo, E, Gniuli, D, De Gaetano, A & Gasbarrini, G (2000) Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49, 220–224.CrossRefGoogle ScholarPubMed
Marceau, P, Biron, S, Hould, F-S, Marceau, S, Simara, S, Thung, S & Kral, J (1999) Liver pathology and the metabolic syndrome X in severe obesity. Journal of Clinical Endocrinology and Metabolism 84, 1513–1517.CrossRefGoogle ScholarPubMed
Milgraum, L, Witters, L, Pasternack, G & Kuhajda, F (1997) Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clinical Cancer Research 3, 2115–2120.Google ScholarPubMed
Morand, C, Levrat, M, Bzesson, C, Demigné, C & Rémésy, C (1994) Effect of a diet rich in resistant starch on hepatic lipid metabolism in the rat. Journal of Nutritional Biochemistry 5, 138–144.CrossRefGoogle Scholar
Morgan, L (1996) The metabolic role of GIP: physiology and pathology. Biochemical Society Transactions 24, 585–591.CrossRefGoogle ScholarPubMed
Nishina, P & Freeland, R (1990) Effects of propionate on lipid biosynthesis in isolated hepatocytes. Hepatology 16, 1350–1356.Google Scholar
Oben, J, Morgan, L & Fletcher, J (1991) Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7–36)amide on fatty acid synthesis in explants of rat adipose tissue. Journal of Endocrinology 130, 267–272.CrossRefGoogle Scholar
Oku, T, Tokunaga, T & Hosoya, N (1984) Non digestibility of a new sweetener ‘Neosugar’ in the rat. Journal of Nutrition 114, 1574–1581.CrossRefGoogle Scholar
Roberfroid, M & Delzenne, N (1998) Dietary fructans. Annual Review of Nutrition 18, 117–143.CrossRefGoogle ScholarPubMed
Taskinen, MR (1993) Hyperinsulinism and dyslipidemias as coronary heart disease risk factors in NIDDM. Advances in Experimental and Medical Biology 334, 295–300.CrossRefGoogle ScholarPubMed
Takase, S, Goda, T & Watanabe, M (1994) Monostearylglycerol-starch complex: its digestibility and effects on glycemic and lipogenic responses. Journal of Nutritional Sciences and Vitaminology 40, 23–36.CrossRefGoogle ScholarPubMed
Trautwein, E, Rieckhoff, D & Eebersdobler, H (1998) Dietary inulin lowers plasma cholesterol and triacylglycerol and alters bile acid profile in hamsters. Journal of Nutrition 128, 1937–1943.CrossRefGoogle ScholarPubMed