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Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

Published online by Cambridge University Press:  09 March 2007

Yoshio Hamano ,
Sanae Sugawara ,
Yoko Kamota  and
Emi Nagai
Yoshio Hamano*
Affiliation:
Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata, Akita 010-0444, Japan
Sanae Sugawara
Affiliation:
Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata, Akita 010-0444, Japan
Yoko Kamota
Affiliation:
Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata, Akita 010-0444, Japan
Emi Nagai
Affiliation:
Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata, Akita 010-0444, Japan
*
*Corresponding author: Dr Yoshio Hamano, fax +81 185 45 2377, email yhamano@agri.akita-pu.ac.jp
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Abstract

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The present study was conducted to determine the role of α-lipoic acid (LA) in plasma metabolites, hepatic O2 consumption, and β-adrenergic response in broilers. In Expt 1, 12-d-old female broiler chicks were divided into three dietary groups and fed on diets with or without LA (5 or 50 mg/kg) until 4 or 6 weeks of age, as a 2 × 3 factorial arrangement. The dietary LA had no effect on growth rates (body weight, abdominal fat, breast muscle, and liver). The higher level of LA increased plasma non-esterified fatty acid and decreased plasma triacylglycerol concentrations only at 6 weeks of age. A 42 % increase in hepatic respiration was observed in the 4-week-old chickens given 50 mg LA/kg diet. In Expt 2, 3-d-old female broiler chicks were treated with or without dietary LA at 50 mg/kg. At 30 and 31 d old, isoproterenol (2 mg/kg body weight per h) was continuously infused into a wing vein for 2 h, and changes in plasma glucose, triacylglycerol, and non-esterified fatty acid concentrations were analysed. Isoproterenol increased plasma glucose over basal levels maximally at 60 min. Furthermore, the glucose increase in the LA-treated chickens was 35% greater than that of the controls at this time. Plasma non-esterified fatty acid and triacylglycerol concentrations were decreased by the isoproterenol infusion, regardless of LA administration. Therefore, the present study suggests that dietary LA has repartitioning effects on energy metabolism in chickens (although this depends on age-related metabolic state) and is a possible facilitator in the β-adrenergic response of plasma glucose to a β-agonist.

Keywords

Lipoic acidPlasma metabolitesβ-Adrenergic response
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 6 , December 1999 , pp. 497 - 503
Copyright
Copyright © The Nutrition Society 1999

References

Buyse, J, Decuypere, E, Huyghebaert, G & Herremans, M (1991) The effects of clenbuterol supplementation on growth performance and on plasma hormone and metabolite levels of broilers. Poultry Science 70, 993–1002.CrossRefGoogle ScholarPubMed
Cartwright, AL, Marks, HL & Campion, DR (1988) Adipose cellularity in nonselected and selected broiler stocks: measurements at equal weights and age. Poultry Science 67, 1338–1344.CrossRefGoogle Scholar
Chilliard, Y & Ottou, JF (1995) Duodenal infusion of oil in midlactation cows. 7. Interaction with niacin on responses to glucose, insulin, and β-agonist challenges. Journal of Dairy Science 78, 2452–2463.CrossRefGoogle ScholarPubMed
Christensen, K (1983) Vitamins. In Dynamic Biochemistry of Animal Production A3, pp. 215–272 [Riis, PM, editor]. Amsterdam: Elsevier Science.Google Scholar
Dalrymple, RH, Baker, PK, Gingher, PE, Engle, DL, Pensack, JM & Ricks, CA (1984) A repartitioning agent to improve performance and carcass composition of broilers. Poultry Science 63, 2376–2383.CrossRefGoogle ScholarPubMed
Goodridge, AG (1968) Lipolysis in vitro in adipose tissue from embryonic and growing chicks. American Journal of Physiology 214, 902–907.CrossRefGoogle ScholarPubMed
Gries, CL & Scott, ML (1972) The pathology of thiamin, riboflavin, pantothenic acid and niacin deficiencies in the chick. Journal of Nutrition 102, 1269–1286.CrossRefGoogle ScholarPubMed
Hamano, Y, Kobayashi, S & Terashima, Y (1994) Effects of β-adrenergic agonist (clenbuterol) on skeletal muscle protein turnover in broiler chicks fed either low or adequate protein diet. Animal Science and Technology (Japan) 65, 1105–1110.Google Scholar
Hamano, Y, Kume, K, Yamazaki, S, Kobayashi, S & Terashima, Y (1998) Combined effects of clenbuterol and various concentrations of protein on performance of broiler chickens. British Poultry Science 39, 117–122.CrossRefGoogle ScholarPubMed
Hamano, Y, Okada, S & Tanaka, T (1999) Effects of thiamine and clenbuterol on plasma metabolites and hepatic oxygen consumption in broiler chicks. British Poultry Science 40, 127–130.CrossRefGoogle ScholarPubMed
Hamano, Y, Yamazaki, S, Honma, I, Kobayashi, S & Terashima, Y (1995) Effects of β-adrenergic agonist (clenbuterol) on growth and muscle composition in broiler chicks treated with or without thyroxine. Animal Science and Technology (Japan) 66, 599–604.Google Scholar
Henriksen, EJ, Jacob, S, Streeper, RS, Fogt, DL, Hokama, JY & Tritschler, HJ (1997) Stimulation by α-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sciences 61, 805–812.CrossRefGoogle ScholarPubMed
Ivanov, VN (1974) Effect of lipoic acid on tissue respiration in rabbits with experimental atherosclerosis. Cor Vasa 16, 141–150.Google ScholarPubMed
Jacob, S, Streeper, RS, Fogt, DL, Hokama, JY, Tritschler, HJ, Dietze, GJ & Henriksen, EJ (1996) The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 45, 1024–1029.CrossRefGoogle ScholarPubMed
Khamaisi, M, Potashnik, R, Tirosh, A, Demshchak, E, Rudich, A, Tritschler, H, Wessel, K & Bashan, N (1997) Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism 46, 763–768.CrossRefGoogle ScholarPubMed
Kim, YS, Sainz, RD, Summers, RJ & Molenaar, P (1992) Cimaterol reduces β-adrenergic receptor density in rat skeletal muscles. Journal of Animal Science 70, 115–122.CrossRefGoogle ScholarPubMed
Peter, G & Borbe, HO (1995) Absorption of [7,8-14C]rac-α-lipoic acid from in situ ligated segments of the gastrointestinal tract of the rat. Drug Research 45, 293–299.Google Scholar
Reeds, PJ & Mersmann, HJ (1991) Protein and energy requirements of animals treated with β-adrenergic agonists: a discussion. Journal of Animal Science 69, 1532–1550.CrossRefGoogle ScholarPubMed
Scanes, CG, Harvey, S, Marsh, JA & King, DB (1984) Hormones and growth in poultry. Poultry Science 63, 2062–2074.CrossRefGoogle ScholarPubMed
Segermann, J, Hotze, A, Ulrich, H & Rao, GS (1991) Effect of α-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 41, 1294–1298.Google ScholarPubMed
Spence, JT & McCormick, DB (1976) Lipoic acid metabolism in the rat. Archives of Biochemistry and Biophysics 174, 13–19.CrossRefGoogle ScholarPubMed
Stiles, GL (1991) Drug and hormonal regulation of the beta-adrenergic receptor-adenylate cyclase system. In The Beta-Adrenergic Receptors, pp. 345–386 [Perkins, JP, editor]. Totowa: Humana Press.CrossRefGoogle Scholar
Streeper, RS, Henriksen, EJ, Jacob, S, Hokama, JY, Fogt, DL & Tritschler, HJ (1997) Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. American Journal of Physiology 273, E185–E191.Google ScholarPubMed
Vasilatos-Younken, R (1986) Age-related changes in tissue metabolic rates and sensitivity to insulin in the chicken. Poultry Science 65, 1391–1399.CrossRefGoogle ScholarPubMed
Wellenreiter, RH (1991) β-Adrenergic agonists for poultry. Critical Reviews in Poultry Biology 3, 229–237.Google Scholar
Weppelman, RM (1984) Effects of gonadal steroids and adrenergic agonists on avian growth and feed efficiency. Journal of Experimental Zoology 232, 461–464.CrossRefGoogle ScholarPubMed
Yang, YT & McElligott, MA (1989) Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue. Biochemical Journal 261, 1–10.CrossRefGoogle ScholarPubMed
Yoshida, M (1995) Factorial design. In Design of Experiments for Animal Husbandry pp. 125–162. Tokyo: Youkendo.Google Scholar