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Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?

Published online by Cambridge University Press:  08 March 2007

Jonathan M. Hodgson ,
Ian B. Puddey ,
Valerie Burke  and
Kevin D. Croft
Jonathan M. Hodgson*
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Ian B. Puddey
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Valerie Burke
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Kevin D. Croft
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
*
*Corresponding author: Dr Jonathan M. Hodgson, University of Western Australia, fax +61 8 9224 0246, email jonathan@cyllene.uwa.edu.au
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Abstract

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Dietary flavonoids can improve endothelial function, but the response varies between individuals. Wide variability is also seen in flavonoid O-methylation, a major pathway of flavonoid metabolism. The O-methylation of flavonoids could alter activity, and thus influence any effect on endothelial function. The objective of the current analysis was to investigate whether variability in the endothelial function response to ingestion of tea, a rich source of flavonoids, is related to the degree of O-methylation of flavonoids. This relationship was investigated in two studies in which endothelium-dependent flow-mediated dilatation (FMD) of the brachial artery was assessed and urinary 4-O-methylgallic acid (4OMGA) excretion was used as a marker of the O-methylation of tea-derived flavonoids. In the first study, amongst participants consuming five cups of tea per day for 4 weeks, the degree of increase in 4OMGA excretion was inversely associated with the change in FMD responses (r −078, p=0·008). In the second study, there was a significant difference in the FMD responses to acute ingestion of three cups of tea between individuals with a low (<median) and high (>median) 4OMGA response (1·94 (sem 0·79) % and −0·25 (sem 0·53) %, respectively; p=0·03). That is, any improvement in FMD following ingestion of tea may be enhanced in individuals who O-methylate less of the absorbed flavonoids. The present results are consistent with the suggestion that differences in flavonoid metabolism may influence their effect on endothelial function. Thus, differences in flavonoid metabolism could be related to the level of benefit of dietary flavonoids on the risk of CVD.

Keywords

FlavonoidTeaEndothelial functionMethylationCatechol-O-methyltransferase
Type
Short Communication
Information
British Journal of Nutrition , Volume 95 , Issue 1 , January 2006 , pp. 14 - 17
Copyright
Copyright © The Nutrition Society 2006

References

Caccetta, RA, Croft, KD, Beilin, LJ & Puddey, IBIngestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability Am J Clin Nutr (2000) 71 67–74CrossRefGoogle Scholar
Corretti, MC, Anderson, TJBenjamin, EJ et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force J Am Coll Cardiol (2002) 39 257–265CrossRefGoogle ScholarPubMed
Cuevas, AM, Guasch, V, Castillo, O, Irribarra, V, Mizon, C, San Martin, A, Strobel, P, Perez, D, Germain, AM & Leighton, FA highfat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids (2000) 35 143–148CrossRefGoogle ScholarPubMed
Dawling, S, Roodi, N, Mernaugh, RL, Wang, X & Parl, FFCatechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms Cancer Res, (2001) 61 6716–6722Google ScholarPubMed
Duffy, SJ, Keaney, JF JrHolbrook, M, Gokce, N, Swerdloff, PL, Frei, B & Vita, JAShort- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease Circulation (2001) 104 151–156CrossRefGoogle Scholar
Fitzpatrick, DF, Hirshfield, SL, Ricci, T, Jantzen, P & Coffey, RGEndothelium-dependent vasorelaxation caused by various plant extracts J Cardiovasc Pharmacol (1995) 26 9095CrossRefGoogle ScholarPubMed
Heiss, C, Dejam, A, Kleinbongard, P, Schewe, T, Sies, H & Kelm, MVascular effects of cocoa rich in flavan-3-ols JAMA (2003) 290 1030–1031CrossRefGoogle Scholar
Hodgson, JM, Burke, V, Beilin, LJ, Croft, KD & Puddey, IBBlack tea and plasma total homocysteine concentrations Am J Clin Nutr (2003) 77 907–911Google Scholar
Hodgson, JM, Burke, V & Puddey, IBAcute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens (2005) 23 47–54CrossRefGoogle ScholarPubMed
Hodgson, JM, Morton, LW, Puddey, IB, Beilin, LJ & Croft, KDGallic acid metabolites are markers of black tea intake in humans J Agric Food Chem (2000) 48 2276–2280CrossRefGoogle ScholarPubMed
Hodgson, JM, Puddey, IB, Burke, V, Watts, GF & Beilin, LJRegular ingestion of black tea improves brachial artery vasodilator function. Clin Sci (2002) 102 195–201CrossRefGoogle ScholarPubMed
Landmesser, UHornig, B & Drexler, HEndothelial function: a critical determinant in atherosclerosis?“ Circulation (2004) 109 II27–II33Google Scholar
Lee, MJ, Maliakal, P, Chen, L, Meng, X, Bondoc, FY, Prabhu, S, Lambert, G, Mohr, S & Yang, CSPharmacokinetics of tea catechins after ingestion of green tea and (2)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability Cancer Epidemiol Biomarkers Prev (2002) 11 1025–1032Google Scholar
Lu, H, Meng, X & Yang, CSEnzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (2)- epigallocatechin gallate. Drug Metab Disp (2003) 31 572–579Google Scholar
Nanjo, F, Goto, K, Seto, R, Suzuki, M, Sakai, M & Hara, YScavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical Free Rad Biol Med (1996) 21 895–902CrossRefGoogle Scholar
Stein, JH, Keevil, JG, Wiebe, DA, Aeschlimann, S – Folts, JDPurple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease Circulation (1999) 100 1050–1055CrossRefGoogle ScholarPubMed
Vita, JAPolyphenols and cardiovascular disease: effects on endothelial and platelet function Am J Clin Nutr (2005) 81 292S–297SCrossRefGoogle ScholarPubMed
Woodman, RJ, Playford, DA, Watts, GF et al. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J Appl Physiol (2001) 91 929–937CrossRefGoogle ScholarPubMed