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Kinetics of the appearance of cereal alkylresorcinols in pig plasma

Published online by Cambridge University Press:  08 March 2007

Anna-Maria Linko ,
Alastair B. Ross ,
Afaf Kamal-Eldin ,
Anja Serena ,
Anna Kirstin Bjørnbak Kjær ,
Henry Jørgensen ,
José L. Peñalvo ,
Herman Adlercreutz ,
Per Åman  and
Knud Erik Bach Knudsen
Anna-Maria Linko*
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Alastair B. Ross
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden Nestlé Research Centre, Lausanne 26, CH-1000, Switzerland
Afaf Kamal-Eldin
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden
Anja Serena
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
Anna Kirstin Bjørnbak Kjær
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
Henry Jørgensen
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
José L. Peñalvo
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Herman Adlercreutz
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Per Åman
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden
Knud Erik Bach Knudsen
Affiliation:
Nestlé Research Centre, Lausanne 26, CH-1000, Switzerland Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
*
*corresponding author: Dr Anna-Maria Linko, fax +358 9 191 25452, email Anna.Linko@helsinki.fi
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Abstract

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Alkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of AR-rich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5d, and arterial and venous AR concentrations were determined over 960min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120min, remained elevated between 120 and 420min, and were re-elevated on refeeding at 480min. In study 2, AR appeared in the plasma after 60min, peaked at 180–240min, and remained elevated after 960min. The apparent elimination half-life was 3·93h, and the maximum plasma concentration was 666 (sem 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.

Keywords

AlkylresorcinolsBiomarkersWholegrain cerealsRye
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 282 - 287
Copyright
Copyright © The Nutrition Society 2006

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