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Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50–65 years consuming their habitual diets

Published online by Cambridge University Press:  19 February 2008

Graham C. Burdge ,
Jonathan Powell  and
Philip C. Calder
Graham C. Burdge*
Affiliation:
Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
Jonathan Powell
Affiliation:
Unilever Research Colworth, Bedfordshire MK44 1LQ, UK
Philip C. Calder
Affiliation:
Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
*
*Corresponding author: Dr G. C. Burdge, fax +44 (0)2380 594379, email g.c.burdge@soton.ac.uk
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Abstract

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The aim of the study was to determine the effect of consuming meals with different fatty acid compositions on the postprandial changes over 6h in plasma triacylglycerol, NEFA, total cholesterol, glucose and insulin concentrations in middle-aged men and women. Men (n 11; 58 (5) years) and women (n 11; 56 (4) years) consumed four test meals with a similar macronutrient energy content in random order: a reference meal based on the habitual pattern of fatty acid intake in the UK, a meal with an increased (155%) linoleic acid (LA) to α-linolenic acid (αLNA) ratio (high LA:αLNA), a meal with increased (23%) MUFA content (high MUFA) and a meal with increased (583%) EPA and DHA content (high EPA+DHA). The high-LA:αLNA and high-EPA+DHA meals selectively increased the ratio of LA to αLNA (men 341%; women 310%) and the EPA+DHA (men 414%; women 438%) concentration in plasma triacylglycerol. The high-MUFA meal did not alter the change in MUFA content of the plasma. Plasma triacylglycerol, NEFA, glucose and insulin, but not total cholesterol, concentrations changed significantly after each meal. There was no significant effect of meal fatty acid composition or gender on maximum change in concentration, time to maximum concentration or area under the curve of any of the metabolites measured in the blood. These results suggest that differences in meal fatty acid composition exert little or no effect on postprandial changes in plasma lipids, glucose and insulin concentrations.

Keywords

Postprandial lipaemiaGenderPUFA
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 489 - 500
Copyright
Copyright © The Nutrition Society 2006

References

Bergeron, N & Havel, RJ (1996) Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. J Clin Invest 97, 65–72.CrossRefGoogle ScholarPubMed
Brown, AJ & Roberts, DC (1991) Moderate fish intake improves lipemic response to a standard fat meal. Arterioscler Thromb 11, 457–466.CrossRefGoogle ScholarPubMed
Burdge, GC & Calder, PC (2005) Plasma cytokine response during the postprandial period: a potential causal process in vascular disease? Br J Nutr 93, 3–9.CrossRefGoogle ScholarPubMed
Burdge, GC, Jones, AE, Frye, SM, Goodson, L & Wootton, SA (2003) Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men. Eur J Clin Nutr 57, 1536–1544.CrossRefGoogle ScholarPubMed
Burdge, GC, Wright, P, Jones, AE & Wootton, SA (2000) A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid phase extraction. Br J Nutr 84, 781–787.CrossRefGoogle ScholarPubMed
Cohen, JC & Schall, R (1988) Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. Am J Clin Nutr 48, 1031–1034.CrossRefGoogle ScholarPubMed
Cohn, JS, McNamara, JR, Cohn, SD, Ordovas, JM & Schaefer, EJ (1988) Postprandial plasma lipoprotein changes in human subjects of different ages. J Lipid Res 29, 469–479.CrossRefGoogle ScholarPubMed
Couillard, C, Bergeron, N, Prud'homme, D, Bergeron, J, Tremblay, A, Bouchard, C, Mauriege, P & Despres, JP (1998) Postprandial triglyceride response in visceral obesity in men. Diabetes 47, 953–960.CrossRefGoogle ScholarPubMed
de Bruin, TWABrouwer, CBvan Linde-Sibenius Trip, M, Jansen, H & Erkelens, DW (1993) Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. Am J Clin Nutr 589, 477–483.CrossRefGoogle Scholar
Demacker, PNM, Reijnen, IGM, Katan, MB, Stuyt, PMJ & Stalenhoef, AFH (1991) Increased removal of remnants of triglyceride-rich lipoproteins on a diet rich in polyunsaturated fatty acids. Eur J Clin Nutr 21, 197–203.Google Scholar
Finnegan, YE, Minihane, AM, Leigh-Firbank, EC, Kew, S, Meijer, GW, Muggli, R, Calder, PC & Williams, CM (2003) Plant-and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 77, 783–795.CrossRefGoogle ScholarPubMed
Folch, JL, Lees, M, Sloane-Stanley, GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497–509.CrossRefGoogle ScholarPubMed
Grant, KI, Marais, MP & Dhansay, MA (1994) Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance. Am J Clin Nutr 59, 853–860.CrossRefGoogle Scholar
Harris, WS & Connor, WE (1980) The effects of salmon oil upon plasma lipids, lipoproteins and triglyceride clearance. Trans Am Physiol Assoc 43, 179–184.Google Scholar
Harris, WS, Connor, WE, Alam, N & Illingworth, DR (1988) Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. J Lipid Res 299, 1451–1460.CrossRefGoogle Scholar
Harris, WS & Muzio, F (1993) Fish oil reduces postprandial triglyceride concentrations without accelerating lipid-emulsion removal rates. Am J Clin Nutr 58, 68–74.CrossRefGoogle ScholarPubMed
Harris, WS & Windsor, SL (1991) n-3 Fatty acid supplements reduce chylomicron levels in healthy volunteers. J Appl Nutr 43, 5–15.Google Scholar
Henderson, L, Gregory, J, Irving, K & Swan, G (2003) National Diet and Nutrition Survey: Adults Aged 19 to 64 Years, vol. 2, Energy, Protein, Carbohydrate, Fat and Alcohol Intake. London: The Stationery Office.Google Scholar
Jackson, KG, Wolstencroft, EJ, Bateman, PA, Yaqoob, P & Williams, CM (2005) Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: implications for insulin sensitivity and lipoprotein regulation? Br J Nutr 93, 693–700.CrossRefGoogle ScholarPubMed
Jackson, KG, Zampelas, A, Knapper, JM, Culverwell, CC, Wright, J, Gould, BJ & Williams, CM (1999) Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia. Br J Nutr 81, 51–57.CrossRefGoogle ScholarPubMed
Karpe, F (1997) Postprandial lipid metabolism in relation to coronary heart disease. Proc Nutr Soc 56, 571–678.CrossRefGoogle ScholarPubMed
Koutsari, C, Zagana, A, Tzoras, I, Sidossis, LS & Matalas, AL (2004) Gender influence on plasma triacylglycerol response to meals with different monounsaturated and saturated fatty acid content. Eur J Clin Nutr 58, 495–502.CrossRefGoogle ScholarPubMed
Lichtenstein, AH, Ausman, LM, Carrasco, W, Jenner, JL, Gualtieri, LJ, Goldin, BR, Ordovas, JM & Schaefer, EJ (1993) Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arterioscler Thromb 13, 1533–1542.CrossRefGoogle ScholarPubMed
Lovegrove, JA, Brooks, CN, Murphy, MC, Gould, BJ & Williams, CM (1997) Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. Br J Nutr 78, 223–236.CrossRefGoogle ScholarPubMed
Mann, JI, Truswell, AS & Pimstone, BL (1971) The different effects of oral sucrose and glucose on alimentary lipaemia. Clin Sci 41, 123–129.CrossRefGoogle Scholar
Nestel, PJ, Carrol, KF & Havenstein, N (1970) Plasma triglyceride response to carbohydrates, fats and caloric intake. Metabolism 19, 1–18.CrossRefGoogle ScholarPubMed
Patsch, JR (1994) Triglyceride-rich lipoproteins and atherosclerosis. Atherosclerosis 110, Suppl., S23–S26.CrossRefGoogle ScholarPubMed
Patsch, JR, Miesenbock, G, Hoferwieser, T, Muhlberger, V, Knapp, E, Dunn, JK, Gotto, Am & Patsch, W (1993) Relation of triglyceride metabolism and coronary artery disease. Arterioscler Thromb 12, 1336–1345.CrossRefGoogle Scholar
Pedersen, A, Marckmann, P & Sandstrom, B (1999) Postprandial lipoprotein, glucose and insulin responses after two consecutive meals containing rapeseed oil, sunflower oil or palm oil with or without glucose at the first meal. Br J Nutr 82, 97–104.CrossRefGoogle ScholarPubMed
Sethi, S, Gibney, MJ & Williams, CM (1993) Postprandial lipoprotein metabolism. Nutr Res Rev 6, 161–183.CrossRefGoogle ScholarPubMed
Shishehbor, F, Roche, HM & Gibney, MJ (1998) The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects. Br J Nutr 80, 411–418.CrossRefGoogle ScholarPubMed
Stampfer, MJ, Krauss, RM, Ma, J, Blanche, PJ, Holl, LG, Sacks, FM & Hennekens, CH (1996) A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA 176, 882–888.CrossRefGoogle Scholar
Swanson, JE, Laine, DC, Thomas, W & Bantle, JP (1992) Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 55, 851–886.CrossRefGoogle ScholarPubMed
van Beek, APde Ruijter-Heijstek, FC, Erkelens, DW & de Bruin, TW (1999) Menopause is associated with reduced protection from postprandial lipemia. Arterioscler Thromb Vasc Biol 19, 2737–2741.CrossRefGoogle ScholarPubMed
Weintraub, MS, Zechner, R, Brown, A, Eisenberg, S & Breslow, J (1988) Dietary polyunsaturated fats of the omega-6 and omega-3 series reduce postprandial lipoprotein levels. J Clin Invest 82, 1884–1893.CrossRefGoogle Scholar
Williams, CM (1997) Postprandial lipid metabolism: effects of dietary fatty acids. Proc Nutr Soc 56, 679–692.CrossRefGoogle ScholarPubMed
Williams, CM, Moore, F, Morgan, L & Wright, J (1992) Effects of n-3 fatty acids on postprandial triglyceride and hormone concentrations in normal subjects. Br J Nutr 68, 655–666.CrossRefGoogle ScholarPubMed
Zampelas, A, Culvenvell, CC, Knapper, JME, Jackson, K, Gould, BJ, Wright, J & Williams, CM (1994a) Olive oil and postprandial lipaemia: a study on the effect of meals of different olive oil content on postprandial lipid levels in healthy men. Proc Nutr Soc 54, 164A.Google Scholar
Zampelas, A, Knapper, JME, Jackson, KG, Culverwell, CC, Wilson, J, Gould, BJ & Williams, CM (1995) Postprandial triacylglycerol and apolipoprotein B-48 responses to meals of varying monounsaturated fatty acid content in young UK subjects. Atherosclerosis 115, S46.CrossRefGoogle Scholar
Zampelas, A, Peel, A, Gould, BJ, Wright, J & Williams, CM (1994b) Polyunsaturated fatty acids of the n-6 and n-3 series: effects on postprandial lipid and apolipoprotein levels in healthy men. Eur J Clin Nutr 48, 88–96.Google ScholarPubMed