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Long-term supplementation with selenate and selenomethionine: urinary excretion by New Zealand women

Published online by Cambridge University Press:  24 July 2007

Marion F. Robinson ,
Christine D. Thomson ,
Christopher P. Jenkinson ,
Gu Luzhen  and
Philip D Whanger
Marion F. Robinson
Affiliation:
Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand
Christine D. Thomson
Affiliation:
Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand
Christopher P. Jenkinson
Affiliation:
Mental Retardation Research Center, Center for Health Science, 760 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90024-1759., USA
Gu Luzhen
Affiliation:
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, 29 Nan Wei Road, Beijing, People's Republic of China
Philip D Whanger
Affiliation:
4Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon 97331 -6502, USA
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Abstract

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Thirty-six New Zealand women aged between 18 and 23 years received daily for 32 weeks, 200 µg Se as Se-enriched yeast (selenomethionine, SeMet), or brewer's yeast mixed with selenate, or no added Se (placebo) in a double-blind trial. Mean daily Se excretion increased with both supplements; the selenate group excreted more than the SeMet group, 123 v. 66 µg/d respectively at week 2, equivalent to 57 v. 27 % of the dose. Thereafter Se output increased for the SeMet group reaching a plateau at about 100 µg/d at week 16, when plasma Se had also plateaued at 190 ng/ml. The selenate group had reached an earlier plateau of 110 ng Se/ml at week 7. There was a close relationship between 24 h urine and plasma Se for the SeMet group but not for the selenate group. Renal plasma clearances showed two distinctly different responses; the clearance of 0·4 ml/min reached by the SeMet group at week 2 plateaued as plasma Se increased almost 2-fold; whereas for the selenate group the clearance varied between 0·8 and 1·1 ml/min whilst plasma Se remained almost constant at 110 ng/ml. Previous studies, also of 200 µgSe/d as Se-rich bread, in New Zealand (NZ) and elsewhere showed similar responses to Se-yeast; the selenite response was intermediate between selenate and Se-yeast (SeMet). The full significance of these studies awaits identification of Se components in plasma, glomerular filtrate and urine; meanwhile renal clearances serve as a pointer to changes in the distribution of Se-containing fractions in the plasma. Trimethylselenonium was detected in basal urines, and was a minor component in urines of supplemented NZ subjects at about 1 % of the total Se.

Keywords

SeleniumUrinary excretionRenal plasma clearanceWomen
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 4 , April 1997 , pp. 551 - 563
Copyright
Copyright © The Nutrition Society 1997

References

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