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Metabolism of ε-(γ-L-glutamyl)-L-lysine in the rat

Published online by Cambridge University Press:  09 March 2007

G. Raczyński ,
M. Snochowski  and
S. Buraczewski
G. Raczyński
Affiliation:
Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, near Warsaw, Poland
M. Snochowski
Affiliation:
Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, near Warsaw, Poland
S. Buraczewski
Affiliation:
Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, near Warsaw, Poland
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Abstract

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1. A study was made of the metabolism of ɛ-(γ-L-glutamyl)-L[4, 5-3H]lysine (GL) in the rat.

2. The compound was largely absorbed from the intestine and metabolized. Labelled lysine was incorporated into blood proteins.

3. In an in vitro experiment with everted sacs of rat small intestine, GL passed through the intestinal wall unchanged.

4. The results of comparative tests using homogenates of different body tissues indicated that the kidneys were particularly active in hydrolysing GL. Their activity was nine times greater than that of the liver and eighteen times greater than that of the small intestine.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 34 , Issue 2 , September 1975 , pp. 291 - 296
Copyright
Copyright © The Nutrition Society 1975

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