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No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man

Published online by Cambridge University Press:  09 March 2007

S. J. Long ,
J. A. Sutton ,
W. B. Amaee ,
A. Giouvanoudi ,
N. M. Spyrou ,
P. J. Rogers  and
L. M. Morgan
S. J. Long
Affiliation:
School of Biological Sciences University of Surrey, Guildford, GU2 5XH, UK
J. A. Sutton
Affiliation:
Guildford Clinical Pharmacology Unit Royal Surrey County Hospital, Guildford, GU2 5XX, UK
W. B. Amaee
Affiliation:
Department of Physics University of Surrey, Guildford, GU2 5XH, UK
A. Giouvanoudi
Affiliation:
Department of Physics University of Surrey, Guildford, GU2 5XH, UK
N. M. Spyrou
Affiliation:
Department of Physics University of Surrey, Guildford, GU2 5XH, UK
P. J. Rogers
Affiliation:
Institute of Food Research Reading Laboratory, Reading RG6 2EF, UK
L. M. Morgan*
Affiliation:
School of Biological Sciences University of Surrey, Guildford, GU2 5XH, UK
*
*Corresponding author:Dr Linda M. Morgan, fax +44 (0)1483 576978, email L.Morgan@surrey.ac.uk
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Abstract

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Centrally administered glucagon-like peptide-1 (GLP-1) inhibits feeding in fasted rats, but its role in human satiety has been largely unexplored. The present study investigated the effect of peripheral GLP-1 infusion on gastric emptying and satiety in man. Ten non-obese male subjects were infused in a randomized single-blind within-subject crossover study using saline infusion as control. They received either a GLP-1 infusion (1·2 pmol/kg per min) or a saline infusion for 1 h, at 18.00 hours. At 20 min after starting the infusion the gastric emptying of a 400 ml water load was measured. Subjects completed behavioural self-rating scales to assess hunger and satiety. After 40 min subjects were given a buffet meal ad libitum and their food intake was recorded. GLP-1 infusion raised circulating GLP-1 concentrations to approximately twice those seen following a meal. It did not affect circulating insulin levels but caused a small fall in glucose levels. Gastric emptying of the water load was significantly delayed by the GLP-1 infusion. Energy intake from the buffet was unaffected by GLP-1 infusion. Self-assessment of hunger and satiety was similarly unaffected by the infusion before the buffet meal, although subjects tended to be less hungry after the buffet meal following GLP-1 infusion (P < 0·09). GLP-1 infusion delayed gastric emptying but had a minimal effect on food intake and satiety. This study casts doubts on whether GLP-1 is a major satiety factor in man, although a raised circulating plasma glucose level, as would normally occur postprandially, might be necessary for GLP-1 to increase satiety.

Keywords

Glucagon-like peptide-1Food intakeSatietyGastric emptying
Type
Research Article
Information
British Journal of Nutrition , Volume 81 , Issue 4 , April 1999 , pp. 273 - 279
Copyright
Copyright © The Nutrition Society 1999

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