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Phyto-oestrogen levels in foods: the design and construction of the VENUS database

Published online by Cambridge University Press:  26 October 2011

Mairead Kiely ,
Marian Faughnan ,
Kristiina Wähälä ,
Henny Brants  and
Angela Mulligan
Mairead Kiely*
Affiliation:
Nutritional Sciences, Department of Food Science, Food Technology and Nutrition, University College Cork, Ireland
Marian Faughnan
Affiliation:
School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
Kristiina Wähälä
Affiliation:
Department of Chemistry, Laboratory of Organic Chemistry, PO Box 55, FIN-00014, University of Helsinki, Finland
Henny Brants
Affiliation:
TNO Nutrition and Food Research, Department of Nutritional Epidemiology, PO Box 360, 3700 AJ Zeist, The Netherlands
Angela Mulligan
Affiliation:
Department of Public Health and Primary Care, University of Cambridge, and MRC Dunn Human Nutrition Unit, Cambridge CB2 2XY, UK
*
*Corresponding author: Dr M. Kiely, fax +353 21 4270244, email m.kiely@ucc.ie
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The objective of the Vegetal Estrogens in Nutrition and the Skeleton (VENUS) project was to evaluate existing data on dietary exposure to compounds with oestrogenic and anti-oestrogenic effects present in plant foods as constituents or contaminants, and to identify and disseminate in vitro and in vivo methodologies to analyse the effects of such compounds on bone. To permit the assessment of exposure to isoflavones in European populations (Italy, the UK, Ireland, The Netherlands), the VENUS database of phyto-oestrogen levels in foods was established. Data on the isoflavone (genistein and daidzein) content of 791 foods, including almost 300 foods commonly consumed in Europe, were collected. Levels of coumestrol, formononetin and biochanin A in a limited number of foods were also included. Lignan levels (secoisolariciresinol and matairesinol) in 158 foods were incorporated into the database, which also contains information on the references sourced for the compositional data, on the analytical methods used by each author and on the number of foods analysed in each reference. The VENUS database was constructed in Microsoft® Access 2000, which is widely available as part of Microsoft® Office Professional. This paper outlines the procedures used for the selection and evaluation of existing literature data for incorporation into the database. In addition, the design of the database is described, along with the data entry and quality control procedures used in its construction. Limitations of the data are discussed and guidelines for its use are provided.

Keywords

IsoflavonesFood composition dataLignans
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue S1: Effects of Phyto-oestrogens on Bone Health: the VENUS Concerted Action , June 2003 , pp. S19 - S23
Copyright
Copyright © The Nutrition Society 2003

References

Adlercreutz, H (1995) Phyto-oestrogens: epidemiology and a possible role in cancer protection. Environmental Health Perspectives 103, 103–112.Google Scholar
Allred, CD, Allred, KF, Ju, YH, Virant, SM & Helferich, WG (2001) Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumours in a dosedependent manner. Cancer Research 61, 5045–8050.Google Scholar
Araujo, JMA, Santos, CJC & Moriera, MA (1995) Isoflavones content in soybean cultivars. Arqives Biology Tecnology 38, 725–730.Google Scholar
Barnes, S (2003) Phyto-oestrogens and osteoporosis: what is a safe dose? British Journal of Nutrition 89, Suppl. 1, S101–S108.Google Scholar
Choi, J-S, Kwon, T-W & Kim, J-S (1996) Isoflavone contents in some varieties of soybean. Foods and Biotechnology 5, 167–169.Google Scholar
Coward, L, Barnes, NC, Setchell, KDR & Barnes, S (1993) Genistein, daidzein and their (β-glucoside conjugates: antitumour isoflavones in soybean foods from American and Asian diets. Journal of Agriculture and Food Chemistry 41, 1961–1967.Google Scholar
Coward, L, Kirk, M, Albin, N & Barnes, S (1996) Analysis of plasma isoflavones by reversed-phase HPLC–multiple reaction ion monitoring-mass spectrometry. Clinica Chimica Acta 247, 121–142.CrossRefGoogle ScholarPubMed
De Kleijn, MJJvan der Schouw, YT, Wilson, PWFAdlercreutz, H, Mazur, W, Grobbee, DE & Jacques, PF (2001) Intake of dietary phyto-oestrogens is low in postmenopausal women in the United States: The Framingham Study. Journal of Nutrition 131, 1826–1832.CrossRefGoogle ScholarPubMed
Dwyer, AT, Goldin, BR, Saul, N, Gualteri, A, Barakat, S & Adlercreutz, H (1994) Tofu and soy drinks contain phyto-oestrogens. Journal of the American Dietetic Association 94, 739–743.CrossRefGoogle Scholar
Elakovich, SD & Hampton, JM (1984) Analysis of coumestrol, a phyto-oestrogen, in alfalfa tablets sold for human consumption. Journal of Agriculture and Food Chemistry 32, 173–175.CrossRefGoogle ScholarPubMed
Eldridge, AC (1982) Determination of isoflavones in soybean flours, protein concentrates and isolates. Journal of Agriculture and Food Chemistry 30, 353–355.CrossRefGoogle Scholar
Eldridge, AC & Kwolek, WF (1983) Soybean isoflavones: effect of environment and variety on composition. Journal of Agriculture and Food Chemistry 31, 394–396.Google Scholar
Franke, AA, Custer, LJ, Cerna, CM & Narala, K (1995) Rapid HPLC analysis of dietary phyto-oestrogens from legumes and from human urine. Proceedings of the Society for Experimental Biology and Medicine 208, 18–26.Google Scholar
Franke, AA, Custer, LJ, Wang, W & Shi, CY (1998) HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids. Proceedings of the Society for Experimental Biology and Medicine 217, 263–273.CrossRefGoogle ScholarPubMed
Franke, AA, Hankin, JH, Yu, MC, Maskarinee, G, Low, S-H & Custer, LJ (1999) Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. Journal of Agriculture and Food Chemistry 47, 977–986.CrossRefGoogle ScholarPubMed
Fukutake, M, Takahashi, M, Ishida, K, Kawamura, H, Sugimura, T & Wakabayashi, K (1996) Quantification of genistein and genistin in soybeans and soybean products. Food and Chemical Toxicology 34, 457–461.Google Scholar
Holland, B, Welch, AA, Unwin, ID, Buss, DH, Paul, AA & Southgate, DAT (1995) McCance & Widdowson's The Composition of Foods Fifth Edition. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food. London: HMSO.Google Scholar
Horn-Ross, PL, John, EM, Lee, M, Stewart, SL, Koo, J, Sakoda, LC, Shiau, AC, Goldstein, J, Davis, P & Perez-Stable, EJ (2001) Phyto-oestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. American Journal of Epidemiology 154, 434–441.Google Scholar
Jones, AE, Price, KR & Fenwick, GR (1989) Development and application of a HPLC method for the analysis of phyto-oestrogens. Journal of Science Food and Agriculture 46, 357–364.CrossRefGoogle Scholar
Liggins, J, Bluck, LJ, Runswick, S, Atkinson, C, Coward, WA & Bingham, SA (2000 a) Daidzein and geni stein contents of vegetables. British Journal of Nutrition 84, 717–725.Google Scholar
Liggins, J, Bluck, LJ, Runswick, S, Atkinson, C, Coward, WA & Bingham, SA (2000 b) Daidzein and genistein content of fruits and nuts. Journal of Nutritional Biochemistry 11, 326–331.Google Scholar
Mazur, W (1998) Phyto-oestrogen content in foods. Baillière's Clinical Endocrinology and Metabolism 12, 729–743.CrossRefGoogle ScholarPubMed
Mazur, W & Adlercreutz, H (2000) Overview of naturally occurring endocrine-active substances in the human diet in relation to human health. Nutrition 16, 654–687.Google Scholar
Mazur, WM, Duke, JA, Wahala, K, Rasku, S & Adlercreutz, H (1998) Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. Journal of Nutritional Biochemistry 9, 193–200.Google Scholar
Mazur, W, Fotsis, T, Wähälä, K, Ojala, S, Salakka, A & Adlercreutz, H (1996) Isotope dilution gas chromatographic–mass spectrometric method for the determination of isoflavonoids, coumestrol and lignans in food samples. Analytical Biochemistry 233, 169–180.Google Scholar
Mazur, WM, Wähälä, K, Rasku, S, Salakka, A, Hase, T & Adlercreutz, H (1998) Lignan and isoflavonoid concentrations in tea and coffee. British Journal of Nutrition 79, 37–45.Google Scholar
Mei, J, Yeung, SS & Kung, AW (2001) High dietary phyto-oestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. Journal of Clinical Endocrinology and Metabolism 86, 5217–5221.CrossRefGoogle Scholar
Morton, M, Arisaka, O, Miyake, A & Evans, B (1999) Analysis of phyto-oestrogens by gas chromatography–mass spectrometry. Environmental Toxicology and Pharmacology 7, 221–225.Google Scholar
Mullner, C & Sontag, G (1999) Determination of some phyto-oestrogens in soybeans and their processed products with HPLC and coulometric electrode array detection. Fresenius Journal of Analytical Chemistry 364, 261–265.Google Scholar
Murphy, PA (1982) Phyto-oestrogen content of processed soybean products. Food Technology January, 60–64.Google Scholar
Murphy, PA, Song, T, Buseman, G & Barua, K (1997) Isoflavones in soy-based infant formulas. Journal of Agriculture and Food Chemistry 45, 4635–4638.CrossRefGoogle Scholar
Murphy, PA, Song, T, Buseman, G, Barua, K, Beecher, GR, Trainer, D & Holden, J (1999) Isoflavones in retail and institutional soy foods. Journal of Agriculture and Food Chemistry 47, 2697–2704.Google Scholar
Nguyenle, T, Wang, E & Cheung, AP (1995) An investigation on the extraction and concentration of isoflavones in soy-based products. Journal of Pharmaceutical and Biomedical Analysis 14, 221–232.Google Scholar
Padgette, SR, Taylor, NB, Nida, DL, Bailey, MR, MacDonald, J, Holden, LR & Fuchs, RL (1996) The composition of glyphosate-tolerant soybean seeds is equivalent to that of conventional soybeans. Journal of Nutrition 126, 702–716.Google Scholar
Pettersson, H & Kiessling, K-H (1984) Liquid chromatographic determination of the plant oestrogens coumestrol and isoflavones in animal feed. Journal of the Official Association of Analytical Chemists 67, 503–506.Google Scholar
Riboli, E & Norat, T (2001) Cancer prevention and diet: opportunities in Europe. Public Health Nutrition 4, 475–484.CrossRefGoogle ScholarPubMed
Sirtori, CR (2001) Risks and benefits of soy phyto-oestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Safety 24, 665–682.Google Scholar
Valtueña, S, Cashman, K, Robins, SP, Cassidy, A, Kardinaal, A & Branca, F (2003) Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women. British Journal of Nutrition 89, Suppl. 1, S87–S99.Google Scholar
Van Erp-Baart, AMJBrants, HAMKiely, M, Mulligan, A, Turrini, A, Sermoneta, C, Kilkkinen, A & Valsta, LM (2001) Isoflavone intake in different European countries: the Vegetal Estrogens in Nutrition and the Skeleton approach. Annals of Nutrition and Metabolism 45, 217–234 Abstr.Google Scholar
Van Erp-Baart, AMJBrants, HAMKiely, M, Mulligan, A, Turrini, A, Sermoneta, C, Kilkkinen, A & Valsta, LM (2003) Isoflavone intake in four different European countries: the Vegetal Estrogens in Nutrition and the Skeleton approach. British Journal of Nutrition 89, Suppl. 1, S25–S30.Google Scholar
Wakai, K, Egami, I, Kato, K, Kawamura, T, Tamakoshi, A, Lin, Y, Nakayama, T, Wada, M & Ohno, Y (1999) Dietary intake and sources of isoflavones among Japanese. Nutrition and Cancer 33, 139–145.CrossRefGoogle ScholarPubMed
Wang, G, Kuan, SS, Francis, OJ, Ware, GM & Carman, AS (1990) A simplified HPLC method for the determination of phyto-oestrogens in soybean and its processed products. Journal of Agriculture and Food Chemistry 38, 185–190.CrossRefGoogle Scholar
Wang, H-J & Murphy, PA (1994 a) Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year and location. Journal of Agriculture and Food Chemistry 42, 1674–1677.CrossRefGoogle Scholar
Wang, H-J & Murphy, PA (1994 b) Isoflavone content in commercial soybean foods. Journal of Agriculture and Food Chemistry 42, 1666–1673.Google Scholar
Wang, H-J & Murphy, PA (1996) Mass balance study of isoflavones during soybean processing. Journal of Agriculture and Food Chemistry 44, 2377–2383.Google Scholar
Xu, X, Wang, H-J, Murphy, PA, Cook, L & Hendrich, S (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. Journal of Nutrition 124, 825–832.CrossRefGoogle ScholarPubMed