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Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?

Published online by Cambridge University Press:  08 March 2007

Graham C. Burdge  and
Philip C. Calder
Graham C. Burdge*
Affiliation:
Institute of Human Nutrition, Developmental Origins of Adult Health and Disease Division, Biomedical Sciences Building (62), University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
Philip C. Calder
Affiliation:
Institute of Human Nutrition, Developmental Origins of Adult Health and Disease Division, Biomedical Sciences Building (62), University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
*
*Corresponding author: Dr G. C. Burdge, fax +44 2380 594379, email g.c.burdge@soton.ac.uk
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Abstract

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Chronic inflammation of the vascular endothelium produces endothelial dysfunction and ultimately atherogenesis. Postprandial hyperlipidaemia is an independent risk factor for cardiovascular disease. Recent studies show that the magnitude of postprandial lipaemia following a single fatty meal is negatively related to vascular function. This is associated with a transient increase in the concentrations of pro-inflammatory cytokines and soluble adhesion molecules and in pro-oxidant activity. One possible interpretation is that repeated exposure of the blood vessel wall to the activities of pro-inflammatory cytokines and pro-oxidants may damage the vascular endothelium and promote atherogenesis. Based on these results, we propose a model of a causal mechanism to explain how consumption of a fatty meal may impair vascular dysfunction.

Keywords

Vascular dysfunctioncytokinespostprandialcardiovascular disease
Type
Horizons in nutritional science
Information
British Journal of Nutrition , Volume 93 , Issue 1 , January 2005 , pp. 3 - 9
Copyright
Copyright © The Nutrition Society 2005

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