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Rats treated with oleoyl-oestrone maintain glucidic homeostasis: comparisons with a pair-fed model

Published online by Cambridge University Press:  08 March 2007

Anna Salas ,
Montserrat Esteve ,
M. Mar Grasa  and
Xavier Remesar
Anna Salas
Affiliation:
Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain
Montserrat Esteve
Affiliation:
Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain
M. Mar Grasa
Affiliation:
Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain
Xavier Remesar*
Affiliation:
Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain
*
*Corresponding author: Prof. Dr Xavier Remesar, fax +34 93 403 70 64, email xremesar@ub.edu
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Abstract

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To determine whether or not the weight (and fat) loss induced by oleoyl-oestrone treatment results only as a consequence of decreased food intake, we compared treated animals with a pair-fed model. To this end, Wistar female rats received daily oral gavages of 10μmol/kg per d oleoyl-oestrone in sunflower oil, or vehicle alone for 10 or 20d. A second group of rats received the gavage of sunflower oil and the same amount of food ingested as the oleoyl-oestrone-treated animals (pair-fed group). Rats treated with oleoyl-oestrone maintained glucidic metabolism homeostasis despite a marked decrease in adipose tissue weight (P<0·001). Pair-fed rats exhibited a different pattern, comparable to short-term starvation, with greatly decreased glycogen stores (P<0·0001). The most significant effects were detected in the 10d period groups. Oleoyl-oestrone affected the activity of the ponderostat system not only by decreasing appetite but also by modifying energy partition: treated animals maintained their glucose and energy homeostasis despite decreased food intake and the massive depletion of lipid stores.

Keywords

Oleoyl-oestroneBody weightPair-fed
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 738 - 745
Copyright
Copyright © The Nutrition Society 2005

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