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Relationships between micronutrient intake and biochemical indicators of nutrient adequacy in a ‘free-living’ elderly UK population

Published online by Cambridge University Press:  09 March 2007

Angela L. Bailey ,
Susan Maisey ,
Susan Southon ,
Anthony J. A. Wright ,
Paul M. Finglas  and
Robert A. Fulcher
Angela L. Bailey
Affiliation:
Institute of Food Research, Nonvich Research Park, Colney, Nonvich NR4 7UA
Susan Maisey
Affiliation:
Department of Medicine for the Elderly, West Nonvich Hospital, Nonvich NR2 3TU
Susan Southon
Affiliation:
Institute of Food Research, Nonvich Research Park, Colney, Nonvich NR4 7UA
Anthony J. A. Wright
Affiliation:
Institute of Food Research, Nonvich Research Park, Colney, Nonvich NR4 7UA
Paul M. Finglas
Affiliation:
Institute of Food Research, Nonvich Research Park, Colney, Nonvich NR4 7UA
Robert A. Fulcher
Affiliation:
Department of Medicine for the Elderly, West Nonvich Hospital, Nonvich NR2 3TU
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Abstract

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Nutritional assessments are frequently based on amounts of nutrients consumed. In the present paper the usefulness of nutrient intake data for assessing nutrient adequacy is examined in an elderly British population. Subjects were ‘free-living’ elderly aged 68-90 years (sixty men, eighty-five women) in Norwich. Forty-two of forty-nine surviving males and sixty-seven of seventy-nine surviving females were reassessed after 2 years. With few exceptions, estimated micronutrient intake was not statistically predictive of biochemical measures of nutrient adequacy. Initial biochemical measures of nutritional adequacy were compared with those found 2 years later in an attempt to assess whether initial biochemical assessment was predictive of the ‘longer term’situation. Biochemical measurements at the start of the study were correlated to the same measurements made 2 years later for: serum ferritin, haemoglobin and erythrocyte count, whole-blood Se-glutathione peroxidase (EC 1.11.1.9; males only), plasma Cu, alkaline phosphatase (EC 3.1.3.1), ascorbic acid, vitamin B6 (pyridoxal-5-phosphate), folate and vitamin B12, total erythrocyte thiamin (males only), riboflavin (erythrocyte glutathione reductase (EC 1.6.4.1) activation coefficient): but not for: erythrocyte Cu-superoxide dismutase (EC 1.15.1.1) or plasma Zn. Either only small changes, or no changes, in mean values were seen over the 2 years for most of the biochemical measures. One exception was a large increase in plasma folate. The only important ‘negative’ features seen at 2-year follow up were a large fall in serum ferritin concentration and a large increase in the activity of two antioxidant defence enzymes, superoxide dismutase and glutathione peroxidase. As judged by currently accepted biochemical deficiency threshold values, asmall proportion of subjects were possibly at risk of Fe (3% men; 1% women), folate (7%, 3%), thiamin (12%;3%) and vitamin C (15%; 17%) deficiency. Many more appeared to be at risk of vitamin B6 (42%; 47%) and riboflavin (77%; 79%) deficiency. It was concluded that the requirements of the elderly for vitamins B1, B2 and C, and the biochemical deficiency threshold vahes used to indicate vitamin B6 deficiency, need review

Keywords

MicronutrientsDietary surveyNutrient statusElderly
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 2 , February 1997 , pp. 225 - 242
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Albert, M. J., Mathan, V. I. & Baker, S. J. (1980). Vitamin B12 synthesis by human small intestinal bacteria. Nature 283,781–782.CrossRefGoogle ScholarPubMed
Altman, D. G. (1991). Practical Statisticsfor Medical Research, p. 303. London: Chapman and Hall.Google Scholar
Bailey, A. L. & Finglas, P. M. (1990). A normal phase high performance liquid chromatographic method for determination of thiamin in blood and tissue samples. Journal of Micronutrient Analysis 7, 147–157.Google Scholar
Bailey, A. L., Finglas, P. M., Wright, A. J. A. & Southon, S. (1994). Thiamin intake, erythrocyte transketolase activity and total erythrocyte thiamin in adolescents. British Journal of Nutrition 72, 111–115.CrossRefGoogle ScholarPubMed
Bailey, A. L., Southon, S., Wright, A. J. A., Finglas, P. M. & Maisey, S. (1994 b). High performance liquid chromatographic determination of plasma pyridoxal-5-phosphate by use of the cyanide derivative. Proceedings of the Nutrition Society 53, 134A.Google Scholar
Behrens, W. A. & Madere, R. (1987). A highly sensitive HPLC method for the estimation of ascorbic and dehydro-ascorbic acid in tissues, biological fluids and foods. Analytical Biochemistry 165, 102–107.CrossRefGoogle Scholar
Black, A. E., Goldberg, G. R., Jebb, S. A., Livingstone, M. B. E., Cole, T. J. & Prentice, A. M. (1991). Critical evaluation of energy intake data using fundamental principles of energyphysiology. 2. Evaluating the results of published surveys. European Jouml of Clinical Nutrition 45, 583–599.Google ScholarPubMed
Borschel, M. W., Kirksey, A. & Hamaker, B. R. (1987). A micromethod for determination of plasma pyridoxal phosphate and its use in assessment of storage stability of the vitamer. Journal of Pediatric Gastroenterology and Nutrition 6, 409–413.Google ScholarPubMed
Ceballos-Picot, I., Nicole, A. & Sinet, P. M. (1992). Cellular clones and transgenic mice overexpressing copper-zinc superoxide dismutase: models for the study of free radical metabolism and ageing. EXS 62, 89–98.Google Scholar
Crawley, H. (1988). Food Portion Sizes. London: H.M. Stationery Office.Google Scholar
Department of Health (1991). Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.Google Scholar
Department of Health (1992). The Nutrition of Elderly People. Report on Health and Social Subjects no. 43. London: H.M. Stationery Office.Google Scholar
Finglas, P. M., Bailey, A., Walker, A., Loughridge, J. M., Wright, A. J. A. & Southon, S. (1993). Vitamin C intake and plasma ascorbic acid concentration in adolescents. British Journal of Nutrition 69, 563–576.CrossRefGoogle ScholarPubMed
Finglas, P. M., Wright, A. J. A., Faulks, R. M. & Southgate, D. A. T. (1990). Revised folate content of UK vegetables - implications for intake. In Recent Knowledge on Iron and Folate Dejciencies in the World.Colloque INSERM no. 197, pp. 385–392 [Hercberg, S., Galan, P. and Dupin, H., editors]. Paris: INSERM.Google Scholar
Gibson, R. S. (1990). Principles of Nutritional Assessment. Oxford: Oxford University Press.Google Scholar
Goldberg, G. R., Black, A. E., Jebb, S. A., Cole, T. J., Murgatroyd, P. R., Coward, W. A. & Prentice, A. M.(1991). Critical evaluation of energy intake data using fundamental principles of energy physiology. 1.Derivation of cut-off limits to identify under-recording. European Journal of Clinical Nutrition 45,569–581.Google Scholar
Hazell, T. (1985). Copper and zinc. World Review of Nutrition and Dietetics 46, 67–80.Google Scholar
Holland, B., Unwin, I. D. & Buss, D. H. (1988). Cereals and Cereal Products. The 3rd Supplement to McCance and Widdowson'The Composition of Foods. Cambridge: Royal Society of Chemistry/MAFFGoogle Scholar
Holland, B., Unwin, I. D. & Buss, D. H. (1989). Milk Products and Eggs. The 4th Supplementto McCance and Widdowson' The Compostion of Foods. Combridge: Royal Society of Chemistry\MAFF.Google Scholar
Lentner, C. (1984 a). Alkaline phosphatase. In Geigy Scientific Tables, vol. 3, pp. 186–187. Basle: Ciba-Geigy Ltd.Google Scholar
Lentner, C. (1984 b). Blood-inorganic substances. In Geigy Scientifc Tables, vol.3, pp. 78–89. Basle: Ciba-Geigy Ltd.Google Scholar
Lentner, C. (1984 c). Blood-vitamins. In Geigy Scientific Tables, vol. 3, pp. 125–134. Basle: Ciba-Geigy Ltd.Google Scholar
Maisey, S., Loughridge, J. M., Southon, S. & Fulcher, R. (1995). Variation in food group and nutrient intake with day of the week in an elderly population. British Journal of Nutrition 73, 359–373.CrossRefGoogle Scholar
Manore, M. M., Vaughan, L. A., Carroll, S. S. & Lecklem, J. E. (1989). Plasma pyridoxal 5'-phosphate concentration and dietary vitamin B6 intake in free-living, low-income elderly people. American Journal of Clinical Nutrition 50, 339–345.CrossRefGoogle ScholarPubMed
Mertz, W. (1992). Trace elements and ageing. In Nutrition of the Elderly. NestléNutrition Workshop Series, vol.29, pp. 145–149. [Munro, H. and Schlierf, G., editors]. New York: Raven Press.Google Scholar
Naoi, M., Ichinose, H., Takahashi, T. & Nagatsu, T. (1988). Sensitive assay for the determination of pyridoxal-5-phosphate in enzymes using high performance liquid chromatography afterderivatization with cyanide. Journal of Chromatography 434,209–214.CrossRefGoogle ScholarPubMed
Paglia, D. E. & Valentine, W. N. (1967). Studies on the quantitative and qualitative characteristics of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70, 158–169.Google Scholar
Paul, A. A. & Southgate, D. A. T. (1978). McCance and Widdowson's The Composition of Foods, 4th ed. London: H.M. Stationery Office.Google Scholar
Payette, H. & Gray-Donald, K. (1991). Dietary intake and biochemical indices of nutritional status in an elderly population, with estimates of the precision of the 7-d food record. American Journal of Clinical Nutrition 54,478–488.CrossRefGoogle Scholar
Powers, H. J., Bates, C. J., Prentice, A. M., Lamb, W. H., Jepson, M. & Bowman, H. (1993). The relative effectiveness of iron and iron with riboflavin in correcting microcytic anaemia in men and children in rural Gambia. Human Nurition:Clinical Nurition 37C, 413–425.Google Scholar
Rose, C. S., György, P., Butler, M., Andres, R., Noms, A. H., Shock, N. W., Tobin, J., Brin, M. & Spiegel, H.(1976). Age differences in vitamin B6 status of 617 men. American Journal of Clinical Nutrition 29,847–853.CrossRefGoogle ScholarPubMed
Russell, R. M. (1992). Micronutrient requirements of the elderly. Nutrition Reviews 50, 463–466.CrossRefGoogle ScholarPubMed
Schofield, W. N. (1985). Predicting basal metabolic rate, new standards and reviews of previous work. Human Nutrition: Clinical Nutrition 39C, Suppl. 1, 5–41.Google Scholar
Southon, S., Wright, A. J. A., Finglas, P. M., Bailey, A. L. & Belsten, J. L. (1992). Micronutrient intake and psychological performance of schoolchildren: considerations of the value of calculated nutrient intakes for the assessment of micronutrient status in children. Proceedings of the Nutrition Society 51, 315–324.CrossRefGoogle ScholarPubMed
Southon, S., Wright, A. J. A., Finglas, P. M., Bailey, A. L., Loughridge, J. M. & Walker, A. D. (1994). Dietary intake and micronutrient status of adolescents: effect of vitamin and trace element supplementation on indices of status and performance in tests of verbal and non-verbal intelligence. British Journal of Nutrition 71, 897–918.CrossRefGoogle ScholarPubMed
Tan, S. P., Wenlock, R. W. & Buss, D. H. (1985). Immigrant Foods. The 2nd Supplement to McCance and Widdowson's The Composition of Foods. London: H.M. Stationery Office.Google Scholar
Wanger, P. D., Beilstein, M. A., Thomson, C. D., Robinson, M. F. & Howe, M. (1988). Blood selenium and glutathione peroxidase activity of populations in New Zealand, Oregon and South Dakota. FASEB Journal 2, 2996–3002.CrossRefGoogle Scholar
Wiles, S. J., Nettleton, P. A., Black, A. E. & Paul, A. A. (1980). The nutrient composition of some dishes eaten in Britain: a supplementary food composition table. Journal of Human Nutrition 34, 189–223.Google Scholar
Wright, A. J. A., Southon, S., Bailey, A. L., Finglas, P. A., Maisey, S. & Fulcher, R. A. (1995). Nutrient intake and biochemical status on non-institutionalized elderly subjects in Norwich comparison with younger adults and adolescents from the same general community. British Journal of Nutrition 74, 453–475.CrossRefGoogle ScholarPubMed