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Replacement of linoleic acid with α-linolenic acid does not alter blood lipids in normolipidaemic men

Published online by Cambridge University Press:  09 March 2007

D. Pang ,
M. A. Allman-Farinelli ,
T. Wong ,
R. Barnes  and
K. M. Kingham
D. Pang
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
M. A. Allman-Farinelli*
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
T. Wong
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
R. Barnes
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
K. M. Kingham
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
*
*Corresponding author: Dr M. A. Allman-Farinelli, fax +61 2 9351 6022, email m.allman@biochem.usyd.edu.au
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Abstract

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The effect of partial dietary replacement of linoleic acid (18:2n-6; linoleic acid-rich diet) with α-linolenic acid (18:3n-3; α-linolenic acid-rich diet) on plasma lipids was investigated in twenty-nine healthy young men. After a 2-week stabilization period subjects were randomly assigned to either the α-linolenic acid-rich diet group (n 15), receiving a mean of 10.1 g of α-linolenic acid and 12.1 g of linoleic acid/d, or the linoleic acid-rich diet group (n 14), receiving a mean of 1.0 g of α-linolenic acid and 21.0 g of linoleic acid/d, for a 6-week test period. Blood samples were taken at the commencement of the stabilization period and at the start (week 0), midpoint (week 3) and endpoint (week 6) of the test period and plasma lipids analysed. The changes occurring on the linoleic acid-rich diet and α-linolenic acid-rich diet were compared but no significant differences in the changes in plasma total cholesterol, LDL-cholesterol, HDL-cholesterol, the subfractions HDL2 and HDL3 or triacylglycerols were found. These results indicate that dietary replacement of linoleic acid with α-linolenic acid in the diet of healthy male subjects offers similar cardioprotective benefits with respect to lipid metabolism.

Keywords

Linolenic acidLinoleic acidBlood lipidsLinseed oil
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 2 , February 1998 , pp. 163 - 167
Copyright
Copyright © The Nutrition Society 1998

References

Bang, HO & Dyerberg, J (1972) Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Medica Scandinavica 192, 85–94.CrossRefGoogle ScholarPubMed
Bang, HO, Dyerberg, J & Hjørne, N (1976) The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavica 200, 69–73.Google Scholar
Becker, N, Illingworth, DR, Alaupovic, P, Connor, WE & Sundberg, EE (1983) Effects of saturated, monounsaturated, and ω-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in humans. American Journal of Clinical Nutrition 37, 355–360.CrossRefGoogle ScholarPubMed
Bonanome, A & Grundy, SM (1988) Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. New England Journal of Medicine 318, 1244–1248.CrossRefGoogle ScholarPubMed
Criqui, MH, Heiss, G, Cohn, R, Cowan, LD, Suchindran, CM, Bangdiwala, S, Kritchevsky, S, Jacobs, DR Jr, O'Grady, HK & Davis, CE (1993) Plasma triglyceride level and mortality from coronary heart disease. New England Journal of Medicine 328, 1220–1225.Google Scholar
de Logeril, M, Renaud, S, Mamelle, N, Salen, P, Martin, JL, Monjaud, I, Guidollet, J, Taboul, P & Delaye, J (1994) Mediterrenean α-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343, 1454–1459.CrossRefGoogle Scholar
Dyerberg, J, Bang, HO & Hjørne, N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. American Journal of Clinical Nutrition 28, 958–966.CrossRefGoogle ScholarPubMed
Folch, J, Lees, M & Sloane-Stanley, G (1957) A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge. Clinical Chemistry 18, 449–502.CrossRefGoogle ScholarPubMed
Grundy, SM & Vega, GL (1988) Plasma cholesterol responsiveness to saturated fatty acids. American Journal of Clinical Nutrition 47, 822–824.Google Scholar
Harris, WS (1997) n-3 Fatty acids and serum lipoproteins; human studies. American Journal of Clinical Nutrition 65, 1645S–1654S.Google Scholar
Harris, WS, Connor, WE, Alam, N & Illingworth, DR (1988) Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, 1451–1460.CrossRefGoogle ScholarPubMed
Hegsted, DN, McGandy, RB, Myers, SM & Stare, FJ (1965) Quantitative effects of dietary fat on blood cholesterol in man. American Journal of Clinical Nutrition 14, 776–787.Google Scholar
Kelley, DS, Nelson, GJ, Love, JE, Branch, LB, Taylor, PC, Schmidt, PC, Mackey, BE & Iacono, JM (1993) Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533–537.CrossRefGoogle ScholarPubMed
Kestin, M, Clifton, P, Belling, GB & Nestel, PJ (1990) n-3 Fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. American Journal of Clinical Nutrition 51, 1028–1034.Google Scholar
Kromhout, D, Bosschieter, EB, Drijver, M & de Lezenne, Coulander C (1988) Serum cholesterol and 25-year incidence of and mortality from myocardial infarction and cancer. The Zutphen Study. Archives of Internal Medicine 148, 1051–1055.CrossRefGoogle ScholarPubMed
Lepage, G & Roy, CC (1986) Direct transesterification of all classes of lipids in a one-step reaction. Journal of Lipid Research 27, 114–120.CrossRefGoogle Scholar
Lewis, J, Holt, R & English, R (1992) Composition of Foods Australia: 6. Canberra: Australian Government Publishing Service.Google Scholar
McDonald, BE, Gerrard, JM, Bruce, VM & Corner, EJ (1989) Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. American Journal of Clinical Nutrition 50, 1382–1388.CrossRefGoogle ScholarPubMed
Mantzioris, E, James, MJ, Gibson, RA & Cleland, LG (1994) Dietary substitution with an α-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. American Journal of Clinical Nutrition 59, 1304–1309.CrossRefGoogle ScholarPubMed
National Institute of Health Consensus Conference (1993) Triglyceride, high-density lipoprotein, and coronary heart disease. Journal of the American Medical Association 269, 505–510.Google Scholar
Pekkanen, J, Linn, S, Heiss, G, Suchindran, CM, Leon, A, Rifkind, BM & Tyroler, HA (1990) Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. New England Journal of Medicine 332, 1700–1707.CrossRefGoogle Scholar
Rose, G & Shipley, M (1986) Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study. British Medical Journal 293, 306–307.Google Scholar
Rustan, AC, Nossen, JØ, Christiansen, EN & Drevon, CA (1988) Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase. Journal of Lipid Research 29, 1417–1426.CrossRefGoogle Scholar
Salonen, JT, Salonen, R, Seppänen, K, Rauramaa, R & Tuomilehto, J (1991) HDL, HDL2, and HDL3 subfractions, and the risk of acute myocardial infarction. Circulation 84, 129–139.CrossRefGoogle ScholarPubMed
Sanders, TAB & Roshanai, F (1983) The influence of different types of ω3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clinical Science 64, 91–99.CrossRefGoogle Scholar
Sanders, TAB, Vickers, M & Haines, AP (1981) Effect of blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clinical Science 61, 317–324.CrossRefGoogle Scholar
Singer, P, Wirth, M & Berger, I (1990) A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. Atherosclerosis 83, 167–175.CrossRefGoogle ScholarPubMed
Truswell, AS, Craske, JD, English, R, Nestel, PJ, Sinclair, A, Lester, IH & Lilburne, A (1992) The Role of Polyunsaturated Fats in the Australian Diet. Report of the National Health and Medical Research Council Working Party. Canberra: Australian Government Publishing Service.Google Scholar
Valsta, LM, Jauhiainen, M, Aro, A, Salminen, I & Mutanen, M (1995) The effects on serum lipoprotein levels of two monounsaturated fat rich diets differing in their linoleic and α-linolenic acid contents. Nutrition and Metabolism in Cardiovascular Disease 5, 129–140.Google Scholar
von Schacky, C, Fischer, S & Weber, PC (1985) Long-term effects of dietary marine ω-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. Journal of Clinical Investigation 76, 1626–1631.Google Scholar
Wardlaw, GM, Snook, JT, Lin, MC, Puangco, MA & Kwon, JS (1991) Serum lipid and apolipoprotein concentrations in healthy men on diets enriched with either canola oil or safflower oil. American Journal of Clinical Nutrition 54, 104–110.CrossRefGoogle ScholarPubMed
Warnick, GR, Benderson, J & Albers, JJ (1982) Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry 28, 1379–1388.CrossRefGoogle ScholarPubMed
Zucker, ML, Bilyeu, DS, Helmkamp, GM, Harris, WS & Dujovne, CA (1988) Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. Atherosclerosis 73, 13–22.CrossRefGoogle ScholarPubMed