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Selenium supplementation affects the retention of stable isotopes of selenium in human subjects consuming diets low in selenium

Published online by Cambridge University Press:  09 March 2007

John W. Finley ,
Anna Duffield ,
Pengcheng Ha ,
Richard A. Vanderpool  and
Christine D. Thomson
John W. Finley*
Affiliation:
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202,USA†
Anna Duffield
Affiliation:
Department of Human Nutrition, University of Otago, Dunedin, New Zealand
Pengcheng Ha
Affiliation:
Centre for Indigenous Peoples' Nutrition and Environment, McGill University, Ste-Anne-de-Bellevue, Quebec, H9X 3V9, Canada
Richard A. Vanderpool
Affiliation:
PO Box 3006,State UniversityArkansas 72467,USA
Christine D. Thomson
Affiliation:
Department of Human Nutrition, University of Otago, Dunedin, New Zealand
*
*Corresponding author: Dr J. W. Finley, fax +1 701 795 8395, email jfinley@gfhnrc.ars.usda.gov
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Abstract

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Twenty-nine women and fifteen men from an area of low Se intake (South Island of New Zealand) consumed 100 μg stable 74Se, as selenate given in water after an overnight fast, and blood was collected for 3 weeks. They were then divided into five groups and supplemented with 0, 10, 20, 30 and 40 μg Se/d (as selenomethionine) for 5 months. After 5 months, they received a second dose of 74Se identical to the first. Supplementation significantly altered retention of 74Se in the plasma, but not in the erythrocytes or platelets. Subjects receiving the placebo retained the greatest amount, and subjects receiving 30 μg supplemental Se/d retained the least 74Se. Supplementation resulted in relatively more isotope being retained in a medium molecular mass protein considered to be albumin, and relatively less in another fraction considered to be selenoprotein P. The lack of many observed changes in retention of stable Se, and the shift in retention among the plasma proteins, suggests that supplemental Se was not being used to replete critical pools of Se, probably because of adaptation to low Se intake.

Keywords

SeleniumStable isotopes
Type
Short communication
Information
British Journal of Nutrition , Volume 82 , Issue 5 , November 1999 , pp. 357 - 360
Copyright
Copyright © The Nutrition Society 1999

References

Buckley, W, Budac, J, Godfrey, D & Koenig, K (1992) Determination of selenium by inductively coupled plasma mass spectrometry utilizing a new hydride generation sample introduction system. Analytical Chemistry 64, 724–729.CrossRefGoogle ScholarPubMed
Chen, X, Yang, G, Wen, Z, Chen, J & Ge, K (1981) Relation of selenium deficiency to the occurrence of Keshan disease. In Selenium in Biology and Medicine, pp. 171–175 [Spallholz, J, Martin, J and Ganther, H, editors]. New York, NY: Van Nostrand Reinhold Co.Google Scholar
Clark, J, Combs, G, Turnbull, B, Slate, E, Chalker, D, Chow, J, Davis, L, Glover, R, Graham, G, Gross, E, Krongard, A, Lesher, J, Park, H, Sanders, B, Smith, C & Taylor, J (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. Journal of the American Medical Association 276, 1957–1963.CrossRefGoogle ScholarPubMed
Finley, J (1999) The retention and distribution by healthy young men of stable isotopes of selenium consumed as selenite, selenate or hydroponically-grown broccoli are dependent on the isotopic form. Journal of Nutrition 129, 854–871.CrossRefGoogle ScholarPubMed
Finley, J & Penland, J (1996) Adequacy or deprivation of dietary selenium in healthy men: Clinical and psychological findings. Journal of Trace Elements in Experimental Medicine 11, 11–27.3.0.CO;2-6>CrossRefGoogle Scholar
Finley, J, Vanderpool, R & Korynta, E (1995) Use of stable isotopic selenium as a tracer to follow incorporation of selenium into selenoproteins. Proceedings of the Society for Experimental Biology and Medicine 210, 270–277.CrossRefGoogle ScholarPubMed
Gilbertson, L & King, G (1950) Crystalline selenic acid. Inorganic Synthesis 3, 137–140.CrossRefGoogle Scholar
Kasper, L, Young, V & Janghorbani, M (1984) Short-term dietary selenium restriction in young adults: Quantitative studies with the stable isotope 74SeO3. British Journal of Nutrition 52, 443–455.CrossRefGoogle ScholarPubMed
Kleinbaum, D & Kupper, L (1978) Applied Regression Analysis and Other Multivariable Methods. North Scituate, MA: Duxbury Press.Google Scholar
National Research Council (1989) Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy Press.Google Scholar
Robinson, M (1988) McCollum award lecture. The New Zealand selenium experience. American Journal of Clinical Nutrition 48, 521–534.CrossRefGoogle ScholarPubMed
Robinson, M (1989) Selenium in human nutrition in New Zealand. Nutrition Research 47, 99–107.Google ScholarPubMed
Thomson, C & Robinson, M (1986) Urinary and fecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite. American Journal of Clinical Nutrition 44, 659–663.CrossRefGoogle ScholarPubMed
Thomson, C & Robinson, M (1996) The changing selenium status of New Zealand residents. European Journal of Clinical Nutrition 50, 107–114.Google ScholarPubMed
Van Rij, A, Thomson, CD, McKenzie, J & Robinson, M (1979) Selenium deficiency in total parenteral nutrition. American Journal of Clinical Nutrition 32, 2076–2085.CrossRefGoogle ScholarPubMed
Yang, J, Hill, KE & Burk, R (1989) Dietary selenium intake controls rat plasma selenoprotein P concentration. Journal of Nutrition 119, 1010–1012.CrossRefGoogle ScholarPubMed