Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-26T05:44:02.867Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum selenium determinants in French adults: the SU.VI.M.AX study

Published online by Cambridge University Press:  08 March 2007

J. Arnaud ,
S. Bertrais ,
A. M. Roussel ,
N. Arnault ,
D. Ruffieux ,
A. Favier ,
S. Berthelin ,
C. Estaquio ,
P. Galan  and
S. Czernichow
...Show all authors
J. Arnaud*
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France Nutrition, Vieillissement et Maladies Cardiovasculaires, Université Joseph Fourier, Faculté de Pharmacie, Domaine de la Merci, 38700 La Tronche, France
S. Bertrais
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
A. M. Roussel
Affiliation:
Nutrition, Vieillissement et Maladies Cardiovasculaires, Université Joseph Fourier, Faculté de Pharmacie, Domaine de la Merci, 38700 La Tronche, France
N. Arnault
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
D. Ruffieux
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France
A. Favier
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France
S. Berthelin
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France
C. Estaquio
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
P. Galan
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
S. Czernichow
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
S. Hercberg
Affiliation:
U557 Inserm (UMR Inserm-Inra-Cnam), Institut Scientifique et Technique de la Nutrition et de l'Alimentation, 5 rue Vertbois, 75003 Paris, France
*
*Corresponding author: fax +33 4 76 76 58 21, email JArnaud@chu-grenoble.fr
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The objective of the present work was to assess the relationship between serum Se concentrations and environmental determinants (i.e. lifestyle, social activity, geographic region, urban status, education, familial status, physical activity, BMI, tobacco, and food and alcohol consumption). Baseline results from 13017 subjects (7876 women aged 35–60 and 5141 men aged 45–60) who participated in the SU.VI.M.AX (Supplémentation en Vitamines et Minéraux Antioxydants) study were analysed. Fewer than 2% of the volunteers had a serum Se status under 0·75μmol/l, which has been quoted as the cut-off of biological Se sub-deficiency. Women had significantly lower serum Se concentrations than men (1·09 (sd 0·19) μmol/l (n 7423) and 1·14 (sd 0·20) μmol/l (n 4915), P<0·0001, respectively). Significant differences in serum Se concentrations were observed between geographic areas. In both sexes, the serum Se concentration increased with alcohol, meat and fish consumption, and decreased with smoking. In premenopausal women, the serum Se concentration was higher in contraceptive-pill users than in non-users. In women only, age was associated with increased serum Se concentrations, and obesity (BMI≥30kg/m2) was associated with decreased serum Se levels. In men, we observed a decrease in serum Se concentrations with increased consumption of vegetables and fruits. In conclusion, though few of the volunteers participating in the SU.VI.M.AX study had Se status in the sub-deficiency range, 83% of women and 75% of men had serum concentrations below the value considered optimal for glutathione peroxidase activity. The largest Se associations in both sexes were found with regions, smoking, alcohol, meat and fish consumption. Further studies are needed to understand the difference in Se status between genders.

Keywords

Selenium in serumSelenium determinantsHuman nutritionLifestyle
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 313 - 320
Copyright
Copyright © The Nutrition Society 2006

References

Alfthan, G&Néve, JReference values for serum selenium in various areas evaluated according to the TRACY protocol. J Trace Elem Med Biol 1996 10 77–87CrossRefGoogle Scholar
Arnaud, J&Preziosi, PRéponse du zinc et du sélénium sériques au supplément vitaminique et minéral antioxydant chez des volontaires sains. L'Eurobiologiste 1994 28 161–165Google Scholar
Arnaud, JPrual, APreziosi, PFavier, A&Hercberg, SSelenium determination in human milk in Niger: influence of maternal status. J Trace Elem Electrolytes Health Dis 1993 7 199–204Google ScholarPubMed
Backovic, DMarinkovic, JJorga, JPavlica, MMaksimovic, Z&Nikolic, MEnvironmental factors, health-related habits, and serum selenium levels in cancer patients and healthy controls. Biol Trace Elem Res 1999 67 55–62CrossRefGoogle ScholarPubMed
Bergmann, SNeumeister, VSiekmeier, RMix, CWahrburg, U&aJaross, WFood supply abundant increase of serum selenium concentrations in middle-aged Dresden women between 1990–1996. DRECAN-team. Dresden cardiovascular risk and nutrition. Toxicol Lett 1998 96/97 181–187CrossRefGoogle Scholar
Berr, CCognitive impairment and oxidative stress in the elderly: results of epidemiological studies. Biofactors 2000 13 205–209CrossRefGoogle ScholarPubMed
Berr, CCoudray, CBonithon-Kopp, CRoussel, AMMainard, F&Alperovitch, ADemographic and cardiovascular risk factors in relation to antioxidant status; the EVA study. Int J Vitam Nutr Res 1998 68 26–35Google ScholarPubMed
Borawska, MHWitkowska, AMHukalowicz, K&Markiewicz, RInfluence of dietary habits on serum selenium concentration Ann Nutr Metab 2004 48 134–140CrossRefGoogle ScholarPubMed
Bradley, KABadrinath, SBush, KBoyd-Wickizer, J&Anawalt, BMedical risks for women who drink alcohol. J Gen Intern Med 1998 13 627–639CrossRefGoogle ScholarPubMed
Broome, CSMcArdle, FKyle, JAMAndrews, FLowe, NMHart, CAArthur, JR&Jackson, MJAn increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status Am J Clin Nutr 2004 80 154–162CrossRefGoogle ScholarPubMed
Bugel, SHSandstrom, B&Larsen, EHAbsorption and retention of selenium from shrimps in man J Trace Elem Med Biol 2001 14 198–204CrossRefGoogle ScholarPubMed
Bugel, SSandstrom, B&Skibsted, LHPork meat: a good source of selenium? J Trace Elem Med Biol 2004 17 307–311CrossRefGoogle ScholarPubMed
Bureau, IAnderson, RArnaud, JRaysiguier, YFavier, A&Roussel, AMTrace mineral status in post menopausal women: impact of hormonal replacement therapy J Trace Elem Med Biol 2002 16 9–13CrossRefGoogle ScholarPubMed
Combs, GFSelenium in global food systems. Br J Nutr 2001 85 517–547CrossRefGoogle ScholarPubMed
de Lorimier, AAAlcohol, wine, and health Am J Surg 2000 180 357–361CrossRefGoogle ScholarPubMed
Djujic, ISJozanov-Stankov, ONMilovac, MJankovic, V&Djermanovic, VBioavailability and possible benefits of wheat intake naturally enriched with selenium and its products. Biol Trace Elem Res 2000 77 273–285CrossRefGoogle ScholarPubMed
Dubois, FTeby, ABelleville, FNabet, P&Paysant, PValeurs usuelles du sélénium sérique dans une population de l'est de la France (Common values of serum selenium in a population in Eastern France). Ann Biol Clin 1990 48 28–32Google Scholar
Fenster, CPWeinsier, RLDarley-Usmar, VM&Patel, RPObesity, aerobic exercise, and vascular disease: the role of oxidant stress Obes Res 2002 10 964–968CrossRefGoogle ScholarPubMed
Finley, JWGrusak, MAKeck, AS&Gregoire, BRBioavailability of selenium from meat and broccoli as determined by retention and distribution of 75Se Biol Trace Elem Res 2004 99 191–209CrossRefGoogle ScholarPubMed
Golubkina, NA & Alfthan, GVThe human selenium status in 27 regions of Russia. J Trace Elem Med Biol 1999 13 15–20CrossRefGoogle ScholarPubMed
Hagmar, LPersson-Moschos, MAkesson, B&Schutz, APlasma levels of selenium, selenoprotein P and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on Latvian fish consumers. Eur J Clin Nutr 1998 52 796–800CrossRefGoogle Scholar
Hansen, JCDeutch, B&Pedersen, HSSelenium status inn Greenland Inuit. Sci Tot Environ 2004 331 207–214CrossRefGoogle Scholar
Hercberg, SGalan, PPreziosi, PBertrais, SMennen, LMalvy, DRoussel, AMFavier, A&Briancon, SThe SU.VI.M.AX study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004 164 2335–2342CrossRefGoogle Scholar
Hercberg, SPreziosi, PBriançon, SGalan, PPaul-Dauphin, AMalvy, DRoussel, AM&Favier, AA primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.M.AX study design, methods, and participant characteristics. SUpplementation en VItamines et Mineraux AntioXydants. Control Clin Trials 1998 19 336–351CrossRefGoogle Scholar
Hines, LM&Rimm, EBModerate alcohol consumption andn coronary heart disease: a review. Postgrad Med J 2001 77 747–752CrossRefGoogle Scholar
Hughes, KChoo, MKuperan, POng, CN&Aw, TCCardiovascular risk factors in relation to cigarette smoking: a population-based survey among Asians in Singapore Atherosclerosis 1998 137 253–258CrossRefGoogle ScholarPubMed
Kafai, MR&Ganji, VSex, age, geographical location, smoking, and alcohol consumption influence serum selenium concentrations in the USA: third national health and nutrition examination survey, 1988–1994 J Trace Elem Med Biol 2003 17 13–18CrossRefGoogle ScholarPubMed
Keaney, JFLarson, MGVasan, RSWilson, PWFLipinska, ICorey, DMassaro, JMSutherland, PVita, JA&Benjamin, EJObesity and systemic oxidative stress. Clinical correlates of oxidative stress in the Framingham study Arterioscler Thromb Vasc Biol 2003 23 434–439CrossRefGoogle ScholarPubMed
Kilander, LBerglund, LBoberg, MVessby, B &Lithell, HEducation, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men. Int J Epidemiol 2001 30 1119–1126CrossRefGoogle Scholar
Kosatsky, TPrzybysz, R&Armstrong, B2000) Mercury exposure in Montrealers who eat St Lawrence river sportfish Environ Res 2000 84 36–43CrossRefGoogle ScholarPubMed
Koyama, HWatanabe, CSatoh, HHosokai, H&Tamura, SConsistent relationship between selenium and apolipoprotein A-II concentrations in the sera of fasting middle-aged male abstainers and regular consumers of alcohol. Biol Trace Elem Res 1995 50 33–42CrossRefGoogle ScholarPubMed
Lamand, MTressol, JC&Bellanger, JThe mineral and trace element composition in French food items and intake levels in France. J Trace Elem Electrolytes Health Dis 1994 8 195–202Google ScholarPubMed
Lamand, MTressol, JCIreland-Ripert, JFavier, JC&Feinberg, MParis: Technique et Documentation, INRA Répertoire général des aliments. 1996Google Scholar
Le Jeannic, T&Vidalenc, JParis: INSEE Premiére Pöles urbains et péyriurbanisation – Le zonage en aires urbaines. 1997 516Google Scholar
Le Moullec, NDeheeger, MPreziosi, PMontero, PValeix, PRolland-Cachera, MFPotier de Courcy, GChristides, JPGalan, P &Hercberg, SValidation du manuel-photos utilisé pour l'enquéte alimentaire de l'tude SU.VI.M.AX. Cah Nutr Diet 1996 31 158–164Google Scholar
Luoma, PAntioxidants, infections and environmental factors in health and disease in northern Finland. Int J Circumpolar Health 1998 57 109–113Google ScholarPubMed
Meltzer, HMBibow, KPaulsen, ITMundal, HHNorheim, G & Holm, HDifferent bioavailability in humans of wheat and fish selenium as measured by blood platelet response to increased dietary Se. Biol Trace Elem Res 1993 36 229–241CrossRefGoogle Scholar
Meltzer, HMNorheim, GLoken, EB& Holm, HSupplementation with wheat selenium induces a dose-dependent response in serum and urine of a Se-replete population Br J Nutr 1992 67 287–294CrossRefGoogle ScholarPubMed
Néve, JNew approaches to assess selenium status and requirement Nutr Rev 2000 58 363–369CrossRefGoogle ScholarPubMed
Niskar, ASPaschal, DCKieszak, SMFlegal, KMBowman, BGunter, EWPirkle, JLRubin, CSampson, EJ& McGeehin, MSerum selenium levels in the US population. Biol Trace Elem 2003 91 1–10CrossRefGoogle ScholarPubMed
Patrick, LSelenium biochemistry and cancer: a review of the literature Altern Med Rev 2004 9 239–258Google Scholar
Pavao, MLCordeiro, CCosta, ARaposo, JASantos, MCNéve, J & Viegas-Crespo, AMComparison of whole blood glutathione peroxidase activity, levels of serum selenium, and lipid peroxidation in subjects from the fishing and rural communities of ‘Rabo de Peixe’ village, San Miguel island, The Azores archipelago, Portugal Biol Trace Elem Res 2003 92 27–40CrossRefGoogle Scholar
Pincemail, JLecomte, JCastiau, JPCollard, EVasankari, TCheramy-Bien, JPLimet, R&Defraigne, JOEvaluation of autoantibodies against oxidized LDL and antioxidant status in top soccer and basketball players after 4 months of competition. Free Rad Biol Med 2000 28 559–565CrossRefGoogle ScholarPubMed
Rayman, MPDietary selenium: time to act. Br Med J 1997 314 387–388CrossRefGoogle ScholarPubMed
Rayman, MPThe argument for increasing selenium intake. Proc Nutr Soc 2002 61 203–215CrossRefGoogle ScholarPubMed
Robberecht, H&Deelstra, HFactors influencing blood selenium concentration values: a literature review. J Trace Elem Electrolytes Health Dis 1994 8 129–143Google ScholarPubMed
Shi, B&Spallholz, JESelenium from beef is highly bioavailable as assessed by liver glutathione peroxidase (EC 1.11.1.9) activity and tissue selenium Br J Nutr 1994 72 873–881CrossRefGoogle ScholarPubMed
Simonoff, M, Conri, C, Fleury, B, Berdeu, B, Moretto, P, Ducloux, G, Llabador, YSerum and erythrocyte selenium in normal and pathological states in France. Trace Elem Med 1988 5 64–69.Google Scholar
Simonoff, M,Simonoff, GLe sélénium et la vie. ParisMasson 1991Google Scholar
Smith, AM, Chang, MPH, Medeiros, LCGenerational differences in selenium status of women. Biol Trace Elem Res 2000 75 157–165.CrossRefGoogle ScholarPubMed
Snook, JT, Palmquist, DL, Moxon, AL, Cantor, AH, Vivian, VMSelenium status of a rural (predominantly Amish) community living in a low-selenium area. Am J Clin Nutr 1983 38 620–630.CrossRefGoogle Scholar
Telisman, S, Jurasovic, J, Pizent, A, Cvitkovic, PBlood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals. Environ Res 2001 87 57–68.CrossRefGoogle ScholarPubMed
Tessier, F, Margaritis, I, Richard, MJ, Moynot, C, Marconnet, PSelenium and training effects on the glutathione system and aerobic performance. Med Sci Sports Exerc 1995 27 390–396.CrossRefGoogle ScholarPubMed
Thomson, CDAssessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr 2004 58 391–402.CrossRefGoogle ScholarPubMed
Thorling, EB, Overvad, K, Geboers, JSelenium status in Europe – human data. A multicenter study. Ann Clin Res 1986 18 3–7.Google ScholarPubMed
Thorngren, M, Akesson, BEffect of dietary fish on plasma selenium and its relation to haemostatic changes in healthy adults. Int J Vit Nutr Res 1987 57 429–435.Google ScholarPubMed
Van Dael, P, Deelstra, HSelenium. Int J Vit Nutr Res 1993 63 312–316.Google ScholarPubMed
Verlinden, M, Van Sprundel, M, Van der Auwera, JC, Eylenbosch, WJThe selenium status of Belgian population groups. 1.Healthy adults. Biol Trace Elem Res 1983 5 91–102.CrossRefGoogle Scholar
Zhang, X, Shi, B, Spallholz, JEhe selenium content of selected meats, seafoods, and vegetables form Lubbock, Texas. Biol Trace Elem Res 1993 39 161–169.CrossRefGoogle Scholar