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Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women

Published online by Cambridge University Press:  08 March 2007

J. Hallund ,
S. Bügel ,
T. Tholstrup ,
M. Ferrari ,
D. Talbot ,
W. L. Hall ,
M. Reimann ,
C.M. Williams  and
N. Wiinberg
J. Hallund*
Affiliation:
Department of Human NutritionCentre for Advanced Food StudiesThe Royal Veterinary and Agricultural UniversityFrederiksbergDenmark
S. Bügel
Affiliation:
Department of Human NutritionCentre for Advanced Food StudiesThe Royal Veterinary and Agricultural UniversityFrederiksbergDenmark
T. Tholstrup
Affiliation:
Department of Human NutritionCentre for Advanced Food StudiesThe Royal Veterinary and Agricultural UniversityFrederiksbergDenmark
M. Ferrari
Affiliation:
Human Nutrition UnitNational Institute for Research on Food and NutritionRomeItaly
D. Talbot
Affiliation:
Unilever R&DColworthSharnbrookBedfordshireUK
W. L. Hall
Affiliation:
Hugh Sinclair Unit of Human NutritionSchool of Food BiosciencesUniversity of ReadingReadingUK
M. Reimann
Affiliation:
Dietary Fibre and the Metabolic Syndrome GroupGerman Institute of Human NutritionPotsdam-RehbrueckeNuthetalGermany
C.M. Williams
Affiliation:
Hugh Sinclair Unit of Human NutritionSchool of Food BiosciencesUniversity of ReadingReadingUK
N. Wiinberg
Affiliation:
Department of Clinical Physiology and Nuclear MedicineFrederiksberg University HospitalFrederiksbergDenmark
*
*Corresponding author: Dr J. Hallund, fax +45 35282483, email jeha@kvl.dk
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Abstract

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Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.

Keywords

Phyto-oestrogensPostmenopausal womenEndothelial functionArterial compliance
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 6 , June 2006 , pp. 1120 - 1126
Copyright
Copyright © The Nutrition Society 2006

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