Hostname: page-component-745bb68f8f-kw2vx Total loading time: 0 Render date: 2025-01-26T06:14:55.389Z Has data issue: false hasContentIssue false
  • English
  • Français

Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors*

Published online by Cambridge University Press:  09 March 2007

Takashi Sakata
Takashi Sakata
Affiliation:
Yakult Central Institute for Microbiological Research, Physiology Group, Kunitachi 186, Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Effects of short-chain fatty acids (SCFA) on epithelial proliferation of the intestine were studied in ileally fistulated rats fed on an elemental diet.

2. The stimulatory effect of daily doses of acetic, propionic and n-butyric acids (100,20 and 60 mM respectively; pH 6.1) per fistula (3 ml, twice daily) on crypt cell production rate (CCPR) appeared within 2 d and lasted for at least 5 d.

3. The daily doses of SCFA for 14 d increased daily CCPR three to four fold. This effect was independent of the presence of gut bacteria.

4. Effects of SCFA were dose-dependent and varied among acids (butyrate > propionate > acetate). The effect was independent of low lumen pH.

5. In contrast, SCFA inhibited epithelial proliferation of isolated rat caecal tissue in vitro.

6. These results suggest that SCFA are physiological lumen trophic factors mediated by a systemic mechanism in vivo.

7. It is concluded that SCFA are involved in the trophic effects of gut microbes, ingestion of fermentable fibre, and lumen contents.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 95 - 103
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Croft, D. N. & Cotton, B. (1973). Digestion 8, 144–160.CrossRefGoogle Scholar
Dexter, D. D., Lev, R., McKendall, G. R., Mitchell, P. & Calabres, P. (1984). Histochemical Journal 16, 137–149.CrossRefGoogle Scholar
Dobson, A. (1984). Quarterly Journal of Experimental Physiology 69, 599–606.Google Scholar
Galfi, P., Neogrady, S. & Kutas, F. (1986). Journal of Veterinary MedicineA 33, 47–52.Google Scholar
Galfi, P., Veresegyhazy, T., Neogrady, S. & Kutas, F. (1981). Zentralblatt für Veterinär Medizin 28A, 259–261.CrossRefGoogle Scholar
Ginsburg, E., Salamon, D., Sreevalsan, T. & Freese, E. (1973). Proceedings of the National Academy of Sciences USA 70, 2457–2461.Google Scholar
Goodlad, R. A., Al-mukhtar, M. Y. T., GhateriM. A, M. A,,Bloom, S. R. &Wright, N. A. ( 1983). Virchows Archiv (Cell Pathology) 43, 55–62.CrossRefGoogle Scholar
Goodlad, R. A. & Wright, N. A. (1983). British Journal of Nutrition 50, 91–98.Google Scholar
Horino, M. L., Machlin, J., Hertelendy, F. & Kipnis, D. M. (1968). Endocrinology 83, 118–128.CrossRefGoogle Scholar
Hoskins, L. C. (1978). In The Glycoconjugates vol.2, pp. 235–253 [Horowitz, M. I. and Pigman, W., editors]. London and New York: Academic Press.CrossRefGoogle Scholar
Jacobs, L. R. & Lupton, J. R. (1984). American Journal of Physiology 246, G378–G385.Google Scholar
Janne, P., Carpentier, Y. & Willems, G. (1977). Digestive Diseases 22, 808–812.Google Scholar
Keppel, G. (1973). Design and Analysis: A Researcher's Handbook pp. 137–138. Englewood Cliffs: Prentice-Hall.Google Scholar
Komai, M., Takehisa, F. & Kimura, S. (1982). Nutritional Reports International 26, 255–261.Google Scholar
Kruh, J. (1982). Molecular and Cellular Biochemistry 42, 65–82.Google Scholar
Kvietys, P. R. & Granger, D. N. (1981). American Journal of Physiology 193, 95G–113G.Google Scholar
Leek, B. F. & Harding, R. H. (1975). In Digestion and Metabolism in the Ruminant, pp. 60–76 [McDonald, I. W. and Warner, A. C. I., editors]. Armidale: University of New England Publishing Unit.Google Scholar
Levine, G., Deren, J. J., Steiger, E. & Zinno, R. (1974). Gastroenterology 67, 975–982.CrossRefGoogle Scholar
Lupton, J. R., Coder, D. M. & Jacobs, L. R. (1985). American Journal of Physiology 249, G382–G388.Google Scholar
Meslin, J. C., Sacquet, E. & Riottot, R. (1981). Reproduction, Nutrition et Developpment 21, 651–659.CrossRefGoogle Scholar
Riecken, E. D. & Menge, H. (1977). Acta Hepato-Gastroenterologia 24, 389–399.Google Scholar
Roediger, W. E. W. (1982). In Colon and Nutrition, pp. 11–24 [Kasper, H. and Goebell, H., editors]. Lancaster: MTP Press.Google Scholar
Ryan, G. P., Dudrick, S. J., Copeland, E. M. & Johnson, L. R. (1979). Gastroenterology 77, 658–663.Google Scholar
Sakata, T. (1984). Canadian Journal of Animal Science 64, Suppl.189–190.CrossRefGoogle Scholar
Sakata, T. (1986). Journal of Nutritional Sciences and Vitaminology 32, 355–362.CrossRefGoogle Scholar
Sakata, T., Hikosaka, K., Shiomura, Y. & Tamate, H. (1980). British Journal of Nutrition 44, 325–331.CrossRefGoogle Scholar
Sakata, T. & Tamate, H. (1978). Journal of Dairy Science 61, 1109–1113.Google Scholar
Sakata, T. & Tamate, H. (1979). Journal of Dairy Science 62, 49–52.Google Scholar
Sakata, T. & von Engelhardt, W. (1983). Comparative Biochemistry and Physiology 74A, 459–462.Google Scholar
Sakata, T. & Yajima, T. (1984). Quarterly Journal of Experimental Physiology 69, 639–648.CrossRefGoogle Scholar
Sokal, R. R. &Rohlf, F. J. (1981).Biometry, 2nd ed. San Francisco: Freeman.Google Scholar
Stragand, J. J. & Hagemann, R. N. (1977). American Journal of Physiology 233, E208–E211.Google Scholar
Tamate, H., McGilliard, A. D., Jacobson, N. L. & Getty, R. (1962). Journal of Dairy Science 45, 408–420.CrossRefGoogle Scholar
Topping, D. L. & Illman, R. J. (1986). Medical Journal of Australia 144, 307–309.CrossRefGoogle Scholar
Umesaki, Y., Yajima, T., Yokokura, T. & Mutai, M. (1979). Pflügers Archiv 379, 43–48.H.CrossRefGoogle Scholar
Weser, E., Vandeventer, A. & Tawil, T. (1982). Scandinavian Journal of Gastroenterology 74, Suppl.105–113.Google Scholar
Wimber, D. R. & Lamerton, L. F. (1973). Radiation Research 18, 137–146.CrossRefGoogle Scholar
Wright, N. A. & Appleton, D. R. (1980). Cell and Tissue Kinetics 13, 643–663.Google Scholar
Yajima, T. (1985). Journal of Physiology 368, 667–678.CrossRefGoogle Scholar
Yang, M. G., anoharan, K. & Mickelsen, O. (1970). Journal of Nutrition 100, 545–550.Google Scholar