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Tomatoes have natural anti-thrombotic effects

Published online by Cambridge University Press:  09 March 2007

J. Yamamoto ,
T. Taka ,
K. Yamada ,
Y. Ijiri ,
M. Murakami ,
Y. Hirata ,
A. Naemura ,
M. Hashimoto ,
T. Yamashita  and
K. Oiwa
...Show all authors
J. Yamamoto*
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
T. Taka
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
K. Yamada
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
Y. Ijiri
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
M. Murakami
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
Y. Hirata
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
A. Naemura
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
M. Hashimoto
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
T. Yamashita
Affiliation:
Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan
K. Oiwa
Affiliation:
Communications Research Laboratory, Kansai Advanced Research Centre, Kobe, Japan
J. Seki
Affiliation:
Biomedical Engineering, National Cardiovascular Centre, Osaka, Japan
H. Suganuma
Affiliation:
Research Institute, Kagome Co. Ltd., Tochigi, Japan
T. Inakuma
Affiliation:
Research Institute, Kagome Co. Ltd., Tochigi, Japan
T. Yoshida
Affiliation:
National Institute of Vegetable and Tea Science, National Agricultural Research Organization, Mie, Japan
*
*Corresponding Author: Dr J. Yamamoto, fax +81 78 974 5689, email yamamoto@nutr.kobegakuin.ac.jp
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Abstract

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The prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet may be an important risk factor for thrombotic events. The daily intake of an anti-thrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to test tomato extracts for anti-thrombotic effects and to identify those varieties that have such an effect. A shear-induced platelet-function test (haemostatometry) was used to test anti-thrombotic potential in vitro. Extracts from those tomato varieties that showed a significant anti-thrombotic activity in vitro were further assessed in vivo, using a laser-induced thrombosis test in mice. One tomato variety (KG99-4) showed significant anti-thrombotic activity both in vitro and in vivo. KG99-4 inhibited not only platelet-rich thrombus formation but also had a thrombolytic effect. It is concluded that haemostatometry can detect and classify the anti-thrombotic potential of fruits and vegetables and offers a simple way of screening for such effects.

Keywords

TomatoesPlatelet aggregationThrombosisCardiovascular disease
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 6 , December 2003 , pp. 1031 - 1038
Copyright
Copyright © The Nutrition Society 2003

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