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Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats

Published online by Cambridge University Press:  09 March 2007

J. B. T. ROCHA ,
C. F. Mello ,
J. J. F. Sarkis  and
R. D. Dias
J. B. T. ROCHA
Affiliation:
Departamento de Bioquimica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre 90050, RS, Brazil
C. F. Mello
Affiliation:
Departamento de Bioquimica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre 90050, RS, Brazil
J. J. F. Sarkis
Affiliation:
Departamento de Bioquimica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre 90050, RS, Brazil
R. D. Dias
Affiliation:
Departamento de Bioquimica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre 90050, RS, Brazil
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Abstract

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The presence of activities that hydrolyse externally added ATP to adenosine in synaptosomal preparations from various sources is well demonstrated. The hydrolysis of ATP to AMP can be mediated either by the concerted action of enzymes or by an ATP-diphosphohydrolase (EC 3.6.1.5; apyrase). Undernutrition during the preweaning period can delay the development of several enzymes involved in the metabolism of neurotransmitters or neuronal function. In young rats, the presence of an apyrase in synaptosomal preparations from cerebral cortex was investigated. The results suggested that the hydrolysis of externally added ATP and ADP can be mediated by a single enzyme. The effects of preweaning undernutrition on the hydrolysis of ATP and ADP were also investigated. In weanling rats, previous undernutrition caused a decrease of about 20% in the hydrolysis of both substrates in synaptosomal fractions.

Keywords

ATP-diphosphohydrolasePreweaning undernutritionSynaptosomal ATPase and ADPaseRat
Type
Maternal Nutrition and Metabolism of Offspring
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 273 - 283
Copyright
Copyright © The Nutrition Society 1990

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