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Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

Published online by Cambridge University Press:  09 March 2007

Elizabeth J. Brink ,
Emerentia C. H. van Beresteijn ,
Pieter R. Dekker  and
Anton C. Beynen
Elizabeth J. Brink
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Emerentia C. H. van Beresteijn
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Pieter R. Dekker
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands and Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands
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Abstract

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The effect of lactose on the urinary excretion of Mg and Ca, as an index of absorption, was studied in a double-blind, crossover study during three 1-week periods. Twenty-four healthy, lactose-tolerant, adult volunteers maintained their habitual diets with the exception that all lactose-containing dairy products in the diet were replaced by 600 g/d of three specially prepared dairy products. These products were based on either lactose-enriched cow's milk or lactose-enriched, lactase (EC 3.2.1.23)-treated cow's milk, with or without added Mg, and were given in turn during 1 week. Lactose intake was increased by 127 mmol/d (46 g/d) while taking the lactose-enriched products. While taking the Mg-enriched products, Mg intake was increased by 2.8 mmol/d (69 mg/d) which was equivalent to 17% of the habitual Mg intake. Apart from the lactose and Mg intake, nutrient intake was comparable during the three dietary periods. Urinary excretions of Mg and Ca were used as indicators for their absorption. Mg supplementation significantly increased urinary Mg excretion by 0.97 mmol/d (equivalent to an increase of 18%, P < 0.001), indicating that urinary Mg excretion is a valid indicator for intestinal Mg absorption. Hydrolysis of lactose did not affect urinary excretion of Mg and Ca, which implies that lactose intake does not affect the absorption of Mg and Ca in healthy adults.

Keywords

LactoseMagnesiumCalciumHumans
Type
Mineral Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 3 , May 1993 , pp. 863 - 870
Copyright
Copyright © The Nutrition Society 1993

References

Adams, N. D., Gray, R. W. & Lemann, J. (1979). The efects of oral CaCO3, loading and dietary deprivation on plasma 1,25-dihydroxy-vitamin D concentrations in healthy adults. Journal of Clinical Endocrinology and Metabolism 48, 1008–1016.CrossRefGoogle Scholar
Andrieux, C. & Sacquet, E. (1983). Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat. Reproduction Nutrition Développement 23, 258–271.CrossRefGoogle ScholarPubMed
Armbrecht, H. & Wasserman, R. (1979). Enhancement of Ca2+ uptake by lactose in the rat small intestine. Journal of Nutrition 106, 1265–1271.CrossRefGoogle Scholar
Behling, A. R. & Greger, J. L. (1990). Importance of lactose in yoghurt for mineral utilization. Journal of Agricultural and Food Chemistry 38, 200–204.CrossRefGoogle Scholar
Berner, L. A., McBean, L. D. & Lofgren, P. A. (1990). Calcium and chronic disease prevention: challenges to the food industry. Food Technology 44, 50–70.Google Scholar
Birlouez-Aragon, I. (1988). Effect of lactose on calcium absorption during duodenal milk perfusion. Reproduction Nutrition Développement 28, 1465–1472.CrossRefGoogle ScholarPubMed
Brink, E. J., Dekker, P. R., van Beresteijn, E. C. H. & Beynen, A. C. (1991). Inhibitory effect of dietary soybean protein vs casein on magnesium absorption in rats. Journal of Nutrition 121, 1373–1381.CrossRefGoogle ScholarPubMed
Brink, E. J., Dekker, P. R., van Beresteijn, E. C. H. & Beynen, A. C. (1992). Bioavailability of magnesium and calcium from cow's milk and soya-bean beverage in rats. British Journal of Nutrition, 68, 271–282.CrossRefGoogle ScholarPubMed
Brons, C. & Olieman, C. (1983). Study of high-performance liquid chromatographic separation of reducing sugars applied to the determination of lactose in milk. Journal of Chromatography 259, 79–86.CrossRefGoogle Scholar
Cochet, B., Jung, A., Griessen, M., Bartholdi, P., Schaller, P. & Donath, A. (1983). Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects. Gastroenterology 84, 935–940.CrossRefGoogle ScholarPubMed
Condon, J., Nassim, J. R., Hilbe, A., Millard, F. J. H. & Stainhope, E. M. (1970). Calcium and phosphorus metabolism in relation to lactose tolerance. Lancet 16, 1027–1029.CrossRefGoogle Scholar
Debognie, J. C., Newcomer, A. D., McGill, D. B. & Phillips, S. F. (1979). Absorption of nutrients in lactase deficiency. Digestive Diseases and Sciences 24, 225–231.CrossRefGoogle Scholar
De Groot, A. P. & Hoogendoorn, P. (1957). The detrimental effect of lactose. II. Quantitative lactase determinations in various mammals. Netherlands Milk and Dairy Journal 11, 290–303.Google Scholar
Fiske, C. H. & Subbarow, Y. (1924). The colorimetric determination of phosphorus. Journal of Biological Chemistry 66, 375–400.CrossRefGoogle Scholar
Fournier, P. (1954). L'effet protecteur du lactose vis-á-vis du squelette de la ratte allaitante (Protecting effect of lactose on the skeletal growth of the weanling rat). Academic Sciences 238, 509–511.Google Scholar
Fournier, P. & Dupuis, Y. (1960). Pouvoir antirachitique de composés divers dits de structure lactose, glucosamine, L-xylose, mannitol (Anti-rickets effects of lactose, glucosamine, L-xylose and mannitol). Academic Sciences 250, 3050–3052.Google Scholar
Fournier, P., Dupuis, Y. & Fournier, Y. (1971). Effect of lactose on the absorption of alkaline earth metals and intestinal lactase activity. Israel Journal of Medical Sciences 7, 103–107.Google ScholarPubMed
Goren, M. P., Osborne, S. & Wright, R. K. (1986). A peroxidase coupled kinetic enzymatic procedure evaluated for measuring serum and urinary creatinine. Clinical Chemistry 32, 548–551.CrossRefGoogle ScholarPubMed
Greger, J. L., Gutkowski, C. M. & Khazen, R. R. (1989). Interactions of lactose with calcium, magnesium and zinc in rats. Journal of Nutrition 119, 1691–1697.CrossRefGoogle ScholarPubMed
Greger, J. L., Krzykowski, C. E., Khazen, R. R. & Krashoc, C. (1987). Mineral utilization by rats fed commercially available calcium supplements or milk. Journal of Nutrition 117, 717–724.CrossRefGoogle ScholarPubMed
Hardwick, L. L., Jones, M. R., Brautbar, N. & Lee, D. B. N. (1991). Magnesium absorption: mechanisms and the influence of vitamin D, calcium and phosphate. Journal of Nutrition 121, 13–23.CrossRefGoogle ScholarPubMed
Heaney, R. P., Weaver, C. M. & Fitzsimmons, M. L. (1990). Influence of calcium load on absorption fraction. Journal of Bone and Mineral Research 11, 1135–1138.CrossRefGoogle Scholar
Hodgkinson, A. & Heaton, F. W. (1965). The effect of food ingestion on the urinary excretion of calcium and magnesium. Clinica Chimica Acta 11, 354–362.CrossRefGoogle ScholarPubMed
International Dairy Federation (1986). Determination of nitrogen content (Kjeldahl method) and calculation of crude protein content. International IDF standard 20A. Brussels: International Dairy Federation.Google Scholar
Kobayashi, A., Kawai, S., Ohbe, Y. & Nagashima, Y. (1975). Effects of dietary lactose and a lactase preparation on the intestinal absorption of calcium and magnesium in normal infants. American Journal of Clinical Nutrition 28, 681–683.CrossRefGoogle Scholar
Kocian, J., Skala, I. & Bakos, K. (1973). Calcium absorption from milk and lactose-free milk in healthy subjects and patients with lactose intolerance. Digestion 9, 317–324.CrossRefGoogle ScholarPubMed
Morris, E. R., Ellis, R., Steele, P. & Moser, P. B. (1988). Mineral balance of adult men consuming whole or dephytinized bran. Nutrition Research 8, 445–458.CrossRefGoogle Scholar
Nordin, B. E. C. (1976). Calcium, Phosphate and Magnesium Metabolism. New York: Churchill Livingstone.Google Scholar
Pansu, D. & Chapuy, M. (1970). Calcium absorption enhancement by lactose and xylose. Catcified Tissue Research 4, 155–156.CrossRefGoogle Scholar
Pansu, D., Chapuy, M. C., Milani, M. & Bellaton, C. (1975). Transepithelial calcium transport enhanced by xylose and glucose in the rat ligated loop. In Proceedings of the XIth European Symposium on Calcified Tissue, pp. 45–51 [Mielsen, P. and Hjoring-Hanson, E., editors]. Copenhagen: Fald's.Google Scholar
Recker, R. R., Bammi, A., Barger-Lux, M. J. & Heaney, R. P. (1988). Calcium absorbability from milk products, an imitation milk and calcium carbonate. American Journal of Clinical Nutrition 47, 93–95.CrossRefGoogle ScholarPubMed
Schaafsma, G., Dekker, P. R. & De Waard, H. (1988). Nutritional aspects of yogurt. 2. Bioavailability of essential minerals and trace elements. Netherlands Milk and Dairy Journal 42, 135–146.Google Scholar
Schwartz, R., Walker, G., Linz, M. D. & MacKellar, I. (1973). Metabolic responses of adolescent boys to two levels of dietary magnesium and protein. I. Magnesium and nitrogen retention. American Journal of Clinical Nutrition 26, 510–518.CrossRefGoogle ScholarPubMed
Sheikh, M. S., Santa Ana, C. A., Nicar, M. J., Schiller, L. R. & Fordtran, J. S. (1987). Gastrointestinal absorption of calcium salts. New England Journal of Medicine 317, 532–536.CrossRefGoogle ScholarPubMed
Shiga, A., Sasaki, T. & Horii, N. (1987). Correlations among pH and Mg, Ca, P, Na, K, C1− and HCO3− contents of digesta in the gastrointestinal tract. Japanese Journal of Veterinary Sciences 49, 973–979.Google Scholar
Shills, M. F. (1984). Magnesium. In Nutrition Reviews. Present Knowledge in Nutrition, 5th ed., pp. 422–438 [Olsen, R. E., Broquist, H. P., Chichester, C. O., Darby, W. J., Kolbye, A. C. and Stalvey, R. M., editors]. Washington, DC: Nutrition Foundation.Google Scholar
Shills, M. F. (1988). Magnesium in health and disease. Annual Reviews of Nutrition 8, 429–460.CrossRefGoogle Scholar
Spayd, R. W., Bruschi, B., Burdick, B. A., Dappen, G. M., Fikenberry, J. N., Esders, T. W., Figueras, J., Goodhye, C. T., La Rossa, D. D., Nelson, R. W., Rand, R. N. & Wu, T. W. (1978). Multilayer film elements for clinical chemistry. Clinical Chemistry 24, 1343–1344.CrossRefGoogle Scholar
Spencer, H., Kramer, L. & Osis, D. (1984). Effect of calcium on phosphorus metabolism in man. American Journal of Clinical Nutrition 40, 219–225.CrossRefGoogle ScholarPubMed
Stichting NEVO (1989). Nederlandse voedingsstoffen bestand, NEVO-Tabel 1989/1990. s-Gravenhage. The Netherlands: Voorlichtingsbureau voor de Voecding.Google Scholar
van Beresteijn, E. C. H., Brussaard, J. H. & van Schaik, M. (1990). Relationship between the calcium-to-protein ratio in milk and the urinary calcium excretion in healthy adults – a controlled crossover study. American Journal of Clinical Nutrition 52, 142–146.CrossRefGoogle ScholarPubMed
Vaughan, O. & Filler, J. (1960). The enhancing action of certain carbohydrates on the intestinal absorption of calcium in rats. Journal of Nutrition 71, 10–14.CrossRefGoogle Scholar
Wirth, F. H. Jr, Numerof, B., Pleban, P. & Neylan, M. J. (1990). Effect of lactose on mineral absorption in preterm infants. Journal of Pediatrics 117, 283–287.CrossRefGoogle ScholarPubMed
Ziegler, E. E. & Fomon, S. J. (1983). Lactose enhances mineral absorption in infancy. Journal of Pediatrics 2, 288–294.Google ScholarPubMed