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Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK

Published online by Cambridge University Press:  09 March 2007

Liya Yan ,
B. Zhou ,
David Greenberg ,
Laura Wang ,
Shailja Nigdikar ,
Celia Prynne  and
Ann Prentice
Liya Yan*
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
B. Zhou
Affiliation:
Department of Preventive Medicine, Shenyang Medical College, 146 Huanghe North Street, Shenyang, 110034, PR China
David Greenberg
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK NHSU Learning Needs Observatory, Victoria House, Capital Park, Fulbourn, Cambridge, CB1 5XB, UK
Laura Wang
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
Shailja Nigdikar
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
Celia Prynne
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
Ann Prentice
Affiliation:
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
*
*Corresponding author: Dr Liya Yan, fax +44 1223 437515, email, liya.yan@mrc-hnr.cam.ac.uk
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Abstract

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To explore whether differences in vitamin K nutrition might, at least in part, underlie differences in fracture incidence between Asian and European populations, the vitamin K status of older individuals in Shenyang, China (eighty-six men, ninety-two women) and in Cambridge, UK (sixty-seven men, sixty-seven women) was compared. Dietary information was collected by food questionnaire in Shenyang and food diary in Cambridge and used to estimate the intake and sources of phylloquinone. Fasting blood was analysed for phylloquinone, triacylglycerol, total osteocalcin (tOC) and undercarboxylated osteocalcin (expressed as percentage of tOC; %ucOC). The mean intakes of green leafy vegetables were 127 (SD 90) g/d in Shenyang and 39 (SD 48) g/d in Cambridge. The estimated phylloquinone intakes (geometric means) were 247 (95% CI 226, 270) μg/d in Shenyang and 103 (95% CI 94, 112) μg/d in Cambridge. Plasma phylloquinone concentrations (geometric means) were significantly higher in the Shenyang subjects (2·17 (95% CI 1·95, 2·42) nmol/l) than in the Cambridge subjects (0·69 (95% CI 0·63, 0·76) nmol/l; P<0·001). Plasma phylloquinone concentration was positively related to phylloquinone intake in both the Shenyang (coefficient 0·17 (SE 0·08); P=0·03) and Cambridge subjects (coefficient 0·29 (SE 0·10); P=0·005). tOC concentration and %ucOC (after adjusting for tOC) were significantly lower in the Shenyang than in the Cambridge subjects (tOC 25·2 (SE 4·2) % and %ucOC 68·5 (SE 10·0) % lower respectively; P<0·001). After adjusting for tOC and triacylglycerol, %ucOC was negatively related to plasma phylloquinone concentration in both the Shenyang (coefficient −0·41 (SE 0·11); P=0·0003) and Cambridge subjects (coefficient −0·17 (SE 0·07); P=0·02). The present study demonstrates that older individuals in northern China have a better vitamin K status compared with their British counterparts in Cambridge, UK.

Keywords

PhylloquinoneUndercarboxylated osteocalcinChinaUK
Type
Review Article
Information
British Journal of Nutrition , Volume 92 , Issue 6 , December 2004 , pp. 939 - 945
Copyright
Copyright © The Nutrition Society 2004

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