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Acute allergic reaction due to the administration of fibrinolytic therapy for ST-segment elevation myocardial infarction: case report and discussion

Published online by Cambridge University Press:  21 May 2015

Geoff C. Mills ,
Robert T. Arntfield  and
Robert J. Sedran
Geoff C. Mills
Affiliation:
University of Western Ontario CCFP-EM Residency Program, London, Ont.
Robert T. Arntfield
Affiliation:
Medical Student, University of Western Ontario, London, Ont.
Robert J. Sedran*
Affiliation:
Department of Emergency Medicine, London Health Sciences Centre, and Division of Emergency Medicine, Department of Medicine, University of Western Ontario, London, Ont.
*
Department of Emergency Medicine, London Health Sciences Centre, 375 South St., London ON N6A 4G5; rsedran@uwo.ca

Abstract

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Although a rare phenomenon, acute allergic reactions to fibrinolytic and heparin therapy have been described in the literature. We report the case of a 63-year-old woman who experienced a severe anaphylactic reaction while undergoing fibrinolytic therapy with tissue plasminogen activator for an ST-segment elevation myocardial infarction. Overall outcome was successful, but patient morbidity was increased because of the reaction and the subsequent therapy administered.

Keywords

fibrinolytic therapyallergicanaphylaxistPAheparin
Type
Case Report • Observations de cas
Information
Canadian Journal of Emergency Medicine , Volume 5 , Issue 6 , November 2003 , pp. 421 - 423
Copyright
Copyright © Canadian Association of Emergency Physicians 2003

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