Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-14T09:34:09.780Z Has data issue: false hasContentIssue false

Oral rivaroxaban for the treatment of symptomatic pulmonary embolism: are we ready?

Published online by Cambridge University Press:  04 March 2015

Martin Kuuskne*
Affiliation:
Department of Emergency Medicine, Royal Victoria Hospital
Jerrald Dankoff
Affiliation:
Department of Emergency Medicine, Jewish General Hospital, Montreal, QC
*
Department of Emergency Medicine, Royal Victoria Hospital, 687 Pine Avenue West, A4.62, Montreal, QC H3A 1A1; martin.kuuskne@mail.mcgill.ca

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Knowledge To Practice • Des connaissances à la pratique
Copyright
Copyright © Canadian Association of Emergency Physicians 2014

References

REFERENCES

1. Silverstein, MD, Heit, JA, Mohr, DN, et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998;158:585–93, doi:10.1001/archinte.158.6.585.Google Scholar
2. Douketis, JD, Kearon, C, Bates, S, et al. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. JAMA 1998;279:458–62, doi:10.1001/jama.279.6.458.Google Scholar
3. Bauersachs, R, Berkowitz, SD, Brenner, B, et al. Oral rivaroxaban for symptomatic venous thromboembolism. NEngl J Med 2010;363:2499–510, doi:10.1056/NEJMoa1007903.Google Scholar
4. Eriksson, BI, Dahl, OE, Rosencher, N, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007;5:2178–85, doi:10.1111/j.1538-7836.2007.02748.x.Google Scholar
5. Eriksson, BI, Dahl, OE, Rosencher, N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomized, double-blind, non-inferiority trial. Lancet 2007;370:949–56, doi:10.1016/S0140-6736(07)61445-7.Google Scholar
6. Schulman, S, Kearon, C, Kakkar, AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. NEngl J Med 2009;361:2342–52, doi:10.1056/NEJMoa0906598.CrossRefGoogle ScholarPubMed
7. Connolly, SJ, Ezekowitz, MD, Yusuf, S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139–51, doi:10.1056/NEJMoa0905561.CrossRefGoogle ScholarPubMed
8. Eerenberg, ES, Kamphuisen, PW, Sijpken, MK, et al. Reversal of rivaroxaban and dabgatran by prothrombin complex concentrate; a randomized, placebo-controlled, crossover study in healthy patients. Circulation 2011;124:1573–9, doi:10.1161/CIRCULATIONAHA.111.029017.Google Scholar
9. Lee, S, Anglade, M, Pisacane, R, et al. Cost-effectiveness of rivaroxaban compared to warfarin for stroke prophylaxis in atrial fibrillation. Am J Cardiol 2012;110:845–51.Google Scholar