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3H Leucine Incorporation Into Myofibrils of Normal and Dystrophic Mouse Skeletal Muscle

Published online by Cambridge University Press:  18 September 2015

G. Monckton  and
H. Marusyk
G. Monckton*
Affiliation:
Muttart-Collip Memorial E.M. Laboratory, Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta
H. Marusyk
Affiliation:
Muttart-Collip Memorial E.M. Laboratory, Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta
*
Room 9, 103B, 11282 - 84th Ave., Edmonton, Alberta, Canada T6G 2G3
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The study of 3H leucine incorporation into skeletal muscle of mouse muscular dystrophy (129 ReJ/dy Bar Harbour strain) shows the uptake of isotope into myofibrils. The techniques employed were light and EM autoradiography before and after glycerination (Szent-Gyorgyi 1947). The results indicate a marked drop in uptake of the 3H-Leucine into myofibrils in the dystrophic animals, supporting the contention of Nihei et al (1971) that reduced myosin synthesis occurs in mouse muscular dystrophy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 1 , February 1975 , pp. 1 - 4
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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