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Adenosine and Migraine

Published online by Cambridge University Press:  18 September 2015

R. Guieu ,
C. Devaux ,
H. Henry ,
G. Bechis ,
J. Pouget ,
D. Mallet ,
F. Sampieri ,
M. Juin ,
R. Gola  and
H. Rochat
R. Guieu*
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
C. Devaux
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
H. Henry
Affiliation:
Service de Neurologie CHU Bordeaux, Hopital Pellegrin, Bordeaux
G. Bechis
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
J. Pouget
Affiliation:
Service des maladies Neuro-Musculaire, CHU Timone, Marseille
D. Mallet
Affiliation:
Laboratoire d'Hématologie, Hôpital Nord, Marseille
F. Sampieri
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
M. Juin
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
R. Gola
Affiliation:
Service de Stomatologie et Chirurgie Maxillo Faciale, Hôpital Nord, Marseille, France
H. Rochat
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
*
UMR CNRS 6560, Faculté de Médecine Secteur, Nord, Bd P Dramard 13020, Marseille, France.
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Abstract:

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Background:

Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.

Methods:

We have investigated circulating adenosine levels in 12 patients suffering from migraine without aura, during crises and in crisis-free periods, and have compared the levels noted to those of a population of 10 controls. To determine if there are interactions between adenosine and serotonin, we examined the effect of adenosine and antagonists on the uptake and the release of (14C) serotonin by platelets.

Results and conclusions:

We have reached a dual conclusion: 1) during migraine headaches there is an increase (mean 68%) in circulating adenosine levels and this increase may participate in cephalalgia; 2) activation of A2 receptors by adenosine causes a dose-dependent inhibition of calcium-dependent serotonin uptake by platelets. This inhibition of uptake could participate in the rapid elimination of serotonin in migraine sufferers. As a result of this, the use of adenosine antagonists could be an effective complementary treatment for migraine.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 25 , Issue 1 , February 1998 , pp. 55 - 58
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

References

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