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β-Amyloid Protein in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Josephine Nalbantoglu
Josephine Nalbantoglu*
Affiliation:
Departments of Medicine, Neurology & Neurosurgery, McGill Center for Studies in Agin, McGill University, Montreal
*
Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
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Abstract:

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β-amyloid protein, a 42-43 amino acid polypeptide, accumulates abnormally in senile plaques and the cerebral vasculature in Alzheimer's disease. This polypeptide is derived from a membrane-associated precursor which has several isoforms expressed in many tissues. The precursor protein is processed constitutively within the P-amyloid domain, leading to the release of the large β-terminal portion into the extracellular medium, β-amyloid protein may be toxic to certain neuronal cell types and its early deposition may be an important event in the pathogenesis of Alzheimer's disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 424 - 427
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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