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An Unusual Subacute Progressive Motor Neuronopathy with Myasthenia-like Features

Published online by Cambridge University Press:  18 September 2015

J.H. Noseworthy ,
A.D. Rae-Grant  and
W.F. Brown
J.H. Noseworthy*
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, London
A.D. Rae-Grant
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, London
W.F. Brown
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, London
*
Department of Clinical Neurological Sciences, University Hospital, 339 Windermere Road, P.O. Box 5339, London, Ontario, Canada N6A 5A5
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Abstract:

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The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of conjugate gaze paresis and the absence of many of the typical clinical and electromyographic (EMG) findings seen in this condition. The pathological findings were consistent with either a motor neuronopathy or an unusual variant of ALS. We review the clinical and pathological features of this unusual case in this report.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 3 , August 1988 , pp. 304 - 309
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

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