Hostname: page-component-745bb68f8f-l4dxg Total loading time: 0 Render date: 2025-01-24T23:13:50.633Z Has data issue: false hasContentIssue false
  • English
  • Français

Beta-Adrenoceptor Modulation in a Case of Pure Autonomic Failure

Published online by Cambridge University Press:  18 September 2015

Sergio Perna ,
Rocco Leone ,
Maria Jussie Farace ,
Vincenzo Brescia-Morra ,
Giuseppe Campanella  and
Gregorio Brevetti
Sergio Perna*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Rocco Leone*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Maria Jussie Farace*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Vincenzo Brescia-Morra*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Giuseppe Campanella*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
Gregorio Brevetti*
Affiliation:
Department of Medicine and Neurological Clinic, 2nd Medical School, University of Naples, Naples, Italy
*
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Via Principati 17, 84100 Salerno, Italy
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In a patient with pure autonomic failure, exercise did not modify beta-adrenoceptor density, probably due to an insufficient increase in plasma catecholamines. Isoproterenol infusion increased the number of beta-adrenoceptor by only 17%. Since in control subjects an increased beta-adrenoceptor level was found, following both physical stress and isoproterenol infusion, we suggest that the lack of increased beta-adrenoceptor levels may contribute to the poor circulatory adjustments observed in autonomic dysfunction during activities involving the sympathetic nervous system.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 1 , February 1992 , pp. 80 - 83
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

References

1. Bannister, R.Introduction and classification. In: Bannister R, ed. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford: University Press, 1988: 1–20.Google Scholar
2. Mathews, MR.Assessing the peripheral ganglia in autonomic failure. In: Bannister, R, ed. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford: University Press, 1988: 521–543.Google Scholar
3. Polinsky, RJ.Neurotransmitter and neuropeptide function in autonomic failure. In: Bannister, R, ed. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford: University Press, 1988: 321–347.Google Scholar
4. Ziegler, MG, Lake, CR, Kopin, IJ.The sympathetic-nervous-system defect in primary orthostatic hypotension. N Engl J Med 1977; 296: 293–297.CrossRefGoogle ScholarPubMed
5. Brevetti, G, Bonaduce, D, Rossi, F, et al. Orthostatic hypotension: mechanisms and hemodynamics. Acta Neurol 1987; 42: 377–389.Google Scholar
6. Robertson, D, Hollister, AS, Carey, EL, et al. Increased vascular beta-adrenoceptor response in autonomic dysfunction. J Am Coll Cardiol 1984; 3: 850–856.CrossRefGoogle ScholarPubMed
7. Fraser, J, Nadeau, J, Robertson, D, et al. Regulation of human leucocyte beta-receptors by endogenous catecholamines. Relationship of leucocyte beta-receptor density to the cardiac sensitivity to isoproterenol. J Clin Invest 1981; 67: 1777–1784.CrossRefGoogle Scholar
8. Huy, KKP, Connolly, ME.Increased numbers of beta receptors in orthostatic hypotension due to autonomic dysfunction. N Engl J Med 1981; 304: 1473–1476.Google Scholar
9. Davies, IB, Sudera, D, Saguella, G.Increased numbers of alpha-receptors in sympathetic denervation supersensitivity in man. J Clin Invest 1982; 69: 775–784.CrossRefGoogle ScholarPubMed
10. Ibrahim, MM.Localization of lesion in patients with idiopathic orthostatic hypotension Br Heart J 1975; 37: 868–872.CrossRefGoogle ScholarPubMed
11. Boyum, A.Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21 (Suppl 97): 77–79.Google ScholarPubMed
12. Brevetti, G, Leone, R, Caracciolo, G, et al. Incremento della popolazione beta-adrenocettoriale linfocitaria in corso di esercizio fisico. Giorn It Cardiol 1990; 20: 20–23.Google Scholar
13. Hjemedalh, P.Catecholamine measurement in plasma by liquid chromatography with electrochemical detection. Methods Enzymol 1987; 42: 521–534.Google Scholar
14. Brevetti, G, Chiariello, M, Lavecchia, G, et al. Effects of propranolol in a case of orthostatic hypotension. Br Heart J 1979; 41: 245–248.CrossRefGoogle Scholar
15. Brevetti, G, Chiariello, M, Giudice, P, et al. Effective treatment of orthostatic hypotension by propranolol in the Shy-Drager syndrome. Am Heart J 1981; 102: 938–941.Google ScholarPubMed
16. Chiariello, M, Brevetti, G, Bonaduce, D, et al. Orthostatic hypotension due to autonomic dysfunction – different therapeutic effects of propranolol. Int J Cardiol 1983; 4: 455–462.CrossRefGoogle ScholarPubMed
17. Brevetti, G, Chiariello, M, Bonaduce, D, et al. 24-hour blood pressure recording in patients with orthostatic hypotension. Clin Cardiol 1985; 8: 406–412.CrossRefGoogle ScholarPubMed
18. Tohmeh, JF, Cryer, PE.Biphasic adrenergic modulation of beta adrenoceptors in man. Agonist-induced early increment and late decrement in beta adrenoceptor number. J Clin Invest 1980; 65: 836–840.CrossRefGoogle Scholar
19. Kronenberg, MW, Forman, MB, Onrot, J, et al. Enhanced left ventricular contractility in autonomic failure: assessment using pressure-volume relations. J Am Coll Cardiol 1990; 15: 1334–1442.CrossRefGoogle ScholarPubMed