Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-10T07:14:23.114Z Has data issue: false hasContentIssue false
  • English
  • Français

Bilateral Encephaloclastic Lesions In A 26 Week Gestation Fetus: Effect On Neuroblast Migration

Published online by Cambridge University Press:  18 September 2015

Margaret G. Norman
Margaret G. Norman*
Affiliation:
Division of Pathology, Eleanor M. Paterson, Department of Laboratory Medicine, Children's Hospital of Eastern Ontario and Department of Pathology, University of Ottawa, Ottawa, Ontario
*
Children's Hospital, 250 West 59th Avenue, Vancouver, B.C., V5X 1X2
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A 26 week gestation fetus with bilaterally symmetrical encephaloclastic lesions in the cerebral hemispheres is described. Information about gestation allows dating of the cerebral insult to the 3-4th fetal month. The history and morphology in this case suggest that insults occurring at or before the 3-4th fetal month interfere with normal neuroblast migration, producing a cerebral scar containing a band of neuroblasts arranged without order or lamination.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 3 , August 1980 , pp. 191 - 194
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Choi, B.E., Lapham, L.W. (1978). Radial glia in human fetal cerebrum: A combined Golgi, immunofluorescent and electron microscopie study. Brain Research 148: 295–311.CrossRefGoogle Scholar
Dvorák, I., Feit, J., Juránková, Z. (1978). Experimentally induced focal microgyria and status verrucosus deformis in rats — pathogenesis and interrelation. Histological and autoradiographical study. Acta Neuropathol. (Beri), 44: 121–129.CrossRefGoogle ScholarPubMed
Ikuta, F., Ohamo, E., Yamazaki, K.Takeda, S.Egawa, S., Ichikawa, T. (1979). Morphology of migrating glial cells in normal development, neoplasia and other disorders. Progress in Neuropathology 4, 377404Google Scholar
Levine, D.N., Fisher, M.A., Caviness, V.S.JR. (1974). Porencephaly with microgyria: a pathologic study. Acta Neuropathol. (Beri), 29:99–113.CrossRefGoogle ScholarPubMed
Richman, D.P., Stewart, R M..Caviness, V.S.JR. (1974). Cerebral microgyria in a 27 week fetus: an architectonic and topographic analysis. J. Neuropath, and Exp. Neurol. 33: 374–384.CrossRefGoogle Scholar
Sidman, R.L., Rakic, P. (1973). Neuronal migration, with special reference to the developing human brain: a review. Brain research 62: 1–35.CrossRefGoogle Scholar
Usher, R. and McLean, F. (1969). Intrauterine growth of live-born Caucasian infants at sea-level: Standards obtained from measurements in 7 dimensions. J. Pediatrics 74: 901–910.CrossRefGoogle ScholarPubMed
Williams, R.S., Ferrante, R.J., Caviness, V.S.JR. (1976). The cellular pathology of microgyria: A Golgi analysis. Acta Neuropathol. (Beri), 36: 269–283.CrossRefGoogle ScholarPubMed
Yakovlev, P.I. and Wadsworth, R.C. (1946). Schizencephalies. A study of the congenital clefts in the cerebral mantle. Clefts with fused lips. J. Neuropath, and Exp. Neurol. 5: 116–130.CrossRefGoogle ScholarPubMed