Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-13T01:54:58.515Z Has data issue: false hasContentIssue false
  • English
  • Français

Bilateral Temporal Lobe MRI Changes in Uncomplicated Hypoglycemic Coma

Published online by Cambridge University Press:  18 September 2015

B.F. Boeve ,
D.G. Bell  and
J.H. Noseworthy
B.F. Boeve
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
D.G. Bell
Affiliation:
Department of Radiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
J.H. Noseworthy*
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
*
Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 USA
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We report bilateral temporal lobe MRI findings in a patient following an episode of prolonged hypoglycemia uncomplicated by coexisting anoxia, hypotension, acidosis, drug intoxication, infection, or status epilepticus. The MRI findings are discussed in relation to the experimental and human data on hypoglycemic neuronal injury.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 22 , Issue 1 , February 1995 , pp. 56 - 58
Copyright
Copyright © Canadian Neurological Sciences Federation 1995

References

1. Chalmers, J, Risk, MTA, Kean, DM, et al. Severe amnesia after hypoglycemia: clinical, psychometric, and magnetic resonance imaging correlations. Diabetes Care 1991; 14: 922–925.CrossRefGoogle ScholarPubMed
2. Auer, RN, Siesjo, BK.Biological differences between ischemia, hypoglycemia, and epilepsy. Ann Neurol 1988; 24: 699–707.CrossRefGoogle ScholarPubMed
3. Auer, RN, Wieloch, T, Olsson, Y, Siesjo, BK.The distribution of hypoglycemic brain damage. Acta Neuropathol 1984; 64: 177–191.CrossRefGoogle ScholarPubMed
4. Auer, RN, Hugh, J, Cosgrove, E, Curry, B.Neuropathologic findings in three cases of profound hypoglycemia. Clin Neuropathol 1989; 8:63–68.Google ScholarPubMed
5. Auer, R, Kalimo, H, Olsson, Y, Wieloch, T.The dentate gyrus in hypoglycemia: pathology implicating excitotoxin-mediated neuronal necrosis. Acta Neuropathol 1985; 67: 279–288.CrossRefGoogle ScholarPubMed
6. Olney, JW.Glutamate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesions. J Neuropathol Exp Neurol 1969; 28: 455–474.CrossRefGoogle Scholar
7. Myers, RE.Lactic acid accumulation as a cause of brain edema and cerebral necrosis resulting from oxygen deprivation. In: Korobkin, R, Guillemineault, G, eds. Advances in Perinatal Neurology. New York: Spectrum Publishers, 1979: 85–114.Google Scholar
8. Tasker, RC, Coyle, JT, Vornov, JJ.The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801. J Neurosci 1992; 12: 4298–4308.CrossRefGoogle ScholarPubMed
9. Tombaugh, GC, Yang, SH, Swanson, RA, Sapolsky, RM.Glucocorticoids exacerbate hypoxic and hypoglycemic hippocampal injury in vitro: biochemical correlates and a role for astrocytes. J Neurochem 1992; 59: 137–146.CrossRefGoogle Scholar
10. Tromba, C, Salvaggio, A, Racagni, G, Volterra, A.Hypoglycemia-activated K channels in hippocampal neurons. Neurosci Lett 1992; 143: 185–189.CrossRefGoogle ScholarPubMed
11. LaManna, JC, Harik, SI.Regional comparisons of brain glucose influx. Brain Res 1985; 326: 299–305.CrossRefGoogle ScholarPubMed
12. Ng, T, Graham, DI, Adams, JH, Ford, I.Changes in the hippocampus and the cerebellum resulting from hypoxic insults: frequency and distribution. Acta Neuropathol 1989; 78: 438–443.CrossRefGoogle ScholarPubMed
13. Lee, BI, Lee, BC, Hwang, YM, et al. Prolonged ictal amnesia with transient focal abnormalities on magnetic resonance imaging. Epilepsia 1992; 33: 1042–1046.CrossRefGoogle ScholarPubMed
14. Kodama, T, Numaguchi, Y, Gellad, FE, et al. Magnetic resonance imaging of limbic encephalitis. Neuroradiology 1991; 33: 520–523.CrossRefGoogle ScholarPubMed
15. Lacomis, D, Khoshbin, S, Schick, RM.MR imaging of paraneoplastic limbic encephalitis. J Comput Assist Tomogr 1990; 14: 115–117.CrossRefGoogle ScholarPubMed